#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60591	intact:EBI-11413485	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	-	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:cns9c_enhancer_il10_gene_probe(display_short)|psi-mi:EBI-11413485(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413483|imex:IM-24716-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	-	figure legend:2C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/01	2015/11/11	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O88942	intact:EBI-11413485	intact:EBI-8073353|uniprotkb:O70345|intact:MINT-6612506	-	psi-mi:nfac1_mouse(display_long)|uniprotkb:Nfatc1(gene name)|psi-mi:Nfatc1(display_short)|uniprotkb:Nfat2(gene name synonym)|uniprotkb:Nfatc(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym)	psi-mi:cns9c_enhancer_il10_gene_probe(display_short)|psi-mi:EBI-11413485(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413495|imex:IM-24716-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	interpro:IPR032397|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR011539(Rel homology)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR037059|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002337"(B-1a B cell differentiation)|go:"GO:0003170"(heart valve development)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000647"(negative regulation of stem cell proliferation)|go:"GO:0014883"(transition between fast and slow fiber)|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763	-	-	comment:mint|function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells	-	figure legend:2C-2|causality statement:"CHEBI:63954 and CHEBI:37537 increase the expression at RNA level of  ENSMUSG00000016529"|causality statement:O88942 and Q60591 increase the expression at RNA level of ENSMUSG00000016529|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/01	2015/11/11	rogid:jZN9fTzBdPNHxfb7e6nFy1AGnd410090	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q64287	intact:EBI-11413509	intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802	-	psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym)	psi-mi:cns9a_enhancer_il10_gene_probe(display_short)|psi-mi:EBI-11413509(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413501|imex:IM-24716-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N	-	-	-	-	figure legend:2D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/01	2015/11/11	rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
ensembl:ENSMUSG00000055170	uniprotkb:Q60591	intact:EBI-11174470	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)|ensembl:ifng_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000055170(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413519|imex:IM-24716-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_032363.1	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:2E|comment:positive control|causality statement:"CHEBI:63954 and CHEBI:37537 increase the expression at RNA level of  ENSMUSG00000055170"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_th1)|taxid:10090(Mouse T helper cell Th1)	-	2015/10/01	2015/11/11	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000016529	uniprotkb:Q60591	intact:EBI-6398833	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:il10_mouse_gene(display_short)|psi-mi:ENSMUSG00000016529(display_long)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413547|imex:IM-24716-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	-	-	-	figure legend:2E|causality statement:"CHEBI:63954 and CHEBI:37537 increase the expression at RNA level of  ENSMUSG00000016529"|causality statement:"CHEBI:4031  decreases  the expression at RNA level of  ENSMUSG00000016529"|causality statement:Q60591 increases  the expression at RNA level of  ENSMUSG00000016529|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2)	-	2015/10/01	2015/11/11	-	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q60591	ensembl:ENSMUSG00000000869	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	intact:EBI-11413561	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	uniprotkb:Il4(gene name)|psi-mi:Il4(display_short)|uniprotkb:Il-4(gene name synonym)|ensembl:il4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000000869(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413555|imex:IM-24716-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	refseq:NP_067258.1	-	-	-	figure legend:2E-2|comment:positive control|causality statement:"CHEBI:63954 and CHEBI:37537 increase the expression at RNA level of ENSMUSG00000000869"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2)	-	2015/10/01	2015/11/11	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000016529	uniprotkb:Q64287	intact:EBI-6398833	intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802	psi-mi:il10_mouse_gene(display_short)|psi-mi:ENSMUSG00000016529(display_long)	psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413570|imex:IM-24716-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N	-	-	-	figure legend:2Ei|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2)	-	2015/10/01	2015/11/11	-	rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q64287	ensembl:ENSMUSG00000000869	intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802	intact:EBI-11413561	psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym)	uniprotkb:Il4(gene name)|psi-mi:Il4(display_short)|uniprotkb:Il-4(gene name synonym)|ensembl:il4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000000869(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lee et al. (2009)	pubmed:18962896|imex:IM-24716	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11413576|imex:IM-24716-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N	refseq:NP_067258.1	-	-	-	figure legend:2E-2i|comment:weak interaction|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2)	-	2015/10/01	2015/11/11	rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)