#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01728	uniprotkb:Q01728	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q6AYT3	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7622129|intact:MINT-4576391|uniprotkb:Q6PX76|ensembl:ENSRNOP00000006570	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:rtcb_rat(display_long)|uniprotkb:Rtcb(gene name)|psi-mi:Rtcb(display_short)|uniprotkb:p55(gene name synonym)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:NP_997497.1|rgd:1303261|ensembl:ENSRNOG00000004813(gene)|ensembl:ENSRNOT00000006570(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q6AYT3	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:ISQNiLQA7DCcgBkTueMDhUHrkFQ10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q07439	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7621383|intact:MINT-240978|uniprotkb:P42853|uniprotkb:Q63256|uniprotkb:P0DMW0|uniprotkb:P0DMW1	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:hsp71_rat(display_long)|uniprotkb:Hspa1a(gene name)|psi-mi:Hspa1a(display_short)|uniprotkb:Hsp70-1(gene name synonym)|uniprotkb:Hspa1(gene name synonym)|uniprotkb:Hspa1b(gene name)|psi-mi:Hspa1b(display_short)|uniprotkb:Hsp70-2(gene name synonym)|uniprotkb:Hspa2(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	reactome:REACT_196424|refseq:NP_114177.2|go:"GO:0043234"|refseq:NP_997669.1|interpro:IPR018181|rgd:2840|rgd:1593284|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0016607"(nuclear speck)|go:"GO:0016323"(basolateral plasma membrane)|interpro:IPR013126(Heat shock protein 70)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|reactome:REACT_206546|reactome:REACT_216105|reactome:REACT_216489|ensembl:ENSRNOG00000045654|ensembl:ENSRNOG00000050647|ensembl:ENSRNOP00000050605|ensembl:ENSRNOP00000067749|go:"GO:0002931"(response to ischemia)|go:"GO:0009314"(response to radiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|interpro:IPR029047|interpro:IPR029048|ensembl:ENSRNOT00000049667|ensembl:ENSRNOT00000061950|go:"GO:0001106"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|refseq:NP_001316825.1|refseq:XP_017457331.1|ensembl:ENSRNOT00000081924|ensembl:ENSRNOP00000075599|reactome:R-RNO-3371453|reactome:R-RNO-3371497|reactome:R-RNO-3371568|reactome:R-RNO-3371571|reactome:R-RNO-450408|reactome:R-RNO-6798695|go:"GO:0005813"(centrosome)|go:"GO:0045121"(membrane raft)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0042026"(protein refolding)|go:"GO:1901673"(regulation of mitotic spindle assembly)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:IAXBQEhz+98PlZVipstiFb8KoL810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q63470	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P62961	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-917053|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|uniprotkb:Q4KMA4	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ybox1_rat(display_long)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Yb1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:61843|refseq:NP_113751.3|interpro:IPR019844|interpro:IPR011129(Cold shock protein)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-RNO-72163|reactome:R-RNO-72165|reactome:R-RNO-9017802|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035198"(miRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:imkViHICtFj/0wQ8IDprza1b43010116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0U1RS25	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423836|ensembl:ENSRNOP00000075905	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0u1rs25_rat(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1589127|ensembl:ENSRNOG00000020134(gene)|ensembl:ENSRNOT00000092446(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|reactome:R-RNO-975956|reactome:R-RNO-975957|refseq:XP_003751614.1|refseq:XP_003752928.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:R7zWqEAD8bukcETEps9H5tTyoYI10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q63537	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-1638355|uniprotkb:Q9Z1H0	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P38656	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-15649175	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:la_rat(display_long)|uniprotkb:Ssb(gene name)|psi-mi:Ssb(display_short)|uniprotkb:Ss-b(gene name synonym)|uniprotkb:La autoantigen homolog(gene name synonym)|uniprotkb:La ribonucleoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0000049"(tRNA binding)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0008033"(tRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0071045"(nuclear histone mRNA catabolic process)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|rgd:620804|dip:DIP-46500N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:oD+XBSjVVERjwRhNKvEHob/WZzM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D3ZWC6	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423816|ensembl:ENSRNOP00000006423	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d3zwc6_rat(display_long)|uniprotkb:Sntb1(gene name)|psi-mi:Sntb1(display_short)|uniprotkb:Sntb1_predicted(gene name synonym)|uniprotkb:rCG_60073(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1307728|ensembl:ENSRNOG00000004821(gene)|ensembl:ENSRNOT00000006423(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|refseq:NP_001124014.1|refseq:XP_017450243.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:RvdinbDtD/DuxSiBRmY0hp+y0Dk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P60123	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-917815|uniprotkb:O35753|ensembl:ENSRNOP00000018339|ensembl:ENSRNOP00000075190	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ruvb1_rat(display_long)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:68373|refseq:NP_671706.1|refseq:XP_006236927.1|ensembl:ENSRNOG00000013195(gene)|ensembl:ENSRNOT00000018339(transcript)|ensembl:ENSRNOT00000090875(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60123|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-5696394|reactome:R-RNO-606279|interpro:IPR027238	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:B5DFF2	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423798|ensembl:ENSRNOP00000021337|ensembl:ENSRNOP00000070734|uniprotkb:F1M9N3	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:b5dff2_rat(display_long)|uniprotkb:Rbpms2(gene name)|psi-mi:Rbpms2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1561222|ensembl:ENSRNOG00000015896(gene)|ensembl:ENSRNOT00000021337(transcript)|ensembl:ENSRNOT00000081375(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034787|interpro:IPR035979|refseq:NP_001166897.1|refseq:XP_006243336.