#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96D42 uniprotkb:P01876 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218254|imex:IM-26398-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome) - - - figure legend:Figure 4B|comment:Experiments proved that IgA-lambda binds specifically to the Ig-like domain of HAVCR1/TIM1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Mystbtg9uttxFXl//LGdoM32po09606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false flag tag:c-c|sufficient binding region:21..21-294..294|fc-igg tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q96D42 uniprotkb:P0DOX8 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-20218279 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igl1_human(display_long)|uniprotkb:Immunoglobulin lambda-1 light chain MCG(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218254|imex:IM-26398-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0019814"(immunoglobulin complex) - - - figure legend:Figure 4B|comment:Experiments proved that IgA-lambda binds specifically to the Ig-like domain of HAVCR1/TIM1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Rxis+CGwuXLM7BJ2UpzID/YvxUk9606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false flag tag:c-c|sufficient binding region:21..21-294..294|fc-igg tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q96D42 uniprotkb:P01876 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218691|imex:IM-26398-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome) - - - figure legend:"Figure 4A (2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Mystbtg9uttxFXl//LGdoM32po09606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false sufficient binding region:21..21-294..294|fc-igg tag:c-c|flag tag:c-c - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96D42 uniprotkb:P0DOX8 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-20218279 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igl1_human(display_long)|uniprotkb:Immunoglobulin lambda-1 light chain MCG(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218691|imex:IM-26398-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0019814"(immunoglobulin complex) - - - figure legend:"Figure 4A (2)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Rxis+CGwuXLM7BJ2UpzID/YvxUk9606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false sufficient binding region:21..21-294..294|fc-igg tag:c-c|flag tag:c-c - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96D42 uniprotkb:P0DOX8 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-20218279 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igl1_human(display_long)|uniprotkb:Immunoglobulin lambda-1 light chain MCG(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218792|imex:IM-26398-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0019814"(immunoglobulin complex) - - - figure legend:Figure 6|comment:Experiments proved that IgA-lambda binds specifically to the Ig-like domain of HAVCR1/TIM1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Rxis+CGwuXLM7BJ2UpzID/YvxUk9606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false flag tag:c-c|sufficient binding region:21..21-294..294|fc-igg tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q96D42 uniprotkb:P01876 intact:EBI-953786|ensembl:ENSP00000344844|ensembl:ENSP00000427898|uniprotkb:O43656 intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021 psi-mi:havr1_human(display_long)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T-cell membrane protein 1(gene name synonym)|uniprotkb:HAVCR1(gene name)|psi-mi:HAVCR1(display_short)|uniprotkb:TIM1(gene name synonym)|uniprotkb:TIMD1(gene name synonym)|uniprotkb:KIM1(gene name synonym)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym) psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Tami et al. (2007) imex:IM-26398|pubmed:17229699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-20218792|imex:IM-26398-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113249(gene)|ensembl:ENST00000339252(transcript)|ensembl:ENST00000523175(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0033005"(positive regulation of mast cell activation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZO|rcsb pdb:5F70|refseq:NP_001166864.1|refseq:NP_036338.2|refseq:NP_001295085.1 ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome) - - - figure legend:Figure 6|comment:Experiments proved that IgA-lambda binds specifically to the Ig-like domain of HAVCR1/TIM1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/04/30 2019/04/15 rogid:PhE6jN/FMK3/rhbSTXsFyN23PE89606 rogid:Mystbtg9uttxFXl//LGdoM32po09606 rigid:qJIM32X8nKkMMbZkayHy+uTkBh4 false flag tag:c-c|sufficient binding region:21..21-294..294|fc-igg tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)