#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-15581898 uniprotkb:Q8WXH5 dip:DIP-29574N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:epor peptide(display_short)|psi-mi:EBI-15581898(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669619|imex:IM-8935-7|dip:DIP-59038E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:kwNnrUtX6kZr+g5i8oSUbKJVWOI-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:i0kDABWIXkxUWNw0A25TCE5gR8I false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669599 uniprotkb:Q8WXH5 dip:DIP-29578N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:jak2 py1007(display_short)|psi-mi:EBI-15669599(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669602|imex:IM-8935-1|dip:DIP-59042E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:iLrDeiWoE88PEpYbETjH5kIUxJA-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:2+LdMMho8DxEGztNFikh1TnPJ2M false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15581878 uniprotkb:Q8WXH5 dip:DIP-29576N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:ghr peptide(display_short)|psi-mi:EBI-15581878(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669656|imex:IM-8935-9|dip:DIP-59040E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:w9mhxA8fJDyc40a+ihr+fMvSf/8-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:O1CfnDEm8CFpzKe/RaJVz5HZ/Pc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669636 uniprotkb:Q8WXH5 dip:DIP-29572N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:egfr py1069(display_short)|psi-mi:EBI-15669636(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669639|imex:IM-8935-8|dip:DIP-59036E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:M9GH0q3dpEnk21CUxDKYF48jKUc-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:s13YRYzJUsxfgLOvszZPdvAu4Kw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14508 intact:EBI-15669750 intact:EBI-617737|ensembl:ENSP00000339428|ensembl:ENSP00000442898|ensembl:ENSP00000447161|ensembl:ENSP00000448815|ensembl:ENSP00000449227|ensembl:ENSP00000481249|uniprotkb:O14542|uniprotkb:O95102|uniprotkb:Q9UKS5|uniprotkb:A8K3D1 dip:DIP-29579N psi-mi:socs2_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 2(gene name synonym)|uniprotkb:CIS2(gene name synonym)|uniprotkb:SSI2(gene name synonym)|uniprotkb:STATI2(gene name synonym)|uniprotkb:SOCS2(gene name)|psi-mi:SOCS2(display_short) psi-mi:kit py568(display_short)|psi-mi:EBI-15669750(display_long) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669753|imex:IM-8935-11|dip:DIP-59047E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000120833(gene)|ensembl:ENST00000340600(transcript)|ensembl:ENST00000536696(transcript)|ensembl:ENST00000549122(transcript)|ensembl:ENST00000551556(transcript)|ensembl:ENST00000622746(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O14508|ensembl:ENST00000549206(transcript)|rcsb pdb:2C9W|rcsb pdb:4JGH|rcsb pdb:5BO4|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-9706369|reactome:R-HSA-982772|refseq:NP_003868.1|refseq:NP_001257396.1|refseq:NP_001257397.1|refseq:NP_001257398.1|refseq:NP_001257399.1|refseq:NP_001257400.1|refseq:XP_016875645.1|dip:DIP-29569N - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:vh/FSp+KisXm9YDUkf26UU7ucgI9606 rogid:o8lZ/joGaIiBTBDCSdZNkAV7mpc-2 rigid:2juct1GsbYc1psmoD0rWOqvOWuk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669750 uniprotkb:Q8WXH5 dip:DIP-29579N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:kit py568(display_short)|psi-mi:EBI-15669750(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669770|imex:IM-8935-12|dip:DIP-59043E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:o8lZ/joGaIiBTBDCSdZNkAV7mpc-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:bMdCn6iD1OoIAaC2NDqpiGL0FDA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669730 uniprotkb:Q8WXH5 dip:DIP-29577N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:gp130 py759(display_short)|psi-mi:EBI-15669730(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669733|imex:IM-8935-10|dip:DIP-59041E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:BO/Mgo9snbps3EF3+FDsIRehtj4-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:XW2hosRhheP6UxJXbM5QPQIuitI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669710 uniprotkb:Q8WXH5 dip:DIP-29573N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:egfr py1092(display_short)|psi-mi:EBI-15669710(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669713|imex:IM-8935-3|dip:DIP-59037E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:1pT97jiG48S8dj5r5C94bjlNj/4-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:zwuG7PDi9A/y360gT6nEJAStPi8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669787 