#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q07699-1 uniprotkb:P35499 intact:EBI-20974499|ensembl:ENSP00000262631|ensembl:ENSP00000492022 intact:EBI-16813249|ensembl:ENSP00000396320|uniprotkb:Q15478|uniprotkb:Q16447|uniprotkb:Q7Z6B1 psi-mi:q07699-1(display_long)|uniprotkb:SCN1B(gene name)|psi-mi:SCN1B(display_short)|uniprotkb:Beta-1(isoform synonym) psi-mi:scn4a_human(display_long)|uniprotkb:SCN4A(gene name)|psi-mi:SCN4A(display_short)|uniprotkb:SkM1(gene name synonym)|uniprotkb:Sodium channel protein skeletal muscle subunit alpha(gene name synonym)|uniprotkb:Sodium channel protein type IV subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.4(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Pan et al. (2018) pubmed:30190309|imex:IM-26836 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20771084|imex:IM-26836-1|wwpdb:6AGF|emdb:EMD-9617 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105711(gene)|ensembl:ENST00000262631(transcript)|ensembl:ENST00000638536(transcript)|intact:EBI-20771086(isoform-parent) ensembl:ENSG00000007314(gene)|ensembl:ENST00000435607(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0100001"(regulation of skeletal muscle contraction by action potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008052(Na+ channel 4)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|rcsb pdb:6AGF|rcsb pdb:6MBA|rcsb pdb:6MC9|reactome:R-HSA-445095|reactome:R-HSA-5576892|refseq:NP_000325.4 - - - figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line) - 2018/10/10 2018/11/30 rogid:RWE8tBy/SPlVnb/0sQw5iNT0Db49606 rogid:ERlMxkQZwWjHpBRn/wesKCS0d1g9606 rigid:sziVPEtjUDRXXGLp8zQfCK2Iy8M false - strep ii tag:n-n|flag tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination) uniprotkb:Q07699-1 uniprotkb:P35499 intact:EBI-20974499|ensembl:ENSP00000262631|ensembl:ENSP00000492022 intact:EBI-16813249|ensembl:ENSP00000396320|uniprotkb:Q15478|uniprotkb:Q16447|uniprotkb:Q7Z6B1 psi-mi:q07699-1(display_long)|uniprotkb:SCN1B(gene name)|psi-mi:SCN1B(display_short)|uniprotkb:Beta-1(isoform synonym) psi-mi:scn4a_human(display_long)|uniprotkb:SCN4A(gene name)|psi-mi:SCN4A(display_short)|uniprotkb:SkM1(gene name synonym)|uniprotkb:Sodium channel protein skeletal muscle subunit alpha(gene name synonym)|uniprotkb:Sodium channel protein type IV subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.4(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pan et al. (2018) pubmed:30190309|imex:IM-26836 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20976567|wwpdb:6AGF|emdb:EMD-9617|imex:IM-26836-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105711(gene)|ensembl:ENST00000262631(transcript)|ensembl:ENST00000638536(transcript)|intact:EBI-20771086(isoform-parent) ensembl:ENSG00000007314(gene)|ensembl:ENST00000435607(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030424"(axon)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0100001"(regulation of skeletal muscle contraction by action potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008052(Na+ channel 4)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|rcsb pdb:6AGF|rcsb pdb:6MBA|rcsb pdb:6MC9|reactome:R-HSA-445095|reactome:R-HSA-5576892|refseq:NP_000325.4 - - - figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line) - 2018/10/10 2018/11/24 rogid:RWE8tBy/SPlVnb/0sQw5iNT0Db49606 rogid:ERlMxkQZwWjHpBRn/wesKCS0d1g9606 rigid:sziVPEtjUDRXXGLp8zQfCK2Iy8M false - strep ii tag:n-n|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)