#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46734	uniprotkb:P15917	intact:EBI-602462|uniprotkb:Q99441|uniprotkb:Q9UE71|uniprotkb:Q9UE72|uniprotkb:B3KSK7|ensembl:ENSP00000345083	intact:EBI-456923|uniprotkb:Q8KYJ6|uniprotkb:Q933F6|ensemblbacteria:AAT28913	psi-mi:mp2k3_human(display_long)|uniprotkb:MAPK/ERK kinase 3(gene name synonym)|uniprotkb:MAP2K3(gene name)|psi-mi:MAP2K3(display_short)|uniprotkb:MEK3(gene name synonym)|uniprotkb:MKK3(gene name synonym)|uniprotkb:PRKMK3(gene name synonym)|uniprotkb:SKK2(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 2(gene name synonym)	psi-mi:lef_bacan(display_long)|uniprotkb:Anthrax lethal toxin endopeptidase component(gene name synonym)|uniprotkb:lef(gene name)|psi-mi:lef(display_short)|uniprotkb:pXO1-107(locus name)|uniprotkb:BXA0172(locus name)|uniprotkb:GBAA_pXO1_0172(locus name)	psi-mi:"MI:0435"(protease assay)	Guichard et al. (2006)	pubmed:16455799|doi:10.1073/pnas.0510748103|imex:IM-23435	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15566590|imex:IM-23435-1|dip:DIP-197508E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002747.2|refseq:NP_659731.1|refseq:XP_011522261.1|refseq:XP_016880347.1|refseq:XP_016880348.1|refseq:NP_001303261.1|refseq:XP_005256780.1|dip:DIP-34242N|ensembl:ENSG00000034152(gene)|ensembl:ENST00000342679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P46734|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891	refseq:NP_052803.1|refseq:WP_001022097.1|refseq:WP_010890024.1|dip:DIP-29871N|mint:P15917|ensemblbacteria:AAT28913(transcript)|ensemblbacteria:GBAA_pXO1_0172(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0044164"(host cell cytosol)|go:"GO:0090729"(toxin activity)|interpro:IPR003541(Anthrax toxin, lethal/endema factor, N-terminal)|interpro:IPR014781(Anthrax toxin, lethal/endema factor, N- and C-terminal)|interpro:IPR015239(Anthrax toxin, lethal factor, central)|interpro:IPR024079|rcsb pdb:1J7N|rcsb pdb:1JKY|rcsb pdb:1PWP|rcsb pdb:1PWQ|rcsb pdb:1PWU|rcsb pdb:1PWV|rcsb pdb:1PWW|rcsb pdb:1YQY|rcsb pdb:1ZXV|rcsb pdb:2L0R|rcsb pdb:3KWV|rcsb pdb:4DV8|rcsb pdb:4PKQ|rcsb pdb:4PKR|rcsb pdb:4PKS|rcsb pdb:4PKT|rcsb pdb:4PKU|rcsb pdb:4PKV|rcsb pdb:4PKW|rcsb pdb:4WF6|rcsb pdb:4XM6|rcsb pdb:4XM7|rcsb pdb:4XM8|rcsb pdb:5D1S|rcsb pdb:5D1T|rcsb pdb:5D1U|rcsb pdb:6PSN|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|rcsb pdb:6ZXK|rcsb pdb:6ZXL|reactome:R-HSA-5210891	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:OcAgoYfpPPQycfZ6tr52FCRzcOU9606	rogid:HvuMhoQb9eCHIox5O6RIVFknPMc1392	rigid:61G0UuwXT4ZmjbavsMrFv/THQAo	false	35s radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q23977	uniprotkb:P15917	intact:EBI-74214|uniprotkb:O18411|uniprotkb:Q8SZ04|uniprotkb:Q8SZZ1|uniprotkb:Q9I7S3|ensemblmetazoa:FBpp0073578	intact:EBI-456923|uniprotkb:Q8KYJ6|uniprotkb:Q933F6|ensemblbacteria:AAT28913	psi-mi:hep_drome(display_long)|uniprotkb:hep(gene name)|psi-mi:hep(display_short)|uniprotkb:hem(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:CG4353(orf name)	psi-mi:lef_bacan(display_long)|uniprotkb:Anthrax lethal toxin endopeptidase component(gene name synonym)|uniprotkb:lef(gene name)|psi-mi:lef(display_short)|uniprotkb:pXO1-107(locus name)|uniprotkb:BXA0172(locus name)|uniprotkb:GBAA_pXO1_0172(locus name)	psi-mi:"MI:0435"(protease assay)	Guichard et al. (2006)	pubmed:16455799|doi:10.1073/pnas.0510748103|imex:IM-23435	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15566609|imex:IM-23435-2|dip:DIP-197509E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_727661.1|flybase:FBgn0010303|refseq:NP_511142.2|refseq:NP_001259501.1|dip:DIP-30870N|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-209397|reactome:R-DME-209447|reactome:R-DME-350376|go:"GO:0042060"(wound healing)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046528"(imaginal disc fusion)|go:"GO:0046529"(imaginal disc fusion, thorax closure)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046844"(chorion micropyle formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0048675"(axon extension)|go:"GO:0048803"(imaginal disc-derived male genitalia morphogenesis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903688"(positive regulation of border follicle cell migration)|ensemblmetazoa:FBgn0010303(gene)|ensemblmetazoa:FBtr0073747(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007561"(imaginal