#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A0ZVR0	uniprotkb:Q68871	intact:EBI-12517858|uniprotkb:A2ICR8|uniprotkb:K7GN78	intact:EBI-12522528	psi-mi:a0zvr0_pig(display_long)|uniprotkb:Irf7(gene name)|psi-mi:Irf7(display_short)|uniprotkb:IRF7(gene name synonym)	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517841|imex:IM-25861-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001090897.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036388|interpro:IPR036390	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	-	-	-	figure legend:1A, 2 and 3F|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:84FjGjVIpXZWXlS6mjljSpDa7ZY9823	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rigid:LS1+tHmNCeCGhmiqW2HTu/wKVDU	false	-	mutation disrupting interaction strength:112-112|mutation decreasing interaction strength:69-69|mutation disrupting interaction strength:112-112|mutation disrupting interaction strength:134-134|mutation disrupting interaction strength:138-138|mutation disrupting interaction strength:161-161|mutation disrupting interaction strength:136-136|sufficient binding region:1-168	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68871	uniprotkb:Q764M6	intact:EBI-12522528	intact:EBI-12512266|ensembl:ENSSSCP00040008173	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:irf3_pig(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517896|imex:IM-25861-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	ensembl:ENSSSCG00040014662(gene)|ensembl:ENSSSCT00040019663(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|reactome:R-SSC-1169408|reactome:R-SSC-1606341|reactome:R-SSC-168928|reactome:R-SSC-3134973|reactome:R-SSC-3134975|reactome:R-SSC-3270619|reactome:R-SSC-9013973|reactome:R-SSC-918233|reactome:R-SSC-933541|reactome:R-SSC-936440|reactome:R-SSC-936964|refseq:NP_998935.1	-	-	-	figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:k8mIgjpiImgr8GDDQbkAz1SlbfI9823	rigid:Fb+lqCzCzPrzzf5jqzWHjzqHauA	false	sufficient binding region:1-168	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68871	uniprotkb:A0ZVR0	intact:EBI-12522528	intact:EBI-12517858|uniprotkb:A2ICR8|uniprotkb:K7GN78	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:a0zvr0_pig(display_long)|uniprotkb:Irf7(gene name)|psi-mi:Irf7(display_short)|uniprotkb:IRF7(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517896|imex:IM-25861-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001090897.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:84FjGjVIpXZWXlS6mjljSpDa7ZY9823	rigid:Fb+lqCzCzPrzzf5jqzWHjzqHauA	false	sufficient binding region:1-168	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68871	uniprotkb:A0ZVR0	intact:EBI-12522528	intact:EBI-12517858|uniprotkb:A2ICR8|uniprotkb:K7GN78	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:a0zvr0_pig(display_long)|uniprotkb:Irf7(gene name)|psi-mi:Irf7(display_short)|uniprotkb:IRF7(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517944|imex:IM-25861-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001090897.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:3F|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:84FjGjVIpXZWXlS6mjljSpDa7ZY9823	rigid:LS1+tHmNCeCGhmiqW2HTu/wKVDU	false	sufficient binding region:1-168	sufficient binding region:1-268	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68871	uniprotkb:Q764M6	intact:EBI-12522528	intact:EBI-12512266|ensembl:ENSSSCP00040008173	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:irf3_pig(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517951|imex:IM-25861-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	ensembl:ENSSSCG00040014662(gene)|ensembl:ENSSSCT00040019663(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|reactome:R-SSC-1169408|reactome:R-SSC-1606341|reactome:R-SSC-168928|reactome:R-SSC-3134973|reactome:R-SSC-3134975|reactome:R-SSC-3270619|reactome:R-SSC-9013973|reactome:R-SSC-918233|reactome:R-SSC-933541|reactome:R-SSC-936440|reactome:R-SSC-936964|refseq:NP_998935.1	-	-	-	figure legend:1,2 and 3E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:k8mIgjpiImgr8GDDQbkAz1SlbfI9823	rigid:qT0WPVZ4a2LQXnI0SMfRILNxc7I	false	mutation disrupting interaction strength:112-112|sufficient binding region:1-168	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68871	uniprotkb:A0ZVR0	intact:EBI-12522528	intact:EBI-12517858|uniprotkb:A2ICR8|uniprotkb:K7GN78	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:a0zvr0_pig(display_long)|uniprotkb:Irf7(gene name)|psi-mi:Irf7(display_short)|uniprotkb:IRF7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517928|imex:IM-25861-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001090897.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:84FjGjVIpXZWXlS6mjljSpDa7ZY9823	rigid:LS1+tHmNCeCGhmiqW2HTu/wKVDU	false	sufficient binding region:1-168	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q68871	uniprotkb:A0ZVR0	intact:EBI-12522528	intact:EBI-12517858|uniprotkb:A2ICR8|uniprotkb:K7GN78	psi-mi:q68871_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym)	psi-mi:a0zvr0_pig(display_long)|uniprotkb:Irf7(gene name)|psi-mi:Irf7(display_short)|uniprotkb:IRF7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fiebach et al. (2011)	pubmed:21680532|imex:IM-25861	taxid:358769(classical swine fever virus - alfort/187)|taxid:358769(classical swine fever virus - alfort/187)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-12517936|imex:IM-25861-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021824|interpro:IPR022120|interpro:IPR027417|interpro:IPR030399|interpro:IPR032521|interpro:IPR033130|rcsb pdb:4H9J|rcsb pdb:4H9K|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR036430|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001090897.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036388|interpro:IPR036390	-	-	-	figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/09/12	2016/09/21	rogid:Q5SceFsLg7z7DSoVZnGCx+9+kAI358769	rogid:84FjGjVIpXZWXlS6mjljSpDa7ZY9823	rigid:LS1+tHmNCeCGhmiqW2HTu/wKVDU	false	flag tag:n-n|sufficient binding region:1-168	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)