#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6IAA8	uniprotkb:P42345	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394692|imex:IM-18114-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Fig. 3A|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:CD6316DA381B9E93|rigid:GBSNmSyLqiXIdunzDsQUbZcvzec	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q8N122	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394692|imex:IM-18114-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 3A|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:CD6316DA381B9E93|rigid:GBSNmSyLqiXIdunzDsQUbZcvzec	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q8N122	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394707|imex:IM-18114-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 3B|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:48498EDBED1638B6|rigid:13BkKzxoDIFV424B9KLGz2+rHW8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:P42345	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394707|imex:IM-18114-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Fig. 3B|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:48498EDBED1638B6|rigid:13BkKzxoDIFV424B9KLGz2+rHW8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:P42345	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394684|imex:IM-18114-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Fig. 3A|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:A9FAFCF98E916BDD|rigid:5T7kYurlfOMdMeVtJ3FUAhMxdTg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q8N122	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394684|imex:IM-18114-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 3A|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:A9FAFCF98E916BDD|rigid:5T7kYurlfOMdMeVtJ3FUAhMxdTg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:P42345	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394715|imex:IM-18114-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	-	-	-	figure legend:Supp. Fig. 3B|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	intact-crc:FC29763345DB601F|rigid:co5EuWpkEC72l2gfBOSCbZjx0OI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q8N122	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394715|imex:IM-18114-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 3B|agonist:Amino acid stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:FC29763345DB601F|rigid:co5EuWpkEC72l2gfBOSCbZjx0OI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q9UHA4	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394746|imex:IM-18114-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 4E, Supp. Fig. 4E|comment:"The heterodimer of nucleotide-free RagB and wild-type RagC (RagB Thr54Asn-RagC) interacted with Ragulator at levels 4- to 6-fold greater than the heterodimer of wild-type RagB and nucleotide-free RagC (RagB-RagC Ser75Asn)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:7430360287CA6D8B|rigid:xrHaMuJQ3+tc+csuoo7MQo5uRjc	false	flag tag:?-?|mutation increasing interaction strength:54-54	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q9HB90	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394746|imex:IM-18114-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4E, Supp. Fig. 4E|comment:"The heterodimer of nucleotide-free RagB and wild-type RagC (RagB Thr54Asn-RagC) interacted with Ragulator at levels 4- to 6-fold greater than the heterodimer of wild-type RagB and nucleotide-free RagC (RagB-RagC Ser75Asn)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:7430360287CA6D8B|rigid:xrHaMuJQ3+tc+csuoo7MQo5uRjc	false	flag tag:?-?|mutation increasing interaction strength:54-54	ha tag:?-?|glutathione s tranferase tag:?-?|mutation increasing interaction strength:75-75	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q6IAA8	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394746|imex:IM-18114-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 4E, Supp. Fig. 4E|comment:"The heterodimer of nucleotide-free RagB and wild-type RagC (RagB Thr54Asn-RagC) interacted with Ragulator at levels 4- to 6-fold greater than the heterodimer of wild-type RagB and nucleotide-free RagC (RagB-RagC Ser75Asn)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:7430360287CA6D8B|rigid:xrHaMuJQ3+tc+csuoo7MQo5uRjc	false	flag tag:?-?|mutation increasing interaction strength:54-54	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q9UHA4	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393902|imex:IM-18114-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:5A8135510373E5DD|rigid:+kA1xV/CipZniGvi3rsGybV9tQk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q9HB90	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393902|imex:IM-18114-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:5A8135510373E5DD|rigid:+kA1xV/CipZniGvi3rsGybV9tQk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q7L523	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393902|imex:IM-18114-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:5A8135510373E5DD|rigid:+kA1xV/CipZniGvi3rsGybV9tQk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q6IAA8	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393902|imex:IM-18114-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:5A8135510373E5DD|rigid:+kA1xV/CipZniGvi3rsGybV9tQk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393893|imex:IM-18114-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:8A30E8136A0C65EA|rigid:GNlj0JEUXjLEzXfMH0QHedQ6n9o	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q7L523	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393893|imex:IM-18114-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:8A30E8136A0C65EA|rigid:GNlj0JEUXjLEzXfMH0QHedQ6n9o	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9UHA4	