#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q91WC1	uniprotkb:Q5EE38-1	intact:EBI-7051001|ensembl:ENSMUSP00000110986|ensembl:ENSMUSP00000131928|uniprotkb:Q8BUH9|intact:MINT-3379580	intact:EBI-15647355|ensembl:ENSMUSP00000048180	psi-mi:pote1_mouse(display_long)|uniprotkb:Pot1(gene name)|psi-mi:Pot1(display_short)|uniprotkb:Pot1a(gene name synonym)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym)	psi-mi:q5ee38-1(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647360|imex:IM-8977-1|dip:DIP-59089E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029676(gene)|ensembl:ENSMUST00000115330(transcript)|ensembl:ENSMUST00000166445(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032202"(telomere assembly)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051276"(chromosome organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060383"(positive regulation of DNA strand elongation)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1905774"(regulation of DNA helicase activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:1905776"(positive regulation of DNA helicase activity)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|mint:Q91WC1|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:NP_598692.1|dip:DIP-29608N	ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|intact:EBI-6258642(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:eWtXiaGr1uIBoKk4po2tJ+EwGRc10090	rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090	rigid:cWfyMFi83mVoODhzeA+itLiEZds	false	myc tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q91WC1	uniprotkb:Q96AP0	intact:EBI-7051001|ensembl:ENSMUSP00000110986|ensembl:ENSMUSP00000131928|uniprotkb:Q8BUH9|intact:MINT-3379580	intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084	psi-mi:pote1_mouse(display_long)|uniprotkb:Pot1(gene name)|psi-mi:Pot1(display_short)|uniprotkb:Pot1a(gene name synonym)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym)	psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647383|imex:IM-8977-3|dip:DIP-59092E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029676(gene)|ensembl:ENSMUST00000115330(transcript)|ensembl:ENSMUST00000166445(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032202"(telomere assembly)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051276"(chromosome organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060383"(positive regulation of DNA strand elongation)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1905774"(regulation of DNA helicase activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:1905776"(positive regulation of DNA helicase activity)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|mint:Q91WC1|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:NP_598692.1|dip:DIP-29608N	refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2019/09/20	rogid:eWtXiaGr1uIBoKk4po2tJ+EwGRc10090	rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606	rigid:TOU9RdbxZ940GhjEDnYLUjs0gx4	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5EE38-1	uniprotkb:Q3TNS5	intact:EBI-15647355|ensembl:ENSMUSP00000048180	intact:EBI-15647404|ensembl:ENSMUSP00000156746	psi-mi:q5ee38-1(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short)	psi-mi:q3tns5_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647428|imex:IM-8977-7|dip:DIP-59090E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|intact:EBI-6258642(isoform-parent)	ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000233972(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_017173149.1|dip:DIP-29609N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090	rogid:V/Aaqgl10AUftqMMgBHSzT5hB5U10090	rigid:fjMZb8FcxVz3tnQ6OvjwmwEF/Y0	false	ha tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5EE38-1	uniprotkb:Q9NUX5-1	intact:EBI-15647355|ensembl:ENSMUSP00000048180	intact:EBI-15593881|ensembl:ENSP00000350249|ensembl:ENSP00000499290|ensembl:ENSP00000499476|ensembl:ENSP00000499546|ensembl:ENSP00000499635	psi-mi:q5ee38-1(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short)	psi-mi:q9nux5-1(display_long)|uniprotkb:POT1(gene name)|psi-mi:POT1(display_short)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym)|uniprotkb:Variant 1(isoform synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647451|imex:IM-8977-8|dip:DIP-59091E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|intact:EBI-6258642(isoform-parent)	intact:EBI-752420(isoform-parent)|ensembl:ENSG00000128513(gene)|ensembl:ENST00000357628(transcript)|ensembl:ENST00000653241(transcript)|ensembl:ENST00000655761(transcript)|ensembl:ENST00000664366(transcript)|ensembl:ENST00000668382(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090	rogid:h/UEb6TNSNHVB4S0YRgS2oA4ydQ9606	