#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14793	uniprotkb:P09958	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-1056807|uniprotkb:Q14336|uniprotkb:Q6LBS3|uniprotkb:Q9UCZ5|ensembl:ENSP00000268171|ensembl:ENSP00000483552|ensembl:ENSP00000484952|ensembl:ENSP00000506143	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:furin_human(display_long)|uniprotkb:FURIN(gene name)|psi-mi:FURIN(display_short)|uniprotkb:FUR(gene name synonym)|uniprotkb:PACE(gene name synonym)|uniprotkb:PCSK3(gene name synonym)|uniprotkb:Paired basic amino acid residue-cleaving enzyme(gene name synonym)|uniprotkb:Dibasic-processing enzyme(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Szláma et al. (2015)	imex:IM-23834|pubmed:25543063	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10171267|imex:IM-23834-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_002560.1|refseq:NP_001276752.1|refseq:NP_001276753.1|go:"GO:0097341"(zymogen inhibition)|go:"GO:1901394"(positive regulation of transforming growth factor beta1 activation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR002884(Proprotein convertase, P)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR032815|interpro:IPR034182|interpro:IPR036852|interpro:IPR038466|mint:P09958|rcsb pdb:4OMC|rcsb pdb:4OMD|rcsb pdb:4RYD|rcsb pdb:4Z2A|rcsb pdb:5JMO|rcsb pdb:5JXG|rcsb pdb:5JXH|rcsb pdb:5JXI|rcsb pdb:5JXJ|rcsb pdb:5MIM|rcsb pdb:6A8Y|rcsb pdb:6EQV|rcsb pdb:6EQW|rcsb pdb:6EQX|rcsb pdb:6HLB|rcsb pdb:6HLD|rcsb pdb:6HLE|rcsb pdb:6HZA|rcsb pdb:6HZB|rcsb pdb:6HZC|rcsb pdb:6HZD|rcsb pdb:6YD2|rcsb pdb:6YD3|rcsb pdb:6YD4|rcsb pdb:6YD7|reactome:R-HSA-1181150|reactome:R-HSA-1442490|reactome:R-HSA-1566948|reactome:R-HSA-1592389|go:"GO:0090472"(dibasic protein processing)|reactome:R-HSA-159782|reactome:R-HSA-167060|reactome:R-HSA-171286|reactome:R-HSA-186797|reactome:R-HSA-1912420|reactome:R-HSA-2173789|reactome:R-HSA-5210891|reactome:R-HSA-6809371|reactome:R-HSA-8963889|reactome:R-HSA-9662834|reactome:R-HSA-9679191|reactome:R-HSA-9694614|reactome:R-HSA-977225|ensembl:ENSG00000140564(gene)|ensembl:ENST00000268171(transcript)|ensembl:ENST00000610579(transcript)|ensembl:ENST00000618099(transcript)|ensembl:ENST00000680053(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002020"(protease binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0019058"(viral life cycle)|go:"GO:0019082"(viral protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031638"(zymogen activation)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032902"(nerve growth factor production)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032940"(secretion by cell)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051004"(regulation of lipoprotein lipase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|dip:DIP-29904N	-	comment:mint|comment:homomint	-	figure legend:f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/13	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:fARxF82aRgmZAfcuuw1QgDBKjCU9606	intact-crc:3048B1B26A5A6CCE|rigid:S7A3CDiTPX1kzidombTx3GYYo2Q	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14793	uniprotkb:P13497	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Szláma et al. (2015)	imex:IM-23834|pubmed:25543063	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10171271|imex:IM-23834-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	-	comment:mint|comment:homomint	-	figure legend:f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/13	2015/02/13	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	intact-crc:A06D07FF25EEED98|rigid:E97/62u9FgRbwdDYyRd9FkXPKNA	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)