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393893|imex:IM-18114-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:8A30E8136A0C65EA|rigid:GNlj0JEUXjLEzXfMH0QHedQ6n9o	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9HB90	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393893|imex:IM-18114-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1A, 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:8A30E8136A0C65EA|rigid:GNlj0JEUXjLEzXfMH0QHedQ6n9o	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q9UHA4	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6395834|imex:IM-18114-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig.  6A|comment:"The heterodimer of nucleotide-free RagB and wild-type RagC (RagB Thr54Asn-RagC) interacted with Ragulator at levels 4- to 6-fold greater than the heterodimer of wild-type RagB and nucleotide-free RagC (RagB-RagC Ser75Asn)"|comment:"v-ATPase inhibitor Salicylihalamide A (SalA) prevented amino acid stimulation from weakening the Rag-Ragulator interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:C5D28DB3AC9235B7|rigid:GwyfO1uz7tYz8VtcpvzJ19RLH1I	false	flag tag:?-?|mutation decreasing interaction strength:99-99	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q6IAA8	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6395834|imex:IM-18114-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig.  6A|comment:"The heterodimer of nucleotide-free RagB and wild-type RagC (RagB Thr54Asn-RagC) interacted with Ragulator at levels 4- to 6-fold greater than the heterodimer of wild-type RagB and nucleotide-free RagC (RagB-RagC Ser75Asn)"|comment:"v-ATPase inhibitor Salicylihalamide A (SalA) prevented amino acid stimulation from weakening the Rag-Ragulator interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:C5D28DB3AC9235B7|rigid:GwyfO1uz7tYz8VtcpvzJ19RLH1I	false	flag tag:?-?|mutation decreasing interaction strength:99-99	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q6IAA8	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393884|imex:IM-18114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:DF1D767E492C7E64|rigid:dRCXK/qj0JaZJTD3EiOIPsYKKXg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q9UHA4	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393884|imex:IM-18114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:DF1D767E492C7E64|rigid:dRCXK/qj0JaZJTD3EiOIPsYKKXg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q9HB90	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393884|imex:IM-18114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:DF1D767E492C7E64|rigid:dRCXK/qj0JaZJTD3EiOIPsYKKXg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q7L523	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393884|imex:IM-18114-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:DF1D767E492C7E64|rigid:dRCXK/qj0JaZJTD3EiOIPsYKKXg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9Y2Q5	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394651|imex:IM-18114-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 3C, 4A|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:59953696F8781900|rigid:YF7dmSekAsppSOSg1Av2gPhkymM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9UHA4	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394651|imex:IM-18114-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 3C, 4A|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:59953696F8781900|rigid:YF7dmSekAsppSOSg1Av2gPhkymM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:O43504	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394651|imex:IM-18114-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 3C, 4A|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:59953696F8781900|rigid:YF7dmSekAsppSOSg1Av2gPhkymM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q6IAA8	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394651|imex:IM-18114-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 3C, 4A|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:59953696F8781900|rigid:YF7dmSekAsppSOSg1Av2gPhkymM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q7L523	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394600|imex:IM-18114-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3B|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:5B2D6E7BE0E7497A|rigid:SZXAGhWSbVuZ3Fs0Gc+9IFdKMc8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43504	uniprotkb:Q9HB90	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394600|imex:IM-18114-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3B|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:5B2D6E7BE0E7497A|rigid:SZXAGhWSbVuZ3Fs0Gc+9IFdKMc8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q7L523	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394807|imex:IM-18114-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 5F|comment:LAMTOR1, LAMTOR3, HBXIP, C7orf59 were also present in the assay but not identified within the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:CA38ACC4FDAEA784|rigid:HFL8Qyxx3A2wgjrpEDgl/A2zVpk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9HB90	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394807|imex:IM-18114-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 5F|comment:LAMTOR1, LAMTOR3, HBXIP, C7orf59 were also present in the assay but not identified within the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:CA38ACC4FDAEA784|rigid:HFL8Qyxx3A2wgjrpEDgl/A2zVpk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9HB90	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394506|imex:IM-18114-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3A|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:5A4ADE67F6BC482F|rigid:HFL8Qyxx3A2wgjrpEDgl/A2zVpk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q7L523	