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:IV+UJ06PjCxyrAHDS0TD1ldGqmE10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P36876	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16120980|ensembl:ENSRNOP00000015318|uniprotkb:A1A5M9|uniprotkb:O35512|uniprotkb:P36878	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:2aba_rat(display_long)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform BRA(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|reactome:R-RNO-2995383|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-975957|ensembl:ENSRNOG00000011158(gene)|ensembl:ENSRNOT00000015318(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|refseq:NP_446451.1|rgd:620919|dip:DIP-40819N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:xKS7KF5010Toh9AHo43Kt7AysQo10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q923S8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423784	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pank4_rat(display_long)|uniprotkb:Pank4(gene name)|psi-mi:Pank4(display_short)|uniprotkb:Fang1(gene name synonym)|uniprotkb:Inactive pantothenic acid kinase 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:628857|reactome:R-RNO-196783|go:"GO:0004594"(pantothenate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_598215.1|interpro:IPR035073|interpro:IPR002791(Protein of unknown function DUF89)|interpro:IPR015844(Pantothenate kinase, acetyl-CoA regulated, two-domain type)|interpro:IPR004567(Eukaryotic pantothenate kinase)|interpro:IPR036075|interpro:IPR043129	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:HTQ3l6p0mQ20hyQODUzVMhgHKdw10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q9EPH8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-919825|ensembl:ENSRNOP00000012775	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pabp1_rat(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:619838|refseq:NP_599180.1|ensembl:ENSRNOG00000008639(gene)|ensembl:ENSRNOT00000012775(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q9EPH8|reactome:R-RNO-156827|reactome:R-RNO-429947|reactome:R-RNO-450408|reactome:R-RNO-72649|reactome:R-RNO-975956|reactome:R-RNO-975957	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:SEu6ZUy3fI2xh8x9pqs+9OCtt+M10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4A478	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423767|ensembl:ENSRNOP00000026965	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4a478_rat(display_long)|uniprotkb:Ntpcr(gene name)|psi-mi:Ntpcr(display_short)|uniprotkb:RGD1306192_predicted(gene name synonym)|uniprotkb:rCG_50896(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1306192|ensembl:ENSRNOG00000019922(gene)|ensembl:ENSRNOT00000026965(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|interpro:IPR027417|refseq:NP_001128045.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:yoUI//5jC5E7/UjdXwDgS/D43ZM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4A7F2	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423755|ensembl:ENSRNOP00000023354	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4a7f2_rat(display_long)|uniprotkb:Mycbp(gene name)|psi-mi:Mycbp(display_short)|uniprotkb:rCG_31143(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:2320727|ensembl:ENSRNOG00000017166(gene)|ensembl:ENSRNOT00000023354(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007283"(spermatogenesis)|interpro:IPR026060|refseq:NP_001258253.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:giUYDjBm16KI4fVDEi/bRdoJMdk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P43244	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16220483|uniprotkb:O35833|uniprotkb:Q5DVW1	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:matr3_rat(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)|uniprotkb:Nuclear scaffold protein p130/MAT3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P43244|rgd:3052|refseq:NP_062022.2|refseq:XP_006254596.1|refseq:XP_017456375.1|refseq:XP_017456376.1|interpro:IPR034928|interpro:IPR034930|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR035979	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:cIeIMjPK3/Ejwo7M0bBIRomzo+810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P04041	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423727|uniprotkb:O08946|uniprotkb:Q4PIY2|uniprotkb:Q91WZ5	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:gpx1_rat(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0035094"(response to nicotine)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|reactome:R-RNO-2142712|reactome:R-RNO-2142770|reactome:R-RNO-3299685|refseq:NP_110453.3|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|rgd:2729|interpro:IPR036249	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:VTSRtPjW3PSfpTKCHRvAM4HjDdc10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q9WVH8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423691|ensembl:ENSRNOP00000007004|ensembl:ENSRNOP00000069614|uniprotkb:Q9R284	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:fbln5_rat(display_long)|uniprotkb:Fbln5(gene name)|psi-mi:Fbln5(display_short)|uniprotkb:Dance(gene name synonym)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Embryonic vascular EGF repeat-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000050539(gene)|ensembl:ENSRNOT00000007004(transcript)|ensembl:ENSRNOT00000084815(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098867"(intramembranous bone growth)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|reactome:R-RNO-1566948|reactome:R-RNO-2129379|refseq:NP_062026.2|rgd:2594	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:Q2kjLvo1xUq4cBUciDalkn//xoo10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q5FWT1	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-920789|ensembl:ENSRNOP00000042004	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:fa98a_rat(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1305486|refseq:NP_001014095.1|ensembl:ENSRNOG00000030328(gene)|ensembl:ENSRNOT00000052131(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q5FWT1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:4cL2E54a+iywa7RlPa4l8iroPa810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4AB03	