#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01236	uniprotkb:P16471-1	intact:EBI-6903064|ensembl:ENSP00000302150|uniprotkb:Q15199|uniprotkb:Q92996	intact:EBI-15968347|ensembl:ENSP00000482954	psi-mi:prl_human(display_long)|uniprotkb:PRL(gene name)|psi-mi:PRL(display_short)	psi-mi:p16471-1(display_long)|uniprotkb:PRLR(gene name)|psi-mi:PRLR(display_short)	psi-mi:"MI:0016"(circular dichroism)	Dagil et al. (2012)	pubmed:22325776|doi:10.1016/j.str.2011.12.010|imex:IM-17583	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15968354|imex:IM-17583-1|dip:DIP-188880E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172179(gene)|ensembl:ENST00000306482(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030879"(mammary gland development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1RW5|rcsb pdb:2Q98|rcsb pdb:3D48|rcsb pdb:3EW3|rcsb pdb:3MZG|rcsb pdb:3N06|rcsb pdb:3N0P|rcsb pdb:3NCB|rcsb pdb:3NCC|rcsb pdb:3NCE|rcsb pdb:3NCF|rcsb pdb:3NPZ|reactome:R-HSA-1170546|reactome:R-HSA-977225|reactome:R-HSA-982772|go:"GO:1903489"(positive regulation of lactation)|refseq:NP_000939.1|refseq:NP_001157030.1|dip:DIP-59635N	intact:EBI-476182(isoform-parent)|ensembl:ENSG00000113494(gene)|ensembl:ENST00000618457(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4ojucvdmaBrTTrB4ee/BsXLlv1U9606	rogid:8OGFWTIkQ6jDwUMRBlYZFxyb2Hs9606	rigid:cUq8TtxxKjzsibJKyb49kkJQt4I	false	-	sufficient binding region:1-210	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01236	uniprotkb:P16471-1	intact:EBI-6903064|ensembl:ENSP00000302150|uniprotkb:Q15199|uniprotkb:Q92996	intact:EBI-15968347|ensembl:ENSP00000482954	psi-mi:prl_human(display_long)|uniprotkb:PRL(gene name)|psi-mi:PRL(display_short)	psi-mi:p16471-1(display_long)|uniprotkb:PRLR(gene name)|psi-mi:PRLR(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Dagil et al. (2012)	pubmed:22325776|doi:10.1016/j.str.2011.12.010|imex:IM-17583	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15968373|imex:IM-17583-2|dip:DIP-188880E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172179(gene)|ensembl:ENST00000306482(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030879"(mammary gland development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1RW5|rcsb pdb:2Q98|rcsb pdb:3D48|rcsb pdb:3EW3|rcsb pdb:3MZG|rcsb pdb:3N06|rcsb pdb:3N0P|rcsb pdb:3NCB|rcsb pdb:3NCC|rcsb pdb:3NCE|rcsb pdb:3NCF|rcsb pdb:3NPZ|reactome:R-HSA-1170546|reactome:R-HSA-977225|reactome:R-HSA-982772|go:"GO:1903489"(positive regulation of lactation)|refseq:NP_000939.1|refseq:NP_001157030.1|dip:DIP-59635N	intact:EBI-476182(isoform-parent)|ensembl:ENSG00000113494(gene)|ensembl:ENST00000618457(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4ojucvdmaBrTTrB4ee/BsXLlv1U9606	rogid:8OGFWTIkQ6jDwUMRBlYZFxyb2Hs9606	rigid:cUq8TtxxKjzsibJKyb49kkJQt4I	false	-	sufficient binding region:99-210	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)