#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97299	uniprotkb:P13497-2	intact:EBI-15892646|ensembl:ENSMUSP00000029625|uniprotkb:O08862|uniprotkb:O35297	intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332	psi-mi:sfrp2_mouse(display_long)|uniprotkb:Sfrp2(gene name)|psi-mi:Sfrp2(display_short)|uniprotkb:Sarp1(gene name synonym)|uniprotkb:Sdf5(gene name synonym)|uniprotkb:Protein SDF5(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)	psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	He et al. (2010)	pubmed:21078975|doi:10.1073/pnas.1004708107|imex:IM-17141	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892736|imex:IM-17141-1|dip:DIP-188129E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027996(gene)|ensembl:ENSMUST00000029625(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046546"(development of primary male sexual characteristics)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090175"(regulation of establishment of planar polarity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026558|interpro:IPR036790|interpro:IPR041764|refseq:NP_033170.1|dip:DIP-59486N	ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:l5q5wDzn+lUzcI/dzwnIArxATDM10090	rogid:lObdtVRHmod2GwGddF7d51zcmVE9606	rigid:L6Am65LPSc5UkyEKoHvJfVTdr68	false	flag tag:c-c	sufficient binding region:121-730	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97299	uniprotkb:P13497-2	intact:EBI-15892646|ensembl:ENSMUSP00000029625|uniprotkb:O08862|uniprotkb:O35297	intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332	psi-mi:sfrp2_mouse(display_long)|uniprotkb:Sfrp2(gene name)|psi-mi:Sfrp2(display_short)|uniprotkb:Sarp1(gene name synonym)|uniprotkb:Sdf5(gene name synonym)|uniprotkb:Protein SDF5(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 1(gene name synonym)	psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	He et al. (2010)	pubmed:21078975|doi:10.1073/pnas.1004708107|imex:IM-17141	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892757|imex:IM-17141-2|dip:DIP-188129E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027996(gene)|ensembl:ENSMUST00000029625(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046546"(development of primary male sexual characteristics)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061056"(sclerotome development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061185"(negative regulation of dermatome development)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090175"(regulation of establishment of planar polarity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026558|interpro:IPR036790|interpro:IPR041764|refseq:NP_033170.1|dip:DIP-59486N	ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:l5q5wDzn+lUzcI/dzwnIArxATDM10090	rogid:lObdtVRHmod2GwGddF7d51zcmVE9606	rigid:L6Am65LPSc5UkyEKoHvJfVTdr68	false	sufficient binding region:25-295	sufficient binding region:121-730	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)