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16219891|ensembl:ENSRNOP00000057305	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4ab03_rat(display_long)|uniprotkb:Fam120a(gene name)|psi-mi:Fam120a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000016779(gene)|ensembl:ENSRNOT00000060568(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR026784|interpro:IPR029060|rgd:1306643	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:DoVq7nmS+p0QJfmjrW6JIUi2yoI10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2K9H9	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423673|ensembl:ENSRNOP00000075003	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2k9h9_rat(display_long)|uniprotkb:Dnajb5(gene name)|psi-mi:Dnajb5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000000130(gene)|ensembl:ENSRNOT00000080082(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|go:"GO:0005829"(cytosol)|rgd:1307453	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:uSzpvuIOZLRQ/v5VOvYRm/kvg5Y10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q5XIP0	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-920407|uniprotkb:F1LNN0|ensembl:ENSRNOP00000017381|ensembl:ENSRNOP00000075386	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:q5xip0_rat(display_long)|uniprotkb:Dnajb4(gene name)|psi-mi:Dnajb4(display_short)|uniprotkb:rCG_28476(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1305826|refseq:NP_001013094.1|refseq:XP_008759772.1|refseq:XP_006233550.1|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|ensembl:ENSRNOG00000013011(gene)|ensembl:ENSRNOT00000017381(transcript)|ensembl:ENSRNOT00000086878(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:mvXSDlVog9Y+VG/Cb+t6EPzzmMM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2K5E4	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423632|ensembl:ENSRNOP00000073394	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2k5e4_rat(display_long)|uniprotkb:Dnaja3(gene name)|psi-mi:Dnaja3(display_short)|uniprotkb:rCG_49803(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000003855(gene)|ensembl:ENSRNOT00000085230(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|refseq:XP_006245879.1|rgd:1306527	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:wS041endZnT/AgoFPafWeJY2eZk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P11530	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-706166|ensembl:ENSRNOP00000029969|uniprotkb:F1M705	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:dmd_rat(display_long)|uniprotkb:Dmd(gene name)|psi-mi:Dmd(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000046366(gene)|ensembl:ENSRNOT00000035692(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005840"(ribosome)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008307"(structural constituent of muscle)|rgd:2507|refseq:XP_017457399.1|go:"GO:0009414"(response to water deprivation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014809"(regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014904"(myotube cell development)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0017022"(myosin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0021629"(olfactory nerve structural organization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034622"|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055001"(muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060857"(establishment of glial blood-brain barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0090287"(regulation of cellular response to growth factor stimulus)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099617"(matrix side of mitochondrial inner membrane)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|reactome:R-RNO-390522	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:+tB82I1CIAu/nuaXmqNoSWqLp0o10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q641Y8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-931609|ensembl:ENSRNOP00000009100	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ddx1_rat(display_long)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:619903|refseq:NP_445866.1|ensembl:ENSRNOG00000006652(gene)|ensembl:ENSRNOT00000009100(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:xBtxoTUBcxlxSlczX+ni1kieU+010116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2JYE0	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423613|ensembl:ENSRNOP00000070616	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2jye0_rat(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000018686(gene)|ensembl:ENSRNOT00000080605(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|rgd:1565868	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:yBRAJ3FWb+eHow2GgKzHa3b426410116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P84092	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q08602	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-9010423|ensembl:ENSRNOP00000049261	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pgta_rat(display_long)|uniprotkb:Rabggta(gene name)|psi-mi:Rabggta(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym)|uniprotkb:Ggta(gene name synonym)|uniprotkb:Rab geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Rab geranylgeranyltransferase subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423604|imex:IM-26257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:NP_113842.1|rgd:621697|refseq:XP_006252071.1|refseq:XP_006252072.1|dip:DIP-6137N|ensembl:ENSRNOG00000030483(gene)|ensembl:ENSRNOT00000048455(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR032675|interpro:IPR032955|interpro:IPR036254|rcsb pdb:1DCE|rcsb pdb:1LTX|rcsb pdb:3C72|rcsb pdb:3DSS|rcsb pdb:3DST|rcsb pdb:3DSU|rcsb pdb:3DSV|rcsb pdb:3DSW|rcsb pdb:3DSX|rcsb pdb:3HXB|rcsb pdb:3HXC|rcsb pdb:3HXD|rcsb pdb:3HXE|rcsb pdb:3HXF|rcsb pdb:3PZ1|rcsb pdb:3PZ2|rcsb pdb:3PZ3|rcsb pdb:4EHM|rcsb pdb:4GTS|rcsb pdb:4GTT|rcsb pdb:4GTV|reactome:R-RNO-6803205|reactome:R-RNO-8873719	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart-ventricle-left)|taxid:10116(Rat heart ventricle left)	-	2017/09/19	2017/10/04	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:Bna8uv2Rydf7bdelX6oA9dADOAE10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q01728	