#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q02647 uniprotkb:P40960 intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C intact:EBI-30551|uniprotkb:Q03398|uniprotkb:D6VTB1|ensemblfungi:YDR488C psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:pac11_yeast(display_long)|uniprotkb:PAC11(gene name)|psi-mi:PAC11(display_short)|uniprotkb:YDR488C(locus name) psi-mi:"MI:0065"(isothermal titration calorimetry) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483363|imex:IM-25799-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) refseq:NP_010776.1|sgd:S000002896|dip:DIP-5268N|mint:P40960|ensemblfungi:YDR488C(gene)|ensemblfungi:YDR488C_mRNA(transcript)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:4HT6 - crc64:C25A690F35C3CEEC crc64:2037021799414E9A figure legend:Fig. 1C, 5C, 5E, Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.2x10^-7(molar) 2017/07/14 2017/07/14 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rogid:ixh39LeDZKLH+1vd1NJ3K8zUg64559292 rigid:UrKkvHwXxq4OSLtPcYPX8WC7zGY false mutation disrupting interaction strength:76-76,78-78|mutation disrupting interaction strength:58-58 sufficient binding region:75-85 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02647 uniprotkb:P40960 intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C intact:EBI-30551|uniprotkb:Q03398|uniprotkb:D6VTB1|ensemblfungi:YDR488C psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:pac11_yeast(display_long)|uniprotkb:PAC11(gene name)|psi-mi:PAC11(display_short)|uniprotkb:YDR488C(locus name) psi-mi:"MI:0114"(x-ray crystallography) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483383|imex:IM-25799-6|wwpdb:4ht6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) refseq:NP_010776.1|sgd:S000002896|dip:DIP-5268N|mint:P40960|ensemblfungi:YDR488C(gene)|ensemblfungi:YDR488C_mRNA(transcript)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:4HT6 - crc64:C25A690F35C3CEEC crc64:2037021799414E9A figure legend:Table 1|3d-resolution:1.9A|3d-r-factors:Rworking 0.16 Rfree 0.212|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/14 2017/07/14 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rogid:ixh39LeDZKLH+1vd1NJ3K8zUg64559292 rigid:UrKkvHwXxq4OSLtPcYPX8WC7zGY false - sufficient binding region:75-85 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02647 uniprotkb:Q02647 intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:"MI:0071"(molecular sieving) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-15483402|imex:IM-25799-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) - crc64:C25A690F35C3CEEC crc64:C25A690F35C3CEEC figure legend:Fig. 5B, supp fig S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/14 2017/07/14 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rigid:ydtlefgLiUpwQWnHzQ+0T9LlChk false mutation with no effect:76-76,78-78|mutation disrupting interaction strength:58-58 mutation with no effect:76-76,78-78|mutation disrupting interaction strength:58-58 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36022 uniprotkb:P40960 intact:EBI-6230|uniprotkb:D6VXB5|ensemblfungi:YKR054C intact:EBI-30551|uniprotkb:Q03398|uniprotkb:D6VTB1|ensemblfungi:YDR488C psi-mi:dyhc_yeast(display_long)|uniprotkb:DYN1(gene name)|psi-mi:DYN1(display_short)|uniprotkb:DHC1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:YKR054C(locus name) psi-mi:pac11_yeast(display_long)|uniprotkb:PAC11(gene name)|psi-mi:PAC11(display_short)|uniprotkb:YDR488C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-15483422|imex:IM-25799-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012980.1|sgd:S000001762|dip:DIP-2644N|mint:P36022|ensemblfungi:YKR054C(gene)|ensemblfungi:YKR054C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000741"(karyogamy)|go:"GO:0005524"(ATP binding)|go:"GO:0005816"(spindle pole body)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|rcsb pdb:3J67|rcsb pdb:3J68|rcsb pdb:3QMZ|rcsb pdb:4AI6|rcsb pdb:4AKG|rcsb pdb:4AKH|rcsb pdb:4AKI|rcsb