#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13569	uniprotkb:O15554	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0655"(lambda repressor two hybrid)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13637914|imex:IM-25718-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	-	-	-	figure legend:Table 1i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2016/12/20	2017/01/26	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:2DDhAUTyqOTKQ2wTv0nWq3qNKKg	false	sufficient binding region:1237-1420(IPR003439)|sufficient binding region:1387-1480	sufficient binding region:1-40|sufficient binding region:345-400	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54619-1	uniprotkb:O15554	intact:EBI-13638144|ensembl:ENSP00000447433	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:p54619-1(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0655"(lambda repressor two hybrid)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638170|imex:IM-25718-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|intact:EBI-1181439(isoform-parent)|uniprotkb:P54619-1(isoform-parent)	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	-	-	-	figure legend:Table 1iv|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2016/12/20	2017/01/26	rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:+JVU3oM5pEaE4TXaINH+GJMO12U	false	sufficient binding region:100-331|sufficient binding region:100-331(IPR003439)	sufficient binding region:1-40|sufficient binding region:345-400	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54619-1	uniprotkb:P13569	intact:EBI-13638144|ensembl:ENSP00000447433	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	psi-mi:p54619-1(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short)	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:"MI:0655"(lambda repressor two hybrid)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638191|imex:IM-25718-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|intact:EBI-1181439(isoform-parent)|uniprotkb:P54619-1(isoform-parent)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	-	-	-	figure legend:Table 1v|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2016/12/20	2017/01/26	rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rigid:5Urr31w/rJxQMHhEPtGa5IvIUd0	false	sufficient binding region:100-331(IPR003439)	sufficient binding region:1387-1480(IPR003439)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13569	uniprotkb:O15554	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638324|imex:IM-25718-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	-	-	-	figure legend:Fig 1 A/C|comment:In cells expressing  CFTR having the Delta-508 CFTR Cystic fibrosis mutation, only an immature form of CFTR, probably with altered glycosylation, is detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-cfbe)|taxid:9606(Homo sapiens)	-	2016/12/20	2017/01/27	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:2DDhAUTyqOTKQ2wTv0nWq3qNKKg	false	mutation decreasing interaction strength:508-508	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13569	uniprotkb:O15554	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638343|imex:IM-25718-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	-	-	-	figure legend:Fig 1 B/D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-cfbe)|taxid:9606(Homo sapiens)	-	2016/12/20	2017/01/27	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:2DDhAUTyqOTKQ2wTv0nWq3qNKKg	false	mutation decreasing interaction strength:508-508	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13569	uniprotkb:O15554	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13638374|imex:IM-25718-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:3, Supp fig 1|agonist:"Ca2+ ions (CHEBI:29108)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-cfbe)|taxid:9606(Homo sapiens)	-	2016/12/20	2017/03/01	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:2DDhAUTyqOTKQ2wTv0nWq3qNKKg	false	enhanced green fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13569	uniprotkb:O15554	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-2924473|ensembl:ENSP00000496939|uniprotkb:Q53XR4	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:kcnn4_human(display_long)|uniprotkb:KCNN4(gene name)|psi-mi:KCNN4(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKCA1(gene name synonym)|uniprotkb:KCA4(gene name synonym)|uniprotkb:SK4(gene name synonym)|uniprotkb:KCa4(gene name synonym)|uniprotkb:KCa3.1(gene name synonym)|uniprotkb:IKCa1(gene name synonym)|uniprotkb:Putative Gardos channel(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Klein et al. (2015)	imex:IM-25718|pubmed:27092946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13918456|imex:IM-25718-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N	ensembl:ENSG00000104783(gene)|ensembl:ENST00000648319(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022894"(Intermediate conductance calcium-activated potassium channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046541"(saliva secretion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6D42|reactome:R-HSA-1296052|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|refseq:NP_002241.1|dip:DIP-48598N	-	-	-	figure legend:3C, 4|agonist:"Ca2+ ions (CHEBI:29108)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-cfbe)|taxid:9606(Homo sapiens)	-	2016/12/20	2017/02/22	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:7nm4ouZmgJFq4s+0NrcNiOxz++k9606	rigid:2DDhAUTyqOTKQ2wTv0nWq3qNKKg	false	enhanced green fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)