#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JMB7	uniprotkb:Q8R418	intact:EBI-8573121|ensembl:ENSMUSP00000083222|intact:UNK-5550589|uniprotkb:A1L325|uniprotkb:A1L324|uniprotkb:Q6NXX0	intact:EBI-2644051|uniprotkb:Q8R419	psi-mi:piwl1_mouse(display_long)|uniprotkb:Piwil1(gene name)|psi-mi:Piwil1(display_short)|uniprotkb:Miwi(gene name synonym)	psi-mi:dicer_mouse(display_long)|uniprotkb:Dicer1(gene name)|psi-mi:Dicer1(display_short)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Mdcr(gene name synonym)|uniprotkb:Double-strand-specific ribonuclease mDCR-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Grivna et al. (2006)	pubmed:16938833|doi:10.1073/pnas.0605506103|imex:IM-23892	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598641|imex:IM-23892-1|dip:DIP-198034E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006504381.1|ensembl:ENSMUSG00000029423(gene)|ensembl:ENSMUST00000086056(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q9JMB7|rcsb pdb:2XFM|rcsb pdb:4P1Z|refseq:NP_067286.1|dip:DIP-59456N	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006396"(RNA processing)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010660"(regulation of muscle cell apoptotic process)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0014835"(myoblast differentiation involved in skeletal muscle regeneration)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051225"(spindle assembly)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061548"(ganglion development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070173"(regulation of enamel mineralization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0071335"(hair follicle cell proliferation)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:2000628"(regulation of miRNA metabolic process)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000999(Ribonuclease III)|go:"GO:0021522"(spinal cord motor neuron differentiation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR044441|rcsb pdb:3C4B|rcsb pdb:3C4T|interpro:IPR038248|dip:DIP-29721N|reactome:R-MMU-203927|reactome:R-MMU-426486	psi-mi:"MI:0465"(dip)	comment:mint|function:"Probable component of some RISC complex (RNA-induced silencing), which plays a role in spermatogenesis and in germ cell production, proliferation and maintenance. RISC complexes mediate RNA cleavage and translational silencing. Overexpression may cause malignant germline development. May be associated with proliferating activity of cancer cells. When suppressed, inhibits the growth of gastric cancer cells and induced cell cycle arrest in G2/M phase. Inhibits endoribonuclease DICER1 activity"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:WuQtdXXnFsLsc0HQKeK7k5wPa0I10090	rogid:WTvPhOwCtJat0OjGAIn33JJ4ZEo10090	rigid:WO/dXFoCLPxdOLhyd/+gjegRt08	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)