pdb:4W8F|rcsb pdb:5AFR|rcsb pdb:5VH9|rcsb pdb:5VLJ|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6KJN|rcsb pdb:6KJO|rcsb pdb:7MI1|rcsb pdb:7MI3|rcsb pdb:7MI6|rcsb pdb:7MI8|reactome:R-SCE-6798695 refseq:NP_010776.1|sgd:S000002896|dip:DIP-5268N|mint:P40960|ensemblfungi:YDR488C(gene)|ensemblfungi:YDR488C_mRNA(transcript)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:4HT6 - - crc64:2037021799414E9A figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/07/14 2017/07/15 rogid:ljrJ4uOOw9U/TbVUSL1GoMx8FsA559292 rogid:ixh39LeDZKLH+1vd1NJ3K8zUg64559292 rigid:QuiD3GfhH4fwsrupj575JGCzWwU false zz tag:n-n|green fluorescent protein tag:n-n|ha tag:n-n|tag:c-c myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P36022 uniprotkb:Q02647 intact:EBI-6230|uniprotkb:D6VXB5|ensemblfungi:YKR054C intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C psi-mi:dyhc_yeast(display_long)|uniprotkb:DYN1(gene name)|psi-mi:DYN1(display_short)|uniprotkb:DHC1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:YKR054C(locus name) psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-15483422|imex:IM-25799-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012980.1|sgd:S000001762|dip:DIP-2644N|mint:P36022|ensemblfungi:YKR054C(gene)|ensemblfungi:YKR054C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000741"(karyogamy)|go:"GO:0005524"(ATP binding)|go:"GO:0005816"(spindle pole body)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|rcsb pdb:3J67|rcsb pdb:3J68|rcsb pdb:3QMZ|rcsb pdb:4AI6|rcsb pdb:4AKG|rcsb pdb:4AKH|rcsb pdb:4AKI|rcsb pdb:4W8F|rcsb pdb:5AFR|rcsb pdb:5VH9|rcsb pdb:5VLJ|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6KJN|rcsb pdb:6KJO|rcsb pdb:7MI1|rcsb pdb:7MI3|rcsb pdb:7MI6|rcsb pdb:7MI8|reactome:R-SCE-6798695 refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) - - crc64:C25A690F35C3CEEC figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/07/14 2017/07/15 rogid:ljrJ4uOOw9U/TbVUSL1GoMx8FsA559292 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rigid:QuiD3GfhH4fwsrupj575JGCzWwU false zz tag:n-n|green fluorescent protein tag:n-n|ha tag:n-n|tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40960 uniprotkb:P36022 intact:EBI-30551|uniprotkb:Q03398|uniprotkb:D6VTB1|ensemblfungi:YDR488C intact:EBI-6230|uniprotkb:D6VXB5|ensemblfungi:YKR054C psi-mi:pac11_yeast(display_long)|uniprotkb:PAC11(gene name)|psi-mi:PAC11(display_short)|uniprotkb:YDR488C(locus name) psi-mi:dyhc_yeast(display_long)|uniprotkb:DYN1(gene name)|psi-mi:DYN1(display_short)|uniprotkb:DHC1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:YKR054C(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-15483437|imex:IM-25799-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010776.1|sgd:S000002896|dip:DIP-5268N|mint:P40960|ensemblfungi:YDR488C(gene)|ensemblfungi:YDR488C_mRNA(transcript)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:4HT6 refseq:NP_012980.1|sgd:S000001762|dip:DIP-2644N|mint:P36022|ensemblfungi:YKR054C(gene)|ensemblfungi:YKR054C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000741"(karyogamy)|go:"GO:0005524"(ATP binding)|go:"GO:0005816"(spindle pole body)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|rcsb pdb:3J67|rcsb pdb:3J68|rcsb pdb:3QMZ|rcsb pdb:4AI6|rcsb pdb:4AKG|rcsb pdb:4AKH|rcsb pdb:4AKI|rcsb pdb:4W8F|rcsb pdb:5AFR|rcsb pdb:5VH9|rcsb pdb:5VLJ|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6KJN|rcsb pdb:6KJO|rcsb pdb:7MI1|rcsb pdb:7MI3|rcsb pdb:7MI6|rcsb pdb:7MI8|reactome:R-SCE-6798695 - crc64:2037021799414E9A - figure legend:Fig. 7A|comment:Interaction observed in DYN2-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/07/14 2017/07/15 rogid:ixh39LeDZKLH+1vd1NJ3K8zUg64559292 rogid:ljrJ4uOOw9U/TbVUSL1GoMx8FsA559292 rigid:sz1FSRg3NB2yJUD0ekHFyAIOws0 false myc tag:?