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q6AYT3	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7622129|intact:MINT-4576391|uniprotkb:Q6PX76|ensembl:ENSRNOP00000006570	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:rtcb_rat(display_long)|uniprotkb:Rtcb(gene name)|psi-mi:Rtcb(display_short)|uniprotkb:p55(gene name synonym)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:NP_997497.1|rgd:1303261|ensembl:ENSRNOG00000004813(gene)|ensembl:ENSRNOT00000006570(transcript)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q6AYT3	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:ISQNiLQA7DCcgBkTueMDhUHrkFQ10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q07439	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7621383|intact:MINT-240978|uniprotkb:P42853|uniprotkb:Q63256|uniprotkb:P0DMW0|uniprotkb:P0DMW1	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:hsp71_rat(display_long)|uniprotkb:Hspa1a(gene name)|psi-mi:Hspa1a(display_short)|uniprotkb:Hsp70-1(gene name synonym)|uniprotkb:Hspa1(gene name synonym)|uniprotkb:Hspa1b(gene name)|psi-mi:Hspa1b(display_short)|uniprotkb:Hsp70-2(gene name synonym)|uniprotkb:Hspa2(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	reactome:REACT_196424|refseq:NP_114177.2|go:"GO:0043234"|refseq:NP_997669.1|interpro:IPR018181|rgd:2840|rgd:1593284|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0016607"(nuclear speck)|go:"GO:0016323"(basolateral plasma membrane)|interpro:IPR013126(Heat shock protein 70)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|reactome:REACT_206546|reactome:REACT_216105|reactome:REACT_216489|ensembl:ENSRNOG00000045654|ensembl:ENSRNOG00000050647|ensembl:ENSRNOP00000050605|ensembl:ENSRNOP00000067749|go:"GO:0002931"(response to ischemia)|go:"GO:0009314"(response to radiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|interpro:IPR029047|interpro:IPR029048|ensembl:ENSRNOT00000049667|ensembl:ENSRNOT00000061950|go:"GO:0001106"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|refseq:NP_001316825.1|refseq:XP_017457331.1|ensembl:ENSRNOT00000081924|ensembl:ENSRNOP00000075599|reactome:R-RNO-3371453|reactome:R-RNO-3371497|reactome:R-RNO-3371568|reactome:R-RNO-3371571|reactome:R-RNO-450408|reactome:R-RNO-6798695|go:"GO:0005813"(centrosome)|go:"GO:0045121"(membrane raft)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0042026"(protein refolding)|go:"GO:1901673"(regulation of mitotic spindle assembly)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:IAXBQEhz+98PlZVipstiFb8KoL810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q63470	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P62961	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-917053|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|uniprotkb:Q4KMA4	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ybox1_rat(display_long)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Yb1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:61843|refseq:NP_113751.3|interpro:IPR019844|interpro:IPR011129(Cold shock protein)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-RNO-72163|reactome:R-RNO-72165|reactome:R-RNO-9017802|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035198"(miRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:imkViHICtFj/0wQ8IDprza1b43010116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0U1RS25	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423836|ensembl:ENSRNOP00000075905	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0u1rs25_rat(display_long)|uniprotkb:Upf1(gene name)|psi-mi:Upf1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1589127|ensembl:ENSRNOG00000020134(gene)|ensembl:ENSRNOT00000092446(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|reactome:R-RNO-975956|reactome:R-RNO-975957|refseq:XP_003751614.1|refseq:XP_003752928.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:R7zWqEAD8bukcETEps9H5tTyoYI10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q63537	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-1638355|uniprotkb:Q9Z1H0	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:syn2_rat(display_long)|uniprotkb:Syn2(gene name)|psi-mi:Syn2(display_short)|uniprotkb:Synapsin II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:3798|refseq:NP_001029192.1|refseq:NP_062032.1|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR001359(Synapsin)|interpro:IPR020898|interpro:IPR019735|interpro:IPR019736|interpro:IPR020897|mint:Q63537|interpro:IPR028712|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099504"(synaptic vesicle cycle)|rcsb pdb:1I7L|rcsb pdb:1I7N|reactome:R-RNO-181429|reactome:R-RNO-212676	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:/uqCXVO2VdZfAgfc9c8dwJQcUOY10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P38656	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-15649175	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:la_rat(display_long)|uniprotkb:Ssb(gene name)|psi-mi:Ssb(display_short)|uniprotkb:Ss-b(gene name synonym)|uniprotkb:La autoantigen homolog(gene name synonym)|uniprotkb:La ribonucleoprotein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0000049"(tRNA binding)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0008033"(tRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0071045"(nuclear histone mRNA catabolic process)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|rgd:620804|dip:DIP-46500N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:oD+XBSjVVERjwRhNKvEHob/WZzM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D3ZWC6	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423816|ensembl:ENSRNOP00000006423	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d3zwc6_rat(display_long)|uniprotkb:Sntb1(gene name)|psi-mi:Sntb1(display_short)|uniprotkb:Sntb1_predicted(gene name synonym)|uniprotkb:rCG_60073(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1307728|ensembl:ENSRNOG00000004821(gene)|ensembl:ENSRNOT00000006423(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|refseq:NP_001124014.1|refseq:XP_017450243.