disc eversion)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030424"(axon)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0034769"(basement membrane disassembly)|go:"GO:0035006"(melanization defense response)|go:"GO:0036335"(intestinal stem cell homeostasis)	refseq:NP_052803.1|refseq:WP_001022097.1|refseq:WP_010890024.1|dip:DIP-29871N|mint:P15917|ensemblbacteria:AAT28913(transcript)|ensemblbacteria:GBAA_pXO1_0172(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0044164"(host cell cytosol)|go:"GO:0090729"(toxin activity)|interpro:IPR003541(Anthrax toxin, lethal/endema factor, N-terminal)|interpro:IPR014781(Anthrax toxin, lethal/endema factor, N- and C-terminal)|interpro:IPR015239(Anthrax toxin, lethal factor, central)|interpro:IPR024079|rcsb pdb:1J7N|rcsb pdb:1JKY|rcsb pdb:1PWP|rcsb pdb:1PWQ|rcsb pdb:1PWU|rcsb pdb:1PWV|rcsb pdb:1PWW|rcsb pdb:1YQY|rcsb pdb:1ZXV|rcsb pdb:2L0R|rcsb pdb:3KWV|rcsb pdb:4DV8|rcsb pdb:4PKQ|rcsb pdb:4PKR|rcsb pdb:4PKS|rcsb pdb:4PKT|rcsb pdb:4PKU|rcsb pdb:4PKV|rcsb pdb:4PKW|rcsb pdb:4WF6|rcsb pdb:4XM6|rcsb pdb:4XM7|rcsb pdb:4XM8|rcsb pdb:5D1S|rcsb pdb:5D1T|rcsb pdb:5D1U|rcsb pdb:6PSN|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|rcsb pdb:6ZXK|rcsb pdb:6ZXL|reactome:R-HSA-5210891	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:XTLY74pOC/Mk9P0Rrq5DSUM+K0w7227	rogid:HvuMhoQb9eCHIox5O6RIVFknPMc1392	rigid:IIqrpkjTsOh6mJrJPdD03SqXA8E	false	35s radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O62602	uniprotkb:P15917	intact:EBI-107946|ensemblmetazoa:FBpp0073551	intact:EBI-456923|uniprotkb:Q8KYJ6|uniprotkb:Q933F6|ensemblbacteria:AAT28913	psi-mi:o62602_drome(display_long)|uniprotkb:lic(gene name)|psi-mi:lic(display_short)|uniprotkb:MKK3(gene name synonym)|uniprotkb:p38MAPKK(gene name synonym)|uniprotkb:Dmel_CG12244(orf name)|uniprotkb:D-MKK3(gene name synonym)|uniprotkb:DMEK3(gene name synonym)|uniprotkb:DMKK3(gene name synonym)|uniprotkb:DmMKK3(gene name synonym)|uniprotkb:Dmel\CG12244(gene name synonym)|uniprotkb:MEK3(gene name synonym)|uniprotkb:Mek3(gene name synonym)|uniprotkb:Mkk3(gene name synonym)|uniprotkb:Mpk3(gene name synonym)|uniprotkb:dMKK3(gene name synonym)|uniprotkb:"l(1)G0252"(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:CG12244(orf name)	psi-mi:lef_bacan(display_long)|uniprotkb:Anthrax lethal toxin endopeptidase component(gene name synonym)|uniprotkb:lef(gene name)|psi-mi:lef(display_short)|uniprotkb:pXO1-107(locus name)|uniprotkb:BXA0172(locus name)|uniprotkb:GBAA_pXO1_0172(locus name)	psi-mi:"MI:0435"(protease assay)	Guichard et al. (2006)	pubmed:16455799|doi:10.1073/pnas.0510748103|imex:IM-23435	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15566628|imex:IM-23435-3|dip:DIP-197510E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477162.1|flybase:FBgn0261524|ensemblmetazoa:FBgn0261524(gene)|ensemblmetazoa:FBtr0073720(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048082"(regulation of adult chitin-containing cuticle pigmentation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-168638|reactome:R-DME-2559580|reactome:R-DME-450302|reactome:R-DME-6811555	refseq:NP_052803.1|refseq:WP_001022097.1|refseq:WP_010890024.1|dip:DIP-29871N|mint:P15917|ensemblbacteria:AAT28913(transcript)|ensemblbacteria:GBAA_pXO1_0172(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0044164"(host cell cytosol)|go:"GO:0090729"(toxin activity)|interpro:IPR003541(Anthrax toxin, lethal/endema factor, N-terminal)|interpro:IPR014781(Anthrax toxin, lethal/endema factor, N- and C-terminal)|interpro:IPR015239(Anthrax toxin, lethal factor, central)|interpro:IPR024079|rcsb pdb:1J7N|rcsb pdb:1JKY|rcsb pdb:1PWP|rcsb pdb:1PWQ|rcsb pdb:1PWU|rcsb pdb:1PWV|rcsb pdb:1PWW|rcsb pdb:1YQY|rcsb pdb:1ZXV|rcsb pdb:2L0R|rcsb pdb:3KWV|rcsb pdb:4DV8|rcsb pdb:4PKQ|rcsb pdb:4PKR|rcsb pdb:4PKS|rcsb pdb:4PKT|rcsb pdb:4PKU|rcsb pdb:4PKV|rcsb pdb:4PKW|rcsb pdb:4WF6|rcsb pdb:4XM6|rcsb pdb:4XM7|rcsb pdb:4XM8|rcsb pdb:5D1S|rcsb pdb:5D1T|rcsb pdb:5D1U|rcsb pdb:6PSN|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|rcsb pdb:6ZXK|rcsb pdb:6ZXL|reactome:R-HSA-5210891	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:+beA7Y2bGsmbJt7030eZmI7UvSU7227	rogid:HvuMhoQb9eCHIox5O6RIVFknPMc1392	rigid:AhCHxdSvQ7qsL2/8RC189XyKwqE	false	35s radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)