#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35240-1	uniprotkb:O14964-1	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-21239519	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22184874|imex:IM-27465-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	uniprotkb:O14964-1(isoform-parent)	-	-	-	figure legend:Fig 2a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2019/11/06	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rigid:VmcGwlJCjBMmqhw9BwrzFlKylvs	false	sufficient binding region:256-595	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99613	uniprotkb:P35240-1	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	intact:EBI-1014500|ensembl:ENSP00000344666	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22185149|imex:IM-27465-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	-	-	-	figure legend:Fig. 2b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2019/11/06	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rigid:IoCV/XBYQOnCPT4Dh+pUUr7hPo8	false	sufficient binding region:69-635	sufficient binding region:256-595	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-3	uniprotkb:Q99613	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22185153|imex:IM-27465-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	-	-	-	figure legend:Fig. 2b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/13	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	rigid:CBPcyV31fQTHpEvRCzg7kNOf3SU	false	mutation with no effect:41-41|mutation with no effect:197-197|mutation with no effect:219-219(449829)|mutation with no effect:220-220(643102)|mutation decreasing interaction strength:273-273|mutation increasing interaction strength:352-352(569661)|mutation increasing interaction strength:360-360(3282)|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:535-535(3286)|mutation increasing interaction strength:538-538(3287)|sufficient binding region:256-590|mutation disrupting interaction strength:46-46	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-1	uniprotkb:P35240-1	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-1014500|ensembl:ENSP00000344666	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22185197|imex:IM-27465-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	-	-	-	figure legend:FIG. 3, 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2019/11/06	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rigid:8D7xS7wrg6B9X67g8DahRc+YGZM	false	sufficient binding region:256-595	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-1	uniprotkb:Q01082	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25395845|imex:IM-27465-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	-	-	-	figure legend:Fig. 5|comment:Full length NF2 isoform does not binds with spectrin|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/13	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	rigid:osb1ROtWsH2VuDmdBZfdtJLZa6M	false	sufficient binding region:469-595	sufficient binding region:1716-1998	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-3	uniprotkb:O14964-2	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	intact:EBI-21581128	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396087|imex:IM-27465-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	uniprotkb:O14964-2(isoform-parent)	-	-	-	figure legend:Fig. 2a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/13	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606	rigid:BmoKze/UUZYxjKZJEOpabDPMKm8	false	mutation with no effect:41-41|mutation with no effect:197-197|mutation with no effect:219-219(449829)|mutation increasing interaction strength:220-220(643102)|mutation increasing interaction strength:273-273|mutation with no effect:352-352(569661)|mutation disrupting interaction strength:360-360(3282)|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:535-535(3286)|mutation disrupting interaction strength:538-538(3287)|sufficient binding region:256-590|mutation decreasing interaction strength:46-46	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964-1	uniprotkb:P35240-3	intact:EBI-21239519	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym)	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396138|imex:IM-27465-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O14964-1(isoform-parent)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	-	-	-	figure legend:Fig. 2a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/13	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rigid:wdS+tg+1y12QLB6cOEdi5Jidt3Q	false	-	mutation with no effect:41-41|mutation with no effect:197-197|mutation increasing interaction strength:219-219(449829)|mutation increasing interaction strength:220-220(643102)|mutation increasing interaction strength:273-273|mutation increasing interaction strength:352-352(569661)|mutation disrupting interaction strength:360-360(3282)|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:535-535(3286)|mutation disrupting interaction strength:538-538(3287)|sufficient binding region:256-590|mutation decreasing interaction strength:46-46	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-1	uniprotkb:P35240-3	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396714|imex:IM-27465-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	-	-	-	figure legend:Fig. 3, 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/14	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rigid:UE0X9hmMNRa22J2wmlH3gZUjLnU	false	-	mutation decreasing interaction strength:41-41|mutation increasing interaction strength:197-197|mutation with no effect:219-219(449829)|mutation with no effect:220-220(643102)|mutation with no effect:273-273|mutation decreasing interaction strength:352-352(569661)|mutation decreasing interaction strength:360-360(3282)|mutation decreasing interaction strength:364-364|mutation decreasing interaction strength:535-535(3286)|mutation decreasing interaction strength:538-538(3287)|sufficient binding region:256-590|mutation disrupting interaction strength:46-46	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-3	uniprotkb:P35240-3	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396759|imex:IM-27465-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	-	-	-	figure legend:Fig. 3, 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/14	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rigid:2odTDkyYbK+I8WehNt5Q/q0TinM	false	mutation decreasing interaction strength:41-41|mutation decreasing interaction strength:197-197|mutation decreasing interaction strength:219-219(449829)|mutation decreasing interaction strength:220-220(643102)|mutation decreasing interaction strength:273-273|mutation decreasing interaction strength:352-352(569661)|mutation decreasing interaction strength:360-360(3282)|mutation disrupting interaction strength:364-364|mutation decreasing interaction strength:535-535(3286)|mutation decreasing interaction strength:538-538(3287)|sufficient binding region:256-590|mutation disrupting interaction strength:46-46	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01082	uniprotkb:P35240-3	intact:EBI-351561|intact:EBI-1642531|uniprotkb:O60837|uniprotkb:Q16057|uniprotkb:Q53R99|uniprotkb:Q59ER3|uniprotkb:Q8IX99|uniprotkb:B2RP63|ensembl:ENSP00000349259	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	psi-mi:sptb2_human(display_long)|uniprotkb:SPTBN1(gene name)|psi-mi:SPTBN1(display_short)|uniprotkb:SPTB2(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 1(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396800|imex:IM-27465-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003119.2|refseq:NP_842565.2|ensembl:ENSG00000115306(gene)|ensembl:ENST00000356805(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q01082|rcsb pdb:1AA2|rcsb pdb:1BKR|rcsb pdb:3EDV|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9703465|reactome:R-HSA-373753|refseq:XP_005264574.1|refseq:XP_006712150.1|refseq:XP_016860268.1|refseq:XP_016860269.1|refseq:XP_016860270.1|dip:DIP-33182N	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	-	-	-	figure legend:Fig. 2b, 5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/14	rogid:rQJxsoEirg87umLjsEwHcQ0/blQ9606	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rigid:yzGOXXEYqxy4AlcbPYdeT95MhXQ	false	sufficient binding region:1716-1998	necessary binding region:256-469|mutation increasing interaction strength:41-41|mutation decreasing interaction strength:197-197|mutation increasing interaction strength:219-219(449829)|mutation increasing interaction strength:220-220(643102)|mutation increasing interaction strength:273-273|mutation decreasing interaction strength:352-352(569661)|mutation decreasing interaction strength:360-360(3282)|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:535-535(3286)|mutation disrupting interaction strength:538-538(3287)|sufficient binding region:256-590|mutation disrupting interaction strength:46-46	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35240-1	uniprotkb:P35240-3	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Scoles et al. (2002)	pubmed:11779178|imex:IM-27465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397233|imex:IM-27465-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript)	-	-	-	figure legend:Fig. 3, 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/11/05	2020/01/14	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606	rigid:UE0X9hmMNRa22J2wmlH3gZUjLnU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)