#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99963-1	uniprotkb:Q70E73	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-3940924|uniprotkb:Q9C0I2|uniprotkb:Q96Q37|ensembl:ENSP00000316543	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:raph1_human(display_long)|uniprotkb:RAPH1(gene name)|psi-mi:RAPH1(display_short)|uniprotkb:ALS2CR18(gene name synonym)|uniprotkb:ALS2CR9(gene name synonym)|uniprotkb:KIAA1681(gene name synonym)|uniprotkb:LPD(gene name synonym)|uniprotkb:PREL2(gene name synonym)|uniprotkb:RMO1(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein(gene name synonym)|uniprotkb:Lamellipodin(gene name synonym)|uniprotkb:Proline-rich EVH1 ligand 2(gene name synonym)|uniprotkb:Protein RMO1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16133894|imex:IM-24317-1|dip:DIP-198885E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	refseq:NP_976241.1|refseq:NP_998754.1|ensembl:ENST00000308091|ensembl:ENSP00000311293|ensembl:ENSP00000316543|ensembl:ENST00000418114|ensembl:ENSP00000396711|ensembl:ENST00000419464|ensembl:ENSP00000390578|ensembl:ENST00000423104|ensembl:ENSP00000397751|ensembl:ENST00000439222|ensembl:ENSP00000411138|ensembl:ENST00000453034|ensembl:ENSP00000406662|dip:DIP-61336N|ensembl:ENSG00000173166(gene)|ensembl:ENST00000319170(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016604"(nuclear body)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0048675"(axon extension)|interpro:IPR000159(Ras-association)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR039664|interpro:IPR039665|rcsb pdb:4GMV|rcsb pdb:4GN1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:gvrXafpck5vbLuP/cmMV69yJgzs9606	rigid:9vymNhlKmX3lTtfG8tJPDoqdQ+Q	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34971	uniprotkb:Q99962	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16133919|imex:IM-24317-2|dip:DIP-198872E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:SKkHyGxx7hiphl82MMvZsiC2Rl4	false	sufficient binding region:246-315|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99961-1	uniprotkb:P08173	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16133944|imex:IM-24317-3|dip:DIP-198898E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	rigid:P2xeMNVRgxgwcoVtqj42t0vkQvw	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:217-401|enhanced green fluorescent protein tag:c-c|mutation decreasing interaction strength:230-230|mutation decreasing interaction strength:256-256,255-255|mutation decreasing interaction strength:330-330	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08173	uniprotkb:Q99962	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16133980|imex:IM-24317-4|dip:DIP-198879E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:eJtyBQIsfwTKwsES0KwBs5u66DQ	false	sufficient binding region:217-401|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99963-1	uniprotkb:P08913	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134005|imex:IM-24317-5|dip:DIP-198891E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2020/01/08	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:PiuoqnCEJ2iw98/M0lIO/oXqHKI	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:233-389|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:Q70E73	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-3940924|uniprotkb:Q9C0I2|uniprotkb:Q96Q37|ensembl:ENSP00000316543	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:raph1_human(display_long)|uniprotkb:RAPH1(gene name)|psi-mi:RAPH1(display_short)|uniprotkb:ALS2CR18(gene name synonym)|uniprotkb:ALS2CR9(gene name synonym)|uniprotkb:KIAA1681(gene name synonym)|uniprotkb:LPD(gene name synonym)|uniprotkb:PREL2(gene name synonym)|uniprotkb:RMO1(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein(gene name synonym)|uniprotkb:Lamellipodin(gene name synonym)|uniprotkb:Proline-rich EVH1 ligand 2(gene name synonym)|uniprotkb:Protein RMO1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134057|imex:IM-24317-7|dip:DIP-198884E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	refseq:NP_976241.1|refseq:NP_998754.1|ensembl:ENST00000308091|ensembl:ENSP00000311293|ensembl:ENSP00000316543|ensembl:ENST00000418114|ensembl:ENSP00000396711|ensembl:ENST00000419464|ensembl:ENSP00000390578|ensembl:ENST00000423104|ensembl:ENSP00000397751|ensembl:ENST00000439222|ensembl:ENSP00000411138|ensembl:ENST00000453034|ensembl:ENSP00000406662|dip:DIP-61336N|ensembl:ENSG00000173166(gene)|ensembl:ENST00000319170(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016604"(nuclear body)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0048675"(axon extension)|interpro:IPR000159(Ras-association)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR039664|interpro:IPR039665|rcsb pdb:4GMV|rcsb pdb:4GN1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:gvrXafpck5vbLuP/cmMV69yJgzs9606	rigid:UmRhmRn9A8eLCNMHjfzUr+J033c	