#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96GG9	uniprotkb:Q93034	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13620	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13619	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13618	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13617	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13616	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794078|imex:IM-22460-1|dip:DIP-196178E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rigid:/++/dbPS/mh17OvC1hphSftP/HQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13618-1	uniprotkb:Q96GG9	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794277|imex:IM-22460-8|dip:DIP-196184E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rigid:6kwJVChyiLmzhr5oNCodjFtG65M	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618-1	uniprotkb:Q8IWE4	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794277|imex:IM-22460-8|dip:DIP-196184E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rigid:6kwJVChyiLmzhr5oNCodjFtG65M	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618-1	uniprotkb:Q8IWE4	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794252|imex:IM-22460-7|dip:DIP-196181E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rigid:Fpb9Kw/+MGYsA8BFEBCbywdP46Q	false	flag tag:n-n|mutation disrupting interaction strength:756-756	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61081	uniprotkb:Q96GG9	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794233|imex:IM-22460-6|dip:DIP-196186E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rigid:K17RG15eSXUFuPK+zf/islrnjyQ	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13618-1	uniprotkb:Q8IWE4	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794211|imex:IM-22460-5|dip:DIP-196181E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rigid:Fpb9Kw/+MGYsA8BFEBCbywdP46Q	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GG9	uniprotkb:Q13620	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794179|imex:IM-22460-4|dip:DIP-196185E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606	rigid:Rvg9V1U7xfreYR++tV6RC8Kkyo8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13619	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794179|imex:IM-22460-4|dip:DIP-196185E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606	rigid:Rvg9V1U7xfreYR++tV6RC8Kkyo8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13618	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794179|imex:IM-22460-4|dip:DIP-196185E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rigid:Rvg9V1U7xfreYR++tV6RC8Kkyo8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13617	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794179|imex:IM-22460-4|dip:DIP-196185E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:Rvg9V1U7xfreYR++tV6RC8Kkyo8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96GG9	uniprotkb:Q13616	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794179|imex:IM-22460-4|dip:DIP-196185E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rigid:Rvg9V1U7xfreYR++tV6RC8Kkyo8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13618	uniprotkb:Q8IWE4	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794155|imex:IM-22460-3|dip:DIP-196181E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rigid:Fpb9Kw/+MGYsA8BFEBCbywdP46Q	false	-	ha tag:c-c|mutation disrupting interaction strength:271-271,265-265,241-241	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IWE4	uniprotkb:Q13618	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794136|imex:IM-22460-2|dip:DIP-196180E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rigid:r3z0fbtL9rEBBVfqFC9si5DyMo0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IWE4	uniprotkb:Q13617	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794136|imex:IM-22460-2|dip:DIP-196180E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:r3z0fbtL9rEBBVfqFC9si5DyMo0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IWE4	uniprotkb:Q13616	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794136|imex:IM-22460-2|dip:DIP-196180E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rigid:r3z0fbtL9rEBBVfqFC9si5DyMo0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:P61081	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794302|imex:IM-22460-9|dip:DIP-196187E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	rigid:xNpla5SH4+HWNQZC8wQM0++9X4g	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618-1	uniprotkb:P62877	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794389|imex:IM-22460-13|dip:DIP-196183E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606	rigid:tbM3TaB00Re4kr/aJ5ydU1Y7ROU	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618-1	uniprotkb:Q13618-1	intact:EBI-15794202|ensembl:ENSP00000264414	intact:EBI-15794202|ensembl:ENSP00000264414	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:q13618-1(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)|uniprotkb:Cul-3 Long(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794366|imex:IM-22460-12|dip:DIP-196188E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	intact:EBI-456129(isoform-parent)|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rigid:hoydkxKki/wx1xDXqNDXPcwZ6a4	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IWE4	uniprotkb:P61081	intact:EBI-15794102|ensembl:ENSP00000319482|ensembl:ENSP00000454762|uniprotkb:B3KVY4	intact:EBI-1041660|uniprotkb:O76069|uniprotkb:Q8VC50|ensembl:ENSP00000253023	psi-mi:dcnl3_human(display_long)|uniprotkb:DCUN1D3(gene name)|psi-mi:DCUN1D3(display_short)|uniprotkb:SCCRO3(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 3(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 3(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 3(gene name synonym)	psi-mi:ubc12_human(display_long)|uniprotkb:UBE2M(gene name)|psi-mi:UBE2M(display_short)|uniprotkb:UBC12(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 M(gene name synonym)|uniprotkb:NEDD8 carrier protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794345|imex:IM-22460-11|dip:DIP-196182E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188215(gene)|ensembl:ENST00000324344(transcript)|ensembl:ENST00000563934(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000435"(negative regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GBA|reactome:R-HSA-8951664|refseq:NP_775746.1|dip:DIP-60769N	refseq:NP_003960.1|ensembl:ENSG00000130725(gene)|ensembl:ENST00000253023(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P61081|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:2NVU|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4GAO|rcsb pdb:4P5O|reactome:R-HSA-2173789|reactome:R-HSA-5607761|reactome:R-HSA-5676590|dip:DIP-35679N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:mm1cxzEu3wERC4LSX9V7qT9yB089606	rogid:YfRvkrP+nGQTtjeUsJNDbMm1Nqo9606	rigid:GIZkKvFjzzmZ+tujDTRz2yN8cBQ	false	his tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PH85	uniprotkb:Q93034	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:Q13620	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:Q13619	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:Q13618	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:Q13617	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PH85	uniprotkb:Q13616	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meyer-Schaller et al. (2009)	pubmed:19617556|doi:10.1073/pnas.0812528106|imex:IM-22460	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15794321|imex:IM-22460-10|dip:DIP-196179E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rigid:7xY8Hq5uEo/NGPbYq0Sd6CfXA3E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)