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:RvdinbDtD/DuxSiBRmY0hp+y0Dk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P60123	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-917815|uniprotkb:O35753|ensembl:ENSRNOP00000018339|ensembl:ENSRNOP00000075190	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ruvb1_rat(display_long)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:68373|refseq:NP_671706.1|refseq:XP_006236927.1|ensembl:ENSRNOG00000013195(gene)|ensembl:ENSRNOT00000018339(transcript)|ensembl:ENSRNOT00000090875(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60123|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-5696394|reactome:R-RNO-606279|interpro:IPR027238	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:B5DFF2	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423798|ensembl:ENSRNOP00000021337|ensembl:ENSRNOP00000070734|uniprotkb:F1M9N3	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:b5dff2_rat(display_long)|uniprotkb:Rbpms2(gene name)|psi-mi:Rbpms2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1561222|ensembl:ENSRNOG00000015896(gene)|ensembl:ENSRNOT00000021337(transcript)|ensembl:ENSRNOT00000081375(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034787|interpro:IPR035979|refseq:NP_001166897.1|refseq:XP_006243336.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:IV+UJ06PjCxyrAHDS0TD1ldGqmE10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P36876	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16120980|ensembl:ENSRNOP00000015318|uniprotkb:A1A5M9|uniprotkb:O35512|uniprotkb:P36878	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:2aba_rat(display_long)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform BRA(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|reactome:R-RNO-2995383|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-975957|ensembl:ENSRNOG00000011158(gene)|ensembl:ENSRNOT00000015318(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|refseq:NP_446451.1|rgd:620919|dip:DIP-40819N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:xKS7KF5010Toh9AHo43Kt7AysQo10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q923S8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423784	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pank4_rat(display_long)|uniprotkb:Pank4(gene name)|psi-mi:Pank4(display_short)|uniprotkb:Fang1(gene name synonym)|uniprotkb:Inactive pantothenic acid kinase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:628857|reactome:R-RNO-196783|go:"GO:0004594"(pantothenate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_598215.1|interpro:IPR035073|interpro:IPR002791(Protein of unknown function DUF89)|interpro:IPR015844(Pantothenate kinase, acetyl-CoA regulated, two-domain type)|interpro:IPR004567(Eukaryotic pantothenate kinase)|interpro:IPR036075|interpro:IPR043129	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:HTQ3l6p0mQ20hyQODUzVMhgHKdw10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q9EPH8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-919825|ensembl:ENSRNOP00000012775	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pabp1_rat(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:619838|refseq:NP_599180.1|ensembl:ENSRNOG00000008639(gene)|ensembl:ENSRNOT00000012775(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q9EPH8|reactome:R-RNO-156827|reactome:R-RNO-429947|reactome:R-RNO-450408|reactome:R-RNO-72649|reactome:R-RNO-975956|reactome:R-RNO-975957	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:SEu6ZUy3fI2xh8x9pqs+9OCtt+M10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4A478	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423767|ensembl:ENSRNOP00000026965	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4a478_rat(display_long)|uniprotkb:Ntpcr(gene name)|psi-mi:Ntpcr(display_short)|uniprotkb:RGD1306192_predicted(gene name synonym)|uniprotkb:rCG_50896(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1306192|ensembl:ENSRNOG00000019922(gene)|ensembl:ENSRNOT00000026965(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|interpro:IPR027417|refseq:NP_001128045.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:yoUI//5jC5E7/UjdXwDgS/D43ZM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P43244	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16220483|uniprotkb:O35833|uniprotkb:Q5DVW1	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:matr3_rat(display_long)|uniprotkb:Matr3(gene name)|psi-mi:Matr3(display_short)|uniprotkb:Nuclear scaffold protein p130/MAT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0001825"(blastocyst formation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P43244|rgd:3052|refseq:NP_062022.2|refseq:XP_006254596.1|refseq:XP_017456375.1|refseq:XP_017456376.1|interpro:IPR034928|interpro:IPR034930|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR035979	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:cIeIMjPK3/Ejwo7M0bBIRomzo+810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4A7F2	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423755|ensembl:ENSRNOP00000023354	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4a7f2_rat(display_long)|uniprotkb:Mycbp(gene name)|psi-mi:Mycbp(display_short)|uniprotkb:rCG_31143(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:2320727|ensembl:ENSRNOG00000017166(gene)|ensembl:ENSRNOT00000023354(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007283"(spermatogenesis)|interpro:IPR026060|refseq:NP_001258253.1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:giUYDjBm16KI4fVDEi/bRdoJMdk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P04041	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423727|uniprotkb:O08946|uniprotkb:Q4PIY2|uniprotkb:Q91WZ5	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:gpx1_rat(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0005829"(cytosol)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0035094"(response to nicotine)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|reactome:R-RNO-2142712|reactome:R-RNO-2142770|reactome:R-RNO-3299685|refseq:NP_110453.3|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|rgd:2729|interpro:IPR036249	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:VTSRtPjW3PSfpTKCHRvAM4HjDdc10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q9WVH8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423691|ensembl:ENSRNOP00000007004|ensembl:ENSRNOP00000069614|uniprotkb:Q9R284	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:fbln5_rat(display_long)|uniprotkb:Fbln5(gene name)|psi-mi:Fbln5(display_short)|uniprotkb:Dance(gene name