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99963-1	uniprotkb:P39052	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-349613|ensembl:ENSRNOP00000010948	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:dyn2_rat(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134032|imex:IM-24317-6|dip:DIP-198904E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	rgd:2513|refseq:NP_037331.1|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0005768"(endosome)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005813"(centrosome)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|ensembl:ENSRNOG00000007649(gene)|ensembl:ENSRNOT00000010947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39052|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-203641|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-8856828|interpro:IPR001849(Pleckstrin-like)|refseq:XP_006242670.1|refseq:XP_006242674.1|refseq:XP_006242675.1|dip:DIP-33275N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:3wEwbCVrr/RKqmxXaZ4PJRjl+v810116	rigid:/aZbvWfPiQVbH57Q7lHN+EbcJcA	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13945	uniprotkb:Q99962	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134082|imex:IM-24317-8|dip:DIP-198873E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:jQ+cIsh0y8BEvPl0ybfuekRPRlI	false	sufficient binding region:225-295|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99961-1	uniprotkb:P35462-1	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-15999448	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:p35462-1(display_long)|uniprotkb:DRD3(gene name)|psi-mi:DRD3(display_short)|uniprotkb:Dopamine D3 receptor(gene name synonym)|uniprotkb:D3(isoform synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134164|imex:IM-24317-11|dip:DIP-198893E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	intact:EBI-16356101(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:l5/B7k9gwAfB52rB6m76b6LT2rc9606	rigid:UD+rpcUg/p2fudkchd4eOKXKncE	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:210-329|enhanced green fluorescent protein tag:c-c|mutation decreasing interaction strength:293-293|mutation decreasing interaction strength:318-318	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUM4	uniprotkb:Q99961-1	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	intact:EBI-15691604|ensembl:ENSP00000269886	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134134|imex:IM-24317-10|dip:DIP-198866E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rigid:osmOmTjNBuP4rr6/0TMdzJ06M7U	false	sufficient binding region:717-868|mutation decreasing interaction strength:757-757|enhanced green fluorescent protein tag:c-c	sufficient binding region:306-365|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99963-1	uniprotkb:P08173	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134107|imex:IM-24317-9|dip:DIP-198899E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	rigid:6T/PRhlIp3HqQYpFVYifVK7HVB8	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:217-401|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:P39052	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-349613|ensembl:ENSRNOP00000010948	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:dyn2_rat(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134196|imex:IM-24317-12|dip:DIP-198903E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	rgd:2513|refseq:NP_037331.1|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0005768"(endosome)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005813"(centrosome)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|ensembl:ENSRNOG00000007649(gene)|ensembl:ENSRNOT00000010947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39052|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-203641|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-8856828|interpro:IPR001849(Pleckstrin-like)|refseq:XP_006242670.1|refseq:XP_006242674.1|refseq:XP_006242675.1|dip:DIP-33275N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:3wEwbCVrr/RKqmxXaZ4PJRjl+v810116	rigid:mo/bDPro0yBklYFIlWY5rQp3b4w	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:P08172	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134271|imex:IM-24317-15|dip:DIP-198897E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	rigid:fmlrlAiVWWaE0S+chlla8yoDNZ8	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:208-388|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08913	uniprotkb:Q99962	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134246|imex:IM-24317-14|dip:DIP-198874E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2020/01/08	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:/qr9KmnBiTiu8241ZnB7w9i3czc	false	sufficient binding region:233-389|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35367	uniprotkb:Q99962	