#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15554 uniprotkb:Q9H816 intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651 intact:EBI-3508943|uniprotkb:Q9H9E5|ensembl:ENSP00000498042 psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym) psi-mi:dcr1b_human(display_long)|uniprotkb:DCLRE1B(gene name)|psi-mi:DCLRE1B(display_short)|uniprotkb:SNM1B(gene name synonym)|uniprotkb:DNA cross-link repair 1B protein(gene name synonym)|uniprotkb:SNM1 homolog B(gene name synonym)|uniprotkb:Beta-lactamase DCLRE1B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Touzot et al. (2010) pubmed:20479256|doi:10.1073/pnas.0914918107|imex:IM-16415 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15854972|imex:IM-16415-1|dip:DIP-186968E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N go:"GO:0010833"(telomere maintenance via telomere lengthening)|refseq:NP_073747.1|refseq:NP_001306876.1|ensembl:ENSG00000118655(gene)|ensembl:ENST00000650450(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016604"(nuclear body)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|mint:Q9H816|rcsb pdb:3BUA|rcsb pdb:5AHO|rcsb pdb:7A1F|go:"GO:0016233"(telomere capping)|rcsb pdb:7B2X|rcsb pdb:7B9B|reactome:R-HSA-6783310|dip:DIP-42669N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606 rogid:bl5L/CwIn5xCj46ElzYxmctQgjU9606 rigid:zxbesd2FmowEy4uV/CgR0Ipuyps false - necessary binding region:417-532|flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H816 uniprotkb:Q9H816 intact:EBI-3508943|uniprotkb:Q9H9E5|ensembl:ENSP00000498042 intact:EBI-3508943|uniprotkb:Q9H9E5|ensembl:ENSP00000498042 psi-mi:dcr1b_human(display_long)|uniprotkb:DCLRE1B(gene name)|psi-mi:DCLRE1B(display_short)|uniprotkb:SNM1B(gene name synonym)|uniprotkb:DNA cross-link repair 1B protein(gene name synonym)|uniprotkb:SNM1 homolog B(gene name synonym)|uniprotkb:Beta-lactamase DCLRE1B(gene name synonym) psi-mi:dcr1b_human(display_long)|uniprotkb:DCLRE1B(gene name)|psi-mi:DCLRE1B(display_short)|uniprotkb:SNM1B(gene name synonym)|uniprotkb:DNA cross-link repair 1B protein(gene name synonym)|uniprotkb:SNM1 homolog B(gene name synonym)|uniprotkb:Beta-lactamase DCLRE1B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Touzot et al. (2010) pubmed:20479256|doi:10.1073/pnas.0914918107|imex:IM-16415 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15854994|imex:IM-16415-2|dip:DIP-187631E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010833"(telomere maintenance via telomere lengthening)|refseq:NP_073747.1|refseq:NP_001306876.1|ensembl:ENSG00000118655(gene)|ensembl:ENST00000650450(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016604"(nuclear body)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|mint:Q9H816|rcsb pdb:3BUA|rcsb pdb:5AHO|rcsb pdb:7A1F|go:"GO:0016233"(telomere capping)|rcsb pdb:7B2X|rcsb pdb:7B9B|reactome:R-HSA-6783310|dip:DIP-42669N go:"GO:0010833"(telomere maintenance via telomere lengthening)|refseq:NP_073747.1|refseq:NP_001306876.1|ensembl:ENSG00000118655(gene)|ensembl:ENST00000650450(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016604"(nuclear body)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011084(DNA repair metallo-beta-lactamase)|interpro:IPR036866|mint:Q9H816|rcsb pdb:3BUA|rcsb pdb:5AHO|rcsb pdb:7A1F|go:"GO:0016233"(telomere capping)|rcsb pdb:7B2X|rcsb pdb:7B9B|reactome:R-HSA-6783310|dip:DIP-42669N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:bl5L/CwIn5xCj46ElzYxmctQgjU9606 rogid:bl5L/CwIn5xCj46ElzYxmctQgjU9606 rigid:KSJdH/0DZnTI3O6Hh4Q6qvxqYHE false flag tag:n-n|sufficient binding region:1-416 vsv tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)