#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UHD2	uniprotkb:Q96CV9	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meena et al. (2016)	imex:IM-25518|pubmed:27086836	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12521931|imex:IM-25518-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:f2b f2c|comment:"only a small fraction of optineurin coimmunoprecipitated with TBK1 in unstimulated HEK293-hTLR3 cells, and that binding greatly increased upon stimulation (Fig. 2B). Moreover, TBK1 bound to optineurin was activated, that is, phosphorylated on S172 (Fig. 2C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2016/09/20	2018/04/06	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	rigid:wwuKbyeoXJf+yXxZjKlMVRJ0GSk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K3K8	uniprotkb:Q9WUN2	intact:EBI-9683583|uniprotkb:A2ASP3|ensembl:ENSMUSP00000027986|ensembl:ENSMUSP00000110648	intact:EBI-764193|uniprotkb:Q9CT90|uniprotkb:Q9DC03|ensembl:ENSMUSP00000020316	psi-mi:optn_mouse(display_long)|uniprotkb:Optn(gene name)|psi-mi:Optn(display_short)	psi-mi:tbk1_mouse(display_long)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:Tbk1(gene name)|psi-mi:Tbk1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meena et al. (2016)	imex:IM-25518|pubmed:27086836	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-12521947|imex:IM-25518-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237289.1|refseq:NP_862896.1|refseq:XP_006497609.1|refseq:XP_006497610.1|ensembl:ENSMUSG00000026672(gene)|ensembl:ENSMUST00000027986(transcript)|ensembl:ENSMUST00000114996(transcript)|go:"GO:0001155"(TFIIIA-class transcription factor binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055037"(recycling endosome)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|rcsb pdb:5WQ4|reactome:R-MMU-2565942|reactome:R-MMU-8854214	refseq:NP_062760.3|dip:DIP-29880N|interpro:IPR041087|interpro:IPR041309|mint:Q9WUN2|rcsb pdb:4JL9|rcsb pdb:4JLC|rcsb pdb:6O8C|reactome:R-MMU-168928|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-9008059|reactome:R-MMU-936440|reactome:R-MMU-936964|ensembl:ENSMUSG00000020115(gene)|ensembl:ENSMUST00000020316(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdm)|taxid:10090(Mus musculus)	-	2016/09/20	2016/09/20	rogid:/u8Vz7hczv303Dfumtnus9SqFz810090	rogid:yuQ8W5zOu+0zBDNIy3E3Ox8375410090	rigid:J87Qvhqcx4NQWVrGpRCy+exWzmc	false	binding-associated region:1-157	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)