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134221|imex:IM-24317-13|dip:DIP-198880E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:vwG55PGMgd1Jx597hmvopmxlxg0	false	sufficient binding region:211-418|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P34971	uniprotkb:Q99961-1	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-15691604|ensembl:ENSP00000269886	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134298|imex:IM-24317-16|dip:DIP-198886E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rigid:eTxWWZXVDfhPz6YOhWiubgtDKXg	false	sufficient binding region:246-315|enhanced green fluorescent protein tag:c-c|mutation decreasing interaction strength:271-271|mutation decreasing interaction strength:273-273,272-272|mutation decreasing interaction strength:299-299,298-298|mutation disrupting interaction strength:284-284,283-283,273-273,272-272	sufficient binding region:306-365|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:P18089	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134342|imex:IM-24317-17|dip:DIP-198892E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:wD58jj343lgoMJQZDBLLT3clak49606	rigid:HLw1qEF38gP8yRXcvI7p69z+HRc	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:194-372|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13945	uniprotkb:Q99961-1	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	intact:EBI-15691604|ensembl:ENSP00000269886	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134428|imex:IM-24317-20|dip:DIP-198888E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rigid:nkx7Z3F/N1gFKLR/iuclsOCeCss	false	sufficient binding region:225-295|enhanced green fluorescent protein tag:c-c	sufficient binding region:306-365|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P18089	uniprotkb:Q99962	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134403|imex:IM-24317-19|dip:DIP-198875E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:wD58jj343lgoMJQZDBLLT3clak49606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:9CLCEMnU/nK7xnD5rPSBAyW0VN8	false	sufficient binding region:194-372|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y5N1-1	uniprotkb:Q99962	intact:EBI-16134369|ensembl:ENSP00000342560	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:q9y5n1-1(display_long)|uniprotkb:HRH3(gene name)|psi-mi:HRH3(display_short)|uniprotkb:GPCR97(gene name synonym)|uniprotkb:G-protein coupled receptor 97(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134376|imex:IM-24317-18|dip:DIP-198881E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101180(gene)|ensembl:ENST00000340177(transcript)|intact:EBI-6626124(isoform-parent)	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:SXyMPoRgJlcfEl9djDo6Qw2yctE9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:YSaYZ/T1ni8cpf1s0kQXBivXVVY	false	sufficient binding region:218-359|enhanced green fluorescent protein tag:?-?	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P39052	uniprotkb:Q99962	intact:EBI-349613|ensembl:ENSRNOP00000010948	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:dyn2_rat(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134482|imex:IM-24317-22|dip:DIP-198882E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2513|refseq:NP_037331.1|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0005768"(endosome)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005813"(centrosome)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|ensembl:ENSRNOG00000007649(gene)|ensembl:ENSRNOT00000010947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39052|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-203641|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-8856828|interpro:IPR001849(Pleckstrin-like)|refseq:XP_006242670.1|refseq:XP_006242674.1|refseq:XP_006242675.1|dip:DIP-33275N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:3wEwbCVrr/RKqmxXaZ4PJRjl+v810116	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:becwHcWNeTC3fUkSajkG5mDa+PM	false	enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99961-1	uniprotkb:P35367	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134455|imex:IM-24317-21|dip:DIP-198901E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	rigid:f48t3AgIbt99V5uoRKCVSG3kQBw	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:211-418|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99963-1	uniprotkb:P35462-1	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-15999448	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:p35462-1(display_long)|uniprotkb:DRD3(gene name)|psi-mi:DRD3(display_short)|uniprotkb:Dopamine D3 receptor(gene name synonym)|uniprotkb:D3(isoform synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134505|imex:IM-24317-23|dip:DIP-198894E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	intact:EBI-16356101(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:l5/B7k9gwAfB52rB6m76b6LT2rc9606	