synonym)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Embryonic vascular EGF repeat-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000050539(gene)|ensembl:ENSRNOT00000007004(transcript)|ensembl:ENSRNOT00000084815(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098867"(intramembranous bone growth)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|reactome:R-RNO-1566948|reactome:R-RNO-2129379|refseq:NP_062026.2|rgd:2594	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:Q2kjLvo1xUq4cBUciDalkn//xoo10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q5FWT1	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-920789|ensembl:ENSRNOP00000042004	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:fa98a_rat(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1305486|refseq:NP_001014095.1|ensembl:ENSRNOG00000030328(gene)|ensembl:ENSRNOT00000052131(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q5FWT1	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:4cL2E54a+iywa7RlPa4l8iroPa810116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:D4AB03	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16219891|ensembl:ENSRNOP00000057305	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:d4ab03_rat(display_long)|uniprotkb:Fam120a(gene name)|psi-mi:Fam120a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000016779(gene)|ensembl:ENSRNOT00000060568(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|interpro:IPR026784|interpro:IPR029060|rgd:1306643	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:DoVq7nmS+p0QJfmjrW6JIUi2yoI10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2K9H9	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423673|ensembl:ENSRNOP00000075003	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2k9h9_rat(display_long)|uniprotkb:Dnajb5(gene name)|psi-mi:Dnajb5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000000130(gene)|ensembl:ENSRNOT00000080082(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|go:"GO:0005829"(cytosol)|rgd:1307453	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:uSzpvuIOZLRQ/v5VOvYRm/kvg5Y10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q5XIP0	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-920407|uniprotkb:F1LNN0|ensembl:ENSRNOP00000017381|ensembl:ENSRNOP00000075386	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:q5xip0_rat(display_long)|uniprotkb:Dnajb4(gene name)|psi-mi:Dnajb4(display_short)|uniprotkb:rCG_28476(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:1305826|refseq:NP_001013094.1|refseq:XP_008759772.1|refseq:XP_006233550.1|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|ensembl:ENSRNOG00000013011(gene)|ensembl:ENSRNOT00000017381(transcript)|ensembl:ENSRNOT00000086878(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:mvXSDlVog9Y+VG/Cb+t6EPzzmMM10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2K5E4	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423632|ensembl:ENSRNOP00000073394	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2k5e4_rat(display_long)|uniprotkb:Dnaja3(gene name)|psi-mi:Dnaja3(display_short)|uniprotkb:rCG_49803(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000003855(gene)|ensembl:ENSRNOT00000085230(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|refseq:XP_006245879.1|rgd:1306527	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:wS041endZnT/AgoFPafWeJY2eZk10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P11530	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-706166|ensembl:ENSRNOP00000029969|uniprotkb:F1M705	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:dmd_rat(display_long)|uniprotkb:Dmd(gene name)|psi-mi:Dmd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000046366(gene)|ensembl:ENSRNOT00000035692(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005840"(ribosome)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008307"(structural constituent of muscle)|rgd:2507|refseq:XP_017457399.1|go:"GO:0009414"(response to water deprivation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014809"(regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014904"(myotube cell development)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0017022"(myosin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0021629"(olfactory nerve structural organization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034622"|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055001"(muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060857"(establishment of glial blood-brain barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0090287"(regulation of cellular response to growth factor stimulus)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099617"(matrix side of mitochondrial inner membrane)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|reactome:R-RNO-390522	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:+tB82I1CIAu/nuaXmqNoSWqLp0o10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q641Y8	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-931609|ensembl:ENSRNOP00000009100	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ddx1_rat(display_long)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	rgd:619903|refseq:NP_445866.1|ensembl:ENSRNOG00000006652(gene)|ensembl:ENSRNOT00000009100(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:xBtxoTUBcxlxSlczX+ni1kieU+010116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:A0A0G2JYE0	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-16423613|ensembl:ENSRNOP00000070616	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:a0a0g2jye0_rat(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	ensembl:ENSRNOG00000018686(gene)|ensembl:ENSRNOT00000080605(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|rgd:1565868	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:yBRAJ3FWb+eHow2GgKzHa3b426410116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:P84092	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q01728	uniprotkb:Q08602	intact:EBI-7400598|intact:MINT-4563844|uniprotkb:Q9QW49|uniprotkb:Q9WU30|uniprotkb:Q9R239|uniprotkb:Q9R238|uniprotkb:Q9WU29|uniprotkb:Q924Y2|ensembl:ENSRNOP00000040751	intact:EBI-9010423|ensembl:ENSRNOP00000049261	psi-mi:nac1_rat(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx1(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pgta_rat(display_long)|uniprotkb:Rabggta(gene