rigid:l4bo5F+xzhOXb0f7yLt0z82R5qg	false	ha tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q91WC1	uniprotkb:Q5EE38-1	intact:EBI-7051001|ensembl:ENSMUSP00000110986|ensembl:ENSMUSP00000131928|uniprotkb:Q8BUH9|intact:MINT-3379580	intact:EBI-15647355|ensembl:ENSMUSP00000048180	psi-mi:pote1_mouse(display_long)|uniprotkb:Pot1(gene name)|psi-mi:Pot1(display_short)|uniprotkb:Pot1a(gene name synonym)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym)	psi-mi:q5ee38-1(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647474|imex:IM-8977-2|dip:DIP-59089E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029676(gene)|ensembl:ENSMUST00000115330(transcript)|ensembl:ENSMUST00000166445(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0032202"(telomere assembly)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051276"(chromosome organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060383"(positive regulation of DNA strand elongation)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1905774"(regulation of DNA helicase activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:1905776"(positive regulation of DNA helicase activity)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|mint:Q91WC1|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|refseq:NP_598692.1|dip:DIP-29608N	ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|intact:EBI-6258642(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:"Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:eWtXiaGr1uIBoKk4po2tJ+EwGRc10090	rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090	rigid:cWfyMFi83mVoODhzeA+itLiEZds	false	myc tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AP0	uniprotkb:Q9NUX5-1	intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084	intact:EBI-15593881|ensembl:ENSP00000350249|ensembl:ENSP00000499290|ensembl:ENSP00000499476|ensembl:ENSP00000499546|ensembl:ENSP00000499635	psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym)	psi-mi:q9nux5-1(display_long)|uniprotkb:POT1(gene name)|psi-mi:POT1(display_short)|uniprotkb:POT1-like telomere end-binding protein(gene name synonym)|uniprotkb:Variant 1(isoform synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647497|imex:IM-8977-6|dip:DIP-59094E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N	intact:EBI-752420(isoform-parent)|ensembl:ENSG00000128513(gene)|ensembl:ENST00000357628(transcript)|ensembl:ENST00000653241(transcript)|ensembl:ENST00000655761(transcript)|ensembl:ENST00000664366(transcript)|ensembl:ENST00000668382(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2019/09/20	rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606	rogid:h/UEb6TNSNHVB4S0YRgS2oA4ydQ9606	rigid:Gh5kuPzGgeSVxD015zBI35MiNiI	false	ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5EE38-1	uniprotkb:Q3TNS5	intact:EBI-15647355|ensembl:ENSMUSP00000048180	intact:EBI-15647404|ensembl:ENSMUSP00000156746	psi-mi:q5ee38-1(display_long)|uniprotkb:Acd(gene name)|psi-mi:Acd(display_short)	psi-mi:q3tns5_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647518|imex:IM-8977-5|dip:DIP-59090E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038000(gene)|ensembl:ENSMUST00000042608(transcript)|intact:EBI-6258642(isoform-parent)	ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000233972(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_017173149.1|dip:DIP-29609N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:9kkTzRYUUEOBzGocwGNnZUrWVWk10090	rogid:V/Aaqgl10AUftqMMgBHSzT5hB5U10090	rigid:fjMZb8FcxVz3tnQ6OvjwmwEF/Y0	false	ha tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AP0	uniprotkb:Q3TNS5	intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084	intact:EBI-15647404|ensembl:ENSMUSP00000156746	psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym)	psi-mi:q3tns5_mouse(display_long)|uniprotkb:Pot1b(gene name)|psi-mi:Pot1b(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hockemeyer et al. (2007)	pubmed:17632522|doi:10.1038/nsmb1270|imex:IM-8977	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647541|imex:IM-8977-4|dip:DIP-59093E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N	ensembl:ENSMUSG00000024174(gene)|ensembl:ENSMUST00000233972(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0007569"(cell aging)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051276"(chromosome organization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR032042|refseq:XP_017173149.1|dip:DIP-29609N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2019/09/20	rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606	rogid:V/Aaqgl10AUftqMMgBHSzT5hB5U10090	rigid:OhFRg7YXODhDw5199ZaPpvuRu0Y	false	ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)