rigid:iXtRWqCI/7F9TTT7btU65bZyESI	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:210-329|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q70E73	uniprotkb:Q99962	intact:EBI-3940924|uniprotkb:Q9C0I2|uniprotkb:Q96Q37|ensembl:ENSP00000316543	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:raph1_human(display_long)|uniprotkb:RAPH1(gene name)|psi-mi:RAPH1(display_short)|uniprotkb:ALS2CR18(gene name synonym)|uniprotkb:ALS2CR9(gene name synonym)|uniprotkb:KIAA1681(gene name synonym)|uniprotkb:LPD(gene name synonym)|uniprotkb:PREL2(gene name synonym)|uniprotkb:RMO1(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein(gene name synonym)|uniprotkb:Lamellipodin(gene name synonym)|uniprotkb:Proline-rich EVH1 ligand 2(gene name synonym)|uniprotkb:Protein RMO1(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134532|imex:IM-24317-24|dip:DIP-198883E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_976241.1|refseq:NP_998754.1|ensembl:ENST00000308091|ensembl:ENSP00000311293|ensembl:ENSP00000316543|ensembl:ENST00000418114|ensembl:ENSP00000396711|ensembl:ENST00000419464|ensembl:ENSP00000390578|ensembl:ENST00000423104|ensembl:ENSP00000397751|ensembl:ENST00000439222|ensembl:ENSP00000411138|ensembl:ENST00000453034|ensembl:ENSP00000406662|dip:DIP-61336N|ensembl:ENSG00000173166(gene)|ensembl:ENST00000319170(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016604"(nuclear body)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0048675"(axon extension)|interpro:IPR000159(Ras-association)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR039664|interpro:IPR039665|rcsb pdb:4GMV|rcsb pdb:4GN1	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:gvrXafpck5vbLuP/cmMV69yJgzs9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:T2GbKFVD6QKrib8Y5qPS7u4XW5A	false	enhanced green fluorescent protein tag:n-n	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P34971	uniprotkb:Q99963-1	intact:EBI-7764182|ensembl:ENSMUSP00000040847|uniprotkb:B2RVY4|intact:UNK-5376537	intact:EBI-16133882|ensembl:ENSP00000391372	psi-mi:adrb1_mouse(display_long)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134580|imex:IM-24317-26|dip:DIP-198887E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035283(gene)|ensembl:ENSMUST00000038949(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P34971|reactome:R-MMU-390696|reactome:R-MMU-418555|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|refseq:NP_031445.2|dip:DIP-59567N	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:dj37utBcHAaPRbEypLNUA/CgH5k10090	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rigid:lrKqOp+Q27kexVOf5b7CTSklM0Q	false	sufficient binding region:246-315|enhanced green fluorescent protein tag:c-c	sufficient binding region:285-344|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35462-1	uniprotkb:Q99962	intact:EBI-15999448	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:p35462-1(display_long)|uniprotkb:DRD3(gene name)|psi-mi:DRD3(display_short)|uniprotkb:Dopamine D3 receptor(gene name synonym)|uniprotkb:D3(isoform synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134555|imex:IM-24317-25|dip:DIP-198876E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-16356101(isoform-parent)	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:l5/B7k9gwAfB52rB6m76b6LT2rc9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:g0scWXodszkIsRdw9Z9BEE1Asrk	false	sufficient binding region:210-329|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99963-1	uniprotkb:P35367	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134607|imex:IM-24317-27|dip:DIP-198902E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	rigid:yKsRdZ5rMq+nBacCeehj5b+7FwU	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:211-418|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51436	uniprotkb:Q99962	intact:EBI-16134634|ensembl:ENSMUSP00000026569|uniprotkb:O35838|uniprotkb:Q7TT80|uniprotkb:Q8BXS4	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:drd4_mouse(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134684|imex:IM-24317-28|dip:DIP-198877E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025496(gene)|ensembl:ENSMUST00000026569(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6IQL|reactome:R-MMU-390651|reactome:R-MMU-418594|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|refseq:NP_031904.1|dip:DIP-61454N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ReecfYMqjdbqAWtnxam7vWTyhfA10090	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:mbtpBoddazhBZ/1azp+XVHAQEZg	false	sufficient binding region:209-314|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99962	uniprotkb:Q99962	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134709|imex:IM-24317-29|dip:DIP-187596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:SRLcWLVc6Dik1EhoEJbey67duPQ	false	