#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23907	uniprotkb:P23907	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Eghiaian et al. (2007)	pubmed:17442756|doi:10.1073/pnas.0607745104|imex:IM-22806	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15632544|imex:IM-22806-1|dip:DIP-196810E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rigid:WxTG+KPHfC+nehfwn1f2eMikRL4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23907	uniprotkb:P23907	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:"MI:0020"(transmission electron microscopy)	Eghiaian et al. (2007)	pubmed:17442756|doi:10.1073/pnas.0607745104|imex:IM-22806	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15632560|imex:IM-22806-2|dip:DIP-196810E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rigid:WxTG+KPHfC+nehfwn1f2eMikRL4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23907	uniprotkb:P23907	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	intact:EBI-7670302|ensembl:ENSOARP00000004991|ensembl:ENSOARP00020014736|uniprotkb:Q712V9|uniprotkb:Q7JGT4|intact:MINT-8302691|uniprotkb:Q5ECG0|uniprotkb:Q712W2|uniprotkb:Q6V654|uniprotkb:Q712W3|uniprotkb:Q6V638	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:prio_sheep(display_long)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)|uniprotkb:SIP(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Eghiaian et al. (2007)	pubmed:17442756|doi:10.1073/pnas.0607745104|imex:IM-22806	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15632576|imex:IM-22806-3|dip:DIP-196810E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	ensembl:ENSOARG00000004668(gene)|ensembl:ENSOARG00020011739(gene)|ensembl:ENSOART00000005076(transcript)|ensembl:ENSOART00020017839(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|rcsb pdb:1G04|rcsb pdb:1M25|rcsb pdb:1S4T|rcsb pdb:1TPX|rcsb pdb:1TQB|rcsb pdb:1UW3|rcsb pdb:1XYU|rcsb pdb:1Y2S|rcsb pdb:2KTM|rcsb pdb:2MV8|rcsb pdb:2MV9|rcsb pdb:2N53|rcsb pdb:2RMV|rcsb pdb:2RMW|rcsb pdb:1TQC|refseq:XP_012043480.1|refseq:NP_001009481.1|dip:DIP-60917N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rogid:fPomMoU1B0DmpirxkyChYPyEC849940	rigid:WxTG+KPHfC+nehfwn1f2eMikRL4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)