name)|psi-mi:Rabggta(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym)|uniprotkb:Ggta(gene name synonym)|uniprotkb:Rab geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Rab geranylgeranyltransferase subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423938|imex:IM-26257-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008762660.1|refseq:XP_008762661.1|refseq:NP_001257703.1|refseq:NP_001257701.1|refseq:NP_001257704.1|rgd:3717|refseq:NP_001257702.1|refseq:NP_001257705.1|refseq:NP_001257706.1|refseq:XP_008762655.1|refseq:XP_008762659.1|refseq:XP_017449552.1|refseq:XP_017449553.1|ensembl:ENSRNOG00000008479(gene)|ensembl:ENSRNOT00000042230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR032452|interpro:IPR038081|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5578775|go:"GO:0098719"(sodium ion import across plasma membrane)	refseq:NP_113842.1|rgd:621697|refseq:XP_006252071.1|refseq:XP_006252072.1|dip:DIP-6137N|ensembl:ENSRNOG00000030483(gene)|ensembl:ENSRNOT00000048455(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR032675|interpro:IPR032955|interpro:IPR036254|rcsb pdb:1DCE|rcsb pdb:1LTX|rcsb pdb:3C72|rcsb pdb:3DSS|rcsb pdb:3DST|rcsb pdb:3DSU|rcsb pdb:3DSV|rcsb pdb:3DSW|rcsb pdb:3DSX|rcsb pdb:3HXB|rcsb pdb:3HXC|rcsb pdb:3HXD|rcsb pdb:3HXE|rcsb pdb:3HXF|rcsb pdb:3PZ1|rcsb pdb:3PZ2|rcsb pdb:3PZ3|rcsb pdb:4EHM|rcsb pdb:4GTS|rcsb pdb:4GTT|rcsb pdb:4GTV|reactome:R-RNO-6803205|reactome:R-RNO-8873719	-	comment:mint|comment:homomint|function:"Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores"	-	figure legend:table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/09/19	2017/11/07	rogid:wa5P7bjtM1XriQxelb/HmCkcGj810116	rogid:Bna8uv2Rydf7bdelX6oA9dADOAE10116	rigid:EialRp7QeKtz0mIxSy2vWXz7RrI	false	sufficient binding region:243-787|his tag:n-n|tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q63470	uniprotkb:P70414	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	intact:EBI-2312694	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16423985|imex:IM-26257-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	-	figure legend:figure 3a|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:xXHyMhhs5gWh2DI1bL0+C5OO3b4	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P36876	intact:EBI-2312694	intact:EBI-16120980|ensembl:ENSRNOP00000015318|uniprotkb:A1A5M9|uniprotkb:O35512|uniprotkb:P36878	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:2aba_rat(display_long)|uniprotkb:Ppp2r2a(gene name)|psi-mi:Ppp2r2a(display_short)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform BRA(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424052|imex:IM-26257-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|reactome:R-RNO-2995383|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-975957|ensembl:ENSRNOG00000011158(gene)|ensembl:ENSRNOT00000015318(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|refseq:NP_446451.1|rgd:620919|dip:DIP-40819N	-	-	-	figure legend:figure 3b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:xKS7KF5010Toh9AHo43Kt7AysQo10116	rigid:a+7FyCXGlihhCWdWXxcSBWxVKBw	false	green fluorescent protein tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:D3ZWC6	uniprotkb:P70414	intact:EBI-16423816|ensembl:ENSRNOP00000006423	intact:EBI-2312694	psi-mi:d3zwc6_rat(display_long)|uniprotkb:Sntb1(gene name)|psi-mi:Sntb1(display_short)|uniprotkb:Sntb1_predicted(gene name synonym)|uniprotkb:rCG_60073(orf name)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424063|imex:IM-26257-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1307728|ensembl:ENSRNOG00000004821(gene)|ensembl:ENSRNOT00000006423(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR036034|interpro:IPR041428|refseq:NP_001124014.1|refseq:XP_017450243.1	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3c|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:RvdinbDtD/DuxSiBRmY0hp+y0Dk10116	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:S0rSEZEPtXYx+UphWFOu6oMooqw	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11532	uniprotkb:P70414	intact:EBI-295827|uniprotkb:Q9UCW3|uniprotkb:Q9UCW4|uniprotkb:Q02295|uniprotkb:Q14169|uniprotkb:Q14170|uniprotkb:Q5JYU0|uniprotkb:Q7KZ48|intact:EBI-11041646|uniprotkb:A1L0U9|uniprotkb:Q8N754|uniprotkb:E9PDN1|uniprotkb:Q6NSJ9|intact:EBI-12189729|intact:EBI-22423597|intact:EBI-12702600|uniprotkb:E7EQR9|uniprotkb:E7EQS5|uniprotkb:E7ESB2|uniprotkb:E9PDN5|uniprotkb:F5GZY3|uniprotkb:F8VX32|intact:EBI-28985510	intact:EBI-2312694	psi-mi:dmd_human(display_long)|uniprotkb:DMD(gene name)|psi-mi:DMD(display_short)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424074|imex:IM-26257-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000100.2|refseq:NP_003997.1|refseq:NP_004000.1|refseq:NP_004001.1|refseq:NP_004002.2|refseq:NP_004003.1|refseq:NP_004004.1|refseq:NP_004005.1|refseq:NP_004008.1|refseq:NP_004009.1|refseq:NP_004010.1|refseq:NP_004011.2|refseq:NP_004012.1|refseq:NP_004013.1|refseq:NP_004014.1|refseq:NP_004006.1|refseq:NP_004007.1|ensembl:ENST00000682600|ensembl:ENSP00000507640|ensembl:ENST00000361471|ensembl:ENSP00000354464|ensembl:ENSG00000198947|ensembl:ENST00000378680|ensembl:ENSP00000367951|ensembl:ENST00000378702|ensembl:ENSP00000367974|ensembl:ENST00000378723|ensembl:ENSP00000367997|mint:P11532|dip:DIP-32593N|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009986"(cell surface)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014809"(regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016013"(syntrophin complex)|go:"GO:0017022"(myosin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034622"|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0090287"(regulation of cellular response to growth factor stimulus)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|rcsb pdb:1DXX|rcsb pdb:1EG3|rcsb pdb:1EG4|rcsb pdb:3UUN|reactome:R-HSA-3000171|reactome:R-HSA-390522	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3d|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:gUFSTsQjsZpAmGI3+6ZPmUebofA9606	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:CV6ZY4lVQValuV4Z9nG/mputiEg	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92696	uniprotkb:P70414	intact:EBI-9104196|uniprotkb:A8K5N2|uniprotkb:D3DS69|ensembl:ENSP00000216840|ensembl:ENSP00000382341|ensembl:ENSP00000494636|ensembl:ENSP00000496595	