#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97477	uniprotkb:P04198	intact:EBI-6895349|ensembl:ENSMUSP00000104767|ensembl:ENSMUSP00000104768|uniprotkb:O35624|uniprotkb:Q8C3H8|uniprotkb:Q91YU4	intact:EBI-878369|ensembl:ENSP00000281043|uniprotkb:Q6LDT9|uniprotkb:Q53XS5	psi-mi:aurka_mouse(display_long)|uniprotkb:Serine/threonine-protein kinase Ayk1(gene name synonym)|uniprotkb:Aurka(gene name)|psi-mi:Aurka(display_short)|uniprotkb:Aik(gene name synonym)|uniprotkb:Airk(gene name synonym)|uniprotkb:Ark1(gene name synonym)|uniprotkb:Aura(gene name synonym)|uniprotkb:Ayk1(gene name synonym)|uniprotkb:Btak(gene name synonym)|uniprotkb:Iak1(gene name synonym)|uniprotkb:Stk15(gene name synonym)|uniprotkb:Stk6(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Aurora family kinase 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Ipl1- and aurora-related kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:mycn_human(display_long)|uniprotkb:MYCN(gene name)|psi-mi:MYCN(display_short)|uniprotkb:NMYC(gene name synonym)|uniprotkb:BHLHE37(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 37(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Hill et al. (2015)	imex:IM-24167|pubmed:25533335	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10821352|imex:IM-24167-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278114.1|ensembl:ENSMUSG00000027496(gene)|ensembl:ENSMUST00000109139(transcript)|ensembl:ENSMUST00000109140(transcript)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|rcsb pdb:3D14|rcsb pdb:3D15|rcsb pdb:3D2I|rcsb pdb:3D2K|rcsb pdb:3DAJ|rcsb pdb:3DJ5|rcsb pdb:3DJ6|interpro:IPR000719(Protein kinase, core)|rcsb pdb:3DJ7|reactome:R-MMU-174178|reactome:R-MMU-2565942|reactome:R-MMU-6804114|reactome:R-MMU-6804756|reactome:R-MMU-8854050|reactome:R-MMU-8854518|reactome:R-MMU-8854521|go:"GO:0045120"(pronucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1990138"(neuron projection extension)|refseq:XP_006499138.1|refseq:NP_035627.1	go:"GO:0010942"(positive regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|ensembl:ENSG00000134323(gene)|ensembl:ENST00000281043(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:NP_001280157.1|refseq:NP_001280160.1|refseq:NP_001280162.1|refseq:NP_005369.2|refseq:XP_016859657.1|dip:DIP-36822N|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638|mint:P04198|rcsb pdb:5G1X	-	-	-	figure legend:4A|antagonist:"MLN8237 (Alisertib)- a small molecule specific Aurora A kinase inhibitor."|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-medulloblastoma)|taxid:10090(Mouse medulloblastoma)	-	2015/04/27	2015/05/19	rogid:M5MqE2aYlampBYmApX8pA6ut8+A10090	rogid:g0tHS7YZaw+3cZLL//kUF2opQJc9606	rigid:Ejosvvi8nmNkXWN+TsoLLKMLZ1M	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)