myc tag:c-c	green fluorescent protein tag:c-c|sufficient binding region:18-249	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99963-1	uniprotkb:P51436	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-16134634|ensembl:ENSMUSP00000026569|uniprotkb:O35838|uniprotkb:Q7TT80|uniprotkb:Q8BXS4	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:drd4_mouse(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134732|imex:IM-24317-30|dip:DIP-198896E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	ensembl:ENSMUSG00000025496(gene)|ensembl:ENSMUST00000026569(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6IQL|reactome:R-MMU-390651|reactome:R-MMU-418594|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|refseq:NP_031904.1|dip:DIP-61454N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:ReecfYMqjdbqAWtnxam7vWTyhfA10090	rigid:wDYGz+pCvbUR+H1nP5lAyMUy04Y	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:209-314|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:Q9Y5N1-1	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-16134369|ensembl:ENSP00000342560	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:q9y5n1-1(display_long)|uniprotkb:HRH3(gene name)|psi-mi:HRH3(display_short)|uniprotkb:GPCR97(gene name synonym)|uniprotkb:G-protein coupled receptor 97(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134786|imex:IM-24317-32|dip:DIP-198900E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	ensembl:ENSG00000101180(gene)|ensembl:ENST00000340177(transcript)|intact:EBI-6626124(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:SXyMPoRgJlcfEl9djDo6Qw2yctE9606	rigid:q5T982fzdzOd6MH9zr7Xham3n9I	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:218-359|enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99961-1	uniprotkb:P08913	intact:EBI-15691604|ensembl:ENSP00000269886	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134759|imex:IM-24317-31|dip:DIP-198890E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2020/01/08	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:sSGQ6/UY4yj5kMIGUzS542OY2Kc	false	sufficient binding region:306-365|glutathione s tranferase tag:?-?	sufficient binding region:233-389|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51436	uniprotkb:Q99961-1	intact:EBI-16134634|ensembl:ENSMUSP00000026569|uniprotkb:O35838|uniprotkb:Q7TT80|uniprotkb:Q8BXS4	intact:EBI-15691604|ensembl:ENSP00000269886	psi-mi:drd4_mouse(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:q99961-1(display_long)|uniprotkb:SH3GL1(gene name)|psi-mi:SH3GL1(display_short)|uniprotkb:CNSA1(gene name synonym)|uniprotkb:SH3D2B(gene name synonym)|uniprotkb:EEN fusion partner of MLL(gene name synonym)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:Extra eleven-nineteen leukemia fusion gene protein(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134815|imex:IM-24317-33|dip:DIP-198895E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025496(gene)|ensembl:ENSMUST00000026569(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6IQL|reactome:R-MMU-390651|reactome:R-MMU-418594|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|refseq:NP_031904.1|dip:DIP-61454N	intact:EBI-697911(isoform-parent)|ensembl:ENSG00000141985(gene)|ensembl:ENST00000269886(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ReecfYMqjdbqAWtnxam7vWTyhfA10090	rogid:Qzz+R0MGXEpZ6G0xoPglUBKBIfk9606	rigid:3NtA0ejdXOipiWfoFlIIqyInt7Y	false	sufficient binding region:209-314|enhanced green fluorescent protein tag:c-c|mutation decreasing interaction strength:233-233,230-230|mutation disrupting interaction strength:231-232	sufficient binding region:306-365|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08172	uniprotkb:Q99962	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134848|imex:IM-24317-34|dip:DIP-198878E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:b7gQoM1wQg5Fxgt8uaPAR2CPVl0	false	sufficient binding region:208-388|enhanced green fluorescent protein tag:c-c	sufficient binding region:290-349|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99963-1	uniprotkb:P13945	intact:EBI-16133882|ensembl:ENSP00000391372	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	psi-mi:q99963-1(display_long)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)|uniprotkb:EEN-B2-L1(isoform synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boucrot et al. (2015)	pubmed:25517094|doi:10.1038/nature14067|imex:IM-24317	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16134873|imex:IM-24317-35|dip:DIP-198889E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|intact:EBI-473910(isoform-parent)	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	rigid:SqDFjz1jdxsscAUssYMMTGn81qI	false	sufficient binding region:285-344|glutathione s tranferase tag:?-?	sufficient binding region:225-295|enhanced green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)