intact:EBI-2312694	psi-mi:pgta_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym)|uniprotkb:Rab geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:Rab geranylgeranyltransferase subunit alpha(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424085|imex:IM-26257-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004572.3|refseq:NP_878256.1|ensembl:ENSG00000100949(gene)|ensembl:ENSG00000285193(gene)|ensembl:ENST00000216840(transcript)|ensembl:ENST00000399409(transcript)|ensembl:ENST00000644383(transcript)|ensembl:ENST00000646658(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR032675|interpro:IPR032955|interpro:IPR036254|reactome:R-HSA-6803205|reactome:R-HSA-8873719	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3e|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:oPWV+8Ppm2LhrEekspnRE/9YSK09606	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:LpPvE9z1NjS7xwPWUYKQEVewsVk	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UDY4	uniprotkb:P70414	intact:EBI-356960|uniprotkb:Q13431|uniprotkb:B2R824|ensembl:ENSP00000359799	intact:EBI-2312694	psi-mi:dnjb4_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:DNAJW(gene name synonym)|uniprotkb:HLJ1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1 homolog(gene name synonym)|uniprotkb:Human liver DnaJ-like protein(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424096|imex:IM-26257-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008965.2|refseq:NP_001304028.1|refseq:NP_001304029.1|refseq:NP_001304030.1|refseq:NP_001304031.1|refseq:NP_001304032.1|ensembl:ENSG00000162616(gene)|ensembl:ENST00000370763(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009408"(response to heat)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UDY4	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3f|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:gN0zBtJQiTN+YYSAtMk1mddNWLU9606	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:yTWGpo9d0CghksFQ4B+afull9yU	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5U2U8	uniprotkb:P70414	intact:EBI-12593069|ensembl:ENSRNOP00000027616	intact:EBI-2312694	psi-mi:q5u2u8_rat(display_long)|uniprotkb:Bag3(gene name)|psi-mi:Bag3(display_short)|uniprotkb:rCG_40209(orf name)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424107|imex:IM-26257-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000020298(gene)|ensembl:ENSRNOT00000027616(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0101031"(chaperone complex)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|reactome:R-RNO-3371453|refseq:NP_001011936.1|rgd:1307794	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3g|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:JSJXC6nDlp17hMWSL3Sfry390ho10116	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:gBTEpo3IMhmmkivUU6CLytA7nrc	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q62865	intact:EBI-2312694	intact:EBI-16424126|ensembl:ENSRNOP00000032282	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:pde3a_rat(display_long)|uniprotkb:Pde3a(gene name)|psi-mi:Pde3a(display_short)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424118|imex:IM-26257-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	rgd:61942|ensembl:ENSRNOG00000025042(gene)|ensembl:ENSRNOT00000032843(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004112"(cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0060282"(positive regulation of oocyte development)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|reactome:R-RNO-418555|refseq:NP_059033.1	-	-	-	figure legend:figure 3h|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:sEDrcEVP/PpnkNtVN0YQXJ1N9iA10116	rigid:ENYP5D1PF1ITm26wn1SH4L+FbPM	false	green fluorescent protein tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6P722	uniprotkb:P70414	intact:EBI-16424172|ensembl:ENSRNOP00000071721	intact:EBI-2312694	psi-mi:q6p722_rat(display_long)|uniprotkb:Popdc2(gene name)|psi-mi:Popdc2(display_short)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424164|imex:IM-26257-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:735226|ensembl:ENSRNOG00000058752(gene)|ensembl:ENSRNOT00000087892(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030552"(cAMP binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0060931"(sinoatrial node cell development)|interpro:IPR006916(Popeye protein conserved region)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|refseq:NP_954544.1	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3i|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:MCvGK/M0AguEyx3UlYY6C+ZXG9010116	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:26UwvljZ+Xb/r4glUs1IY/0SoQU	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88506	uniprotkb:P70414	intact:EBI-16424196|ensembl:ENSRNOP00000034162|uniprotkb:O70541	intact:EBI-2312694	psi-mi:stk39_rat(display_long)|uniprotkb:Stk39(gene name)|psi-mi:Stk39(display_short)|uniprotkb:Pask(gene name synonym)|uniprotkb:Spak(gene name synonym)|uniprotkb:Pancreatic serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 39(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424188|imex:IM-26257-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621643|ensembl:ENSRNOG00000024808(gene)|ensembl:ENSRNOT00000037133(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050801"(ion homeostasis)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1905408"(negative regulation of creatine transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|go:"GO:0046777"(protein autophosphorylation)|refseq:NP_062235.1	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3j|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:199wH8kr3fXWmVajViOoHGLclEw10116	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:RlTrsOLVkOi94y4cYNLmYDdRJUo	false	flag tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P70414	intact:EBI-2312694	intact:EBI-2312694	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lubelwana et al. (2017)	imex:IM-26257|pubmed:28755400	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16424248|imex:IM-26257-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:figure 3k|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/09/19	2017/10/04	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rigid:7snffBo3g0StyjXtHcQeCvs6gbc	false	green fluorescent protein tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)