uniprotkb:Q8WXH5 dip:DIP-29581N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:peptide pyinp(display_short)|psi-mi:EBI-15669787(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669790|imex:IM-8935-6|dip:DIP-59045E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:+3e0aOrqnATtIAqqT8m23Z/lA4g-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:cOJd1z0g18Qbyj3U95Q2zgPVJvc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14508 intact:EBI-15669599 intact:EBI-617737|ensembl:ENSP00000339428|ensembl:ENSP00000442898|ensembl:ENSP00000447161|ensembl:ENSP00000448815|ensembl:ENSP00000449227|ensembl:ENSP00000481249|uniprotkb:O14542|uniprotkb:O95102|uniprotkb:Q9UKS5|uniprotkb:A8K3D1 dip:DIP-29578N psi-mi:socs2_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 2(gene name synonym)|uniprotkb:CIS2(gene name synonym)|uniprotkb:SSI2(gene name synonym)|uniprotkb:STATI2(gene name synonym)|uniprotkb:SOCS2(gene name)|psi-mi:SOCS2(display_short) psi-mi:jak2 py1007(display_short)|psi-mi:EBI-15669599(display_long) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669673|imex:IM-8935-4|dip:DIP-59046E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) ensembl:ENSG00000120833(gene)|ensembl:ENST00000340600(transcript)|ensembl:ENST00000536696(transcript)|ensembl:ENST00000549122(transcript)|ensembl:ENST00000551556(transcript)|ensembl:ENST00000622746(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O14508|ensembl:ENST00000549206(transcript)|rcsb pdb:2C9W|rcsb pdb:4JGH|rcsb pdb:5BO4|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|reactome:R-HSA-1266695|reactome:R-HSA-8951664|reactome:R-HSA-9706369|reactome:R-HSA-982772|refseq:NP_003868.1|refseq:NP_001257396.1|refseq:NP_001257397.1|refseq:NP_001257398.1|refseq:NP_001257399.1|refseq:NP_001257400.1|refseq:XP_016875645.1|dip:DIP-29569N - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:vh/FSp+KisXm9YDUkf26UU7ucgI9606 rogid:iLrDeiWoE88PEpYbETjH5kIUxJA-2 rigid:qF4yrFMhnWfq6Ob060FjeLtGxfI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669690 uniprotkb:Q8WXH5 dip:DIP-29580N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:leptinr py1077(display_short)|psi-mi:EBI-15669690(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669693|imex:IM-8935-5|dip:DIP-59044E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:6syHM7W4xECqCeqPYU15yI56EaE-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:F7SNc9OMPItTp8ib19SJIz0NqOQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15669807 uniprotkb:Q8WXH5 dip:DIP-29575N intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:ghr py487(display_short)|psi-mi:EBI-15669807(display_long) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15669810|imex:IM-8935-13|dip:DIP-59039E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:o/g7hzwaGCsYz1O2Quv+fmhB6GM-2 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:JIw2zVyhvdd1tS0YCuFp9FiK5cM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15369-1 uniprotkb:Q15370-1 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15669828|imex:IM-8935-2|dip:DIP-59035E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:bTr98PHSveod4uIvPtKdSH21p4I false sufficient binding region:17-112 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15369-1 uniprotkb:Q8WXH5 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 intact:EBI-3942425|ensembl:ENSP00000341327|ensembl:ENSP00000378855|ensembl:ENSP00000452522 psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:socs4_human(display_long)|uniprotkb:SOCS4(gene name)|psi-mi:SOCS4(display_short)|uniprotkb:SOCS7(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 7(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Bullock et al. (2007) pubmed:17997974|doi:10.1016/j.str.2007.09.016|imex:IM-8935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15669828|imex:IM-8935-2|dip:DIP-59035E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) refseq:XP_011534727.1|refseq:XP_011534728.1|ensembl:ENSG00000180008(gene)|ensembl:ENST00000339298(transcript)|ensembl:ENST00000395472(transcript)|ensembl:ENST00000555846(transcript)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|interpro:IPR028416|interpro:IPR035864|interpro:IPR036036|interpro:IPR036860|interpro:IPR037342|mint:Q8WXH5|rcsb pdb:2IZV|reactome:R-HSA-8939242|refseq:NP_543143.1|refseq:NP_955453.1|dip:DIP-29568N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:rAjFy6HZMxEynJ1fXWLKHW/RWSw9606 rigid:bTr98PHSveod4uIvPtKdSH21p4I false sufficient binding region:17-112 sufficient binding region:274-437 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)