#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:8925"	uniprotkb:Q9TS33	intact:EBI-6857858	intact:EBI-9542578	psi-mi:ryanodine(display_short)|psi-mi:"CHEBI:8925"(display_long)	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Liu et al. (2001)	imex:IM-22912|pubmed:11353864	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9551646|imex:IM-22912-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	-	-	-	figure legend:Fig. 2|agonist:0.8 mM Ca 2+|agonist:2.5 mM caffeine|antagonist:5 mM Mg 2+|kinetics:Bmax=413 pmol/mg|kd:1.9 nM|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.9x10^-9(molar)	2014/05/30	2014/10/16	-	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	intact-crc:F2935830051A7A0B	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:8925"	uniprotkb:Q9TS33	intact:EBI-6857858	intact:EBI-9542578	psi-mi:ryanodine(display_short)|psi-mi:"CHEBI:8925"(display_long)	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Liu et al. (2001)	imex:IM-22912|pubmed:11353864	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9551644|imex:IM-22912-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	-	-	-	figure legend:Fig. 2|agonist:0.8 mM Ca 2+|agonist:2.5 mM caffeine|antagonist:5 mM Mg2+|kinetics:Bmax=447 pmol/mg|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.6x10^-9(molar)	2014/05/30	2014/10/16	-	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	intact-crc:834AD60777766F8A	false	3h radiolabel:?-?	glutathione s tranferase tag:n-n|myc tag:4318-4319	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9TS33	uniprotkb:Q9TS33	intact:EBI-9542578	intact:EBI-9542578	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Liu et al. (2001)	imex:IM-22912|pubmed:11353864	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9542616|imex:IM-22912-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	-	-	-	figure legend:Fig. 3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/30	2014/10/16	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	intact-crc:B5B028033392621E|rigid:dtNEdcb/xJgKIGAyHbnSDgna8PA	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9TS33	uniprotkb:Q9TS33	intact:EBI-9542578	intact:EBI-9542578	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:ryr3_rabit(display_long)|uniprotkb:Brain ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Brain-type ryanodine receptor(gene name synonym)|uniprotkb:Type 3 ryanodine receptor(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Liu et al. (2001)	imex:IM-22912|pubmed:11353864	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9542620|imex:IM-22912-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|refseq:NP_001076231.1|interpro:IPR035761|interpro:IPR035762|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)	-	-	-	figure legend:Fig. 3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/30	2014/10/16	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	rogid:jMlezkDLDmUuAe5SG5aUrP9sWOU9986	intact-crc:AE7E51B1808068C3|rigid:dtNEdcb/xJgKIGAyHbnSDgna8PA	false	glutathione s tranferase tag:n-n|myc tag:4318-4319	glutathione s tranferase tag:n-n|myc tag:4318-4319	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)