-? zz tag:n-n|green fluorescent protein tag:n-n|ha tag:n-n|tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P36022 uniprotkb:Q02647 intact:EBI-6230|uniprotkb:D6VXB5|ensemblfungi:YKR054C intact:EBI-6240|uniprotkb:D6VT54|ensemblfungi:YDR424C psi-mi:dyhc_yeast(display_long)|uniprotkb:DYN1(gene name)|psi-mi:DYN1(display_short)|uniprotkb:DHC1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:YKR054C(locus name) psi-mi:dyl1_yeast(display_long)|uniprotkb:DYN2(gene name)|psi-mi:DYN2(display_short)|uniprotkb:SLC1(gene name synonym)|uniprotkb:YDR424C(locus name) psi-mi:"MI:0416"(fluorescence microscopy) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-15483822|imex:IM-25799-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012980.1|sgd:S000001762|dip:DIP-2644N|mint:P36022|ensemblfungi:YKR054C(gene)|ensemblfungi:YKR054C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000741"(karyogamy)|go:"GO:0005524"(ATP binding)|go:"GO:0005816"(spindle pole body)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|rcsb pdb:3J67|rcsb pdb:3J68|rcsb pdb:3QMZ|rcsb pdb:4AI6|rcsb pdb:4AKG|rcsb pdb:4AKH|rcsb pdb:4AKI|rcsb pdb:4W8F|rcsb pdb:5AFR|rcsb pdb:5VH9|rcsb pdb:5VLJ|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6KJN|rcsb pdb:6KJO|rcsb pdb:7MI1|rcsb pdb:7MI3|rcsb pdb:7MI6|rcsb pdb:7MI8|reactome:R-SCE-6798695 refseq:NP_010712.1|sgd:S000002832|dip:DIP-6480N|mint:Q02647|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|rcsb pdb:4DS1|rcsb pdb:4HT6|reactome:R-SCE-6798695|ensemblfungi:YDR424C(gene)|ensemblfungi:YDR424C_mRNA(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015031"(protein transport)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:1990429"(peroxisomal importomer complex)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed) - - crc64:C25A690F35C3CEEC figure legend:Fig. 7B, Supp fig 4|comment:TMR labelling of HALO tag.|comment:Colocalization is not observed in the absence of DYN2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/07/14 2017/08/04 rogid:ljrJ4uOOw9U/TbVUSL1GoMx8FsA559292 rogid:VzzUwItKMyp/zI7n/iI7VK4QiEA559292 rigid:QuiD3GfhH4fwsrupj575JGCzWwU false green fluorescent protein tag:n-n|ha tag:n-n|tag:c-c|tetramethyl rhodamine label:c-c - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:P36022 uniprotkb:P40960 intact:EBI-6230|uniprotkb:D6VXB5|ensemblfungi:YKR054C intact:EBI-30551|uniprotkb:Q03398|uniprotkb:D6VTB1|ensemblfungi:YDR488C psi-mi:dyhc_yeast(display_long)|uniprotkb:DYN1(gene name)|psi-mi:DYN1(display_short)|uniprotkb:DHC1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:YKR054C(locus name) psi-mi:pac11_yeast(display_long)|uniprotkb:PAC11(gene name)|psi-mi:PAC11(display_short)|uniprotkb:YDR488C(locus name) psi-mi:"MI:0416"(fluorescence microscopy) Rao et al. (2013) pubmed:23761070|imex:IM-25799 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-15483822|imex:IM-25799-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012980.1|sgd:S000001762|dip:DIP-2644N|mint:P36022|ensemblfungi:YKR054C(gene)|ensemblfungi:YKR054C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000741"(karyogamy)|go:"GO:0005524"(ATP binding)|go:"GO:0005816"(spindle pole body)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|rcsb pdb:3J67|rcsb pdb:3J68|rcsb pdb:3QMZ|rcsb pdb:4AI6|rcsb pdb:4AKG|rcsb pdb:4AKH|rcsb pdb:4AKI|rcsb pdb:4W8F|rcsb pdb:5AFR|rcsb pdb:5VH9|rcsb pdb:5VLJ|rcsb pdb:6KIO|rcsb pdb:6KIQ|rcsb pdb:6KJN|rcsb pdb:6KJO|rcsb pdb:7MI1|rcsb pdb:7MI3|rcsb pdb:7MI6|rcsb pdb:7MI8|reactome:R-SCE-6798695 refseq:NP_010776.1|sgd:S000002896|dip:DIP-5268N|mint:P40960|ensemblfungi:YDR488C(gene)|ensemblfungi:YDR488C_mRNA(transcript)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:4HT6 - - crc64:2037021799414E9A figure legend:Fig. 7B, Supp fig 4|comment:TMR labelling of HALO tag.|comment:Colocalization is not observed in the absence of DYN2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/07/14 2017/08/04 rogid:ljrJ4uOOw9U/TbVUSL1GoMx8FsA559292 rogid:ixh39LeDZKLH+1vd1NJ3K8zUg64559292 rigid:QuiD3GfhH4fwsrupj575JGCzWwU false green fluorescent protein tag:n-n|ha tag:n-n|tag:c-c|tetramethyl rhodamine label:c-c myc tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry)