#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P33151	uniprotkb:P23381	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20010843|doi:10.1038/nsmb.1706|imex:IM-14674	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15822664|imex:IM-14674-1|dip:DIP-103687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:bs5BAGA83Y0KrwGe1mv1vFicP90	false	binding-associated region:48-593|fusion protein:c-c	polyprotein fragment:94-471	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:P23381	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20010843|doi:10.1038/nsmb.1706|imex:IM-14674	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15822687|imex:IM-14674-2|dip:DIP-103687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:bs5BAGA83Y0KrwGe1mv1vFicP90	false	binding-associated region:48-593|fusion protein:c-c|mutation disrupting interaction:51-51|mutation disrupting interaction:49-49|mutation disrupting interaction:51-51,49-49	polyprotein fragment:94-471	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:P23381	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20010843|doi:10.1038/nsmb.1706|imex:IM-14674	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15822720|imex:IM-14674-3|dip:DIP-103687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:bs5BAGA83Y0KrwGe1mv1vFicP90	false	binding-associated region:48-593|fusion protein:c-c	polyprotein fragment:94-471	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:P23381	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20010843|doi:10.1038/nsmb.1706|imex:IM-14674	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15822743|imex:IM-14674-4|dip:DIP-103687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:bs5BAGA83Y0KrwGe1mv1vFicP90	false	binding-associated region:48-593|fusion protein:c-c	polyprotein fragment:94-471|mutation disrupting interaction:310-310|mutation disrupting interaction:172-172|mutation disrupting interaction:161-161|mutation disrupting interaction:194-194,159-159	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6URK6	uniprotkb:P23381	intact:EBI-15822779	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:cadh5_bovin(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2010)	pubmed:20010843|doi:10.1038/nsmb.1706|imex:IM-14674	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15822800|imex:IM-14674-5|dip:DIP-103688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001955"(blood vessel maturation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|refseq:NP_001001601.1|dip:DIP-48767N	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:3FKX/pJU6K5Pqw+/RVR9DjcR6JE9913	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:Fama5+VHoFMCLQPfxx/uh6q49ZE	false	-	polyprotein fragment:94-471|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)