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394506|imex:IM-18114-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3A|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:5A4ADE67F6BC482F|rigid:HFL8Qyxx3A2wgjrpEDgl/A2zVpk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q7L523	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394641|imex:IM-18114-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3B|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:278FACC00108BBE4|rigid:TmH93EyDED+P6Vp1AwY6nkEmipI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0VGL1	uniprotkb:Q9HB90	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394641|imex:IM-18114-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3B|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:278FACC00108BBE4|rigid:TmH93EyDED+P6Vp1AwY6nkEmipI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q0VGL1	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:O43504	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394527|imex:IM-18114-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 4B, Supp. Fig. 3C|agonist:Amino acid starvation|agonist:EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:1078C558024C5CC9|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6395914|imex:IM-18114-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3D, 6B, Supp. Fig. 6A|agonist:Amino acid starvation|comment:"v-ATPase inhibitor Salicylihalamide A (SalA)  or Concanamycin A (ConA) prevented amino acid stimulation from weakening the Rag-Ragulator interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:1F5C68C6368D9B98|rigid:PXpH8FpqUG9gBTm0GdvvSmlfk9c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6395914|imex:IM-18114-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3D, 6B, Supp. Fig. 6A|agonist:Amino acid starvation|comment:"v-ATPase inhibitor Salicylihalamide A (SalA)  or Concanamycin A (ConA) prevented amino acid stimulation from weakening the Rag-Ragulator interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:1F5C68C6368D9B98|rigid:PXpH8FpqUG9gBTm0GdvvSmlfk9c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552032|imex:IM-18114-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3A|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:526FC8A79FAFB09F|rigid:PXpH8FpqUG9gBTm0GdvvSmlfk9c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6552032|imex:IM-18114-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3A|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:526FC8A79FAFB09F|rigid:PXpH8FpqUG9gBTm0GdvvSmlfk9c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394675|imex:IM-18114-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3D|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:594FA23FA9595627|rigid:zSxc2KraYy5CsXiBfYaiZkMbbSg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:P21281	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394675|imex:IM-18114-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Fig. 3D|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:594FA23FA9595627|rigid:zSxc2KraYy5CsXiBfYaiZkMbbSg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394675|imex:IM-18114-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3D|agonist:Amino acid starvation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:594FA23FA9595627|rigid:zSxc2KraYy5CsXiBfYaiZkMbbSg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHA4	uniprotkb:Q9Y2Q5	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394430|imex:IM-18114-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 1G|comment:Trace amounts of RRAGB and RRAGC were also present in this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:1FA866E2E3B7EBA5|rigid:xPTMIKSjZt9C0HQGdJussmtrBVM	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9UHA4	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9HB90	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q0VGL1	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:O43504	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q5VZM2-2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-6395842|ensembl:ENSP00000364077	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394282|imex:IM-18114-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	-	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	intact-crc:CB9B91CD1B11196C|rigid:ks6AGWFVE1KkdTkAAnKs9+uzx7o	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393965|imex:IM-18114-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Supp. Fig. 1C|comment:Presence of ancillary molecules in the complex inferred from lack of bait/prey interaction in their absence.  RagB also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:23E3336A0F128202|rigid:yV7Js2L0mDi6d1j2Azeujv1ee6I	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393965|imex:IM-18114-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Supp. Fig. 1C|comment:Presence of ancillary molecules in the complex inferred from lack of bait/prey interaction in their absence.  RagB also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:23E3336A0F128202|rigid:yV7Js2L0mDi6d1j2Azeujv1ee6I	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HB90	uniprotkb:Q9Y2Q5	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393965|imex:IM-18114-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Supp. Fig. 1C|comment:Presence of ancillary molecules in the complex inferred from lack of bait/prey interaction in their absence.  RagB also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:23E3336A0F128202|rigid:yV7Js2L0mDi6d1j2Azeujv1ee6I	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HB90	uniprotkb:O43504	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393965|imex:IM-18114-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Supp. Fig. 1C|comment:Presence of ancillary molecules in the complex inferred from lack of bait/prey interaction in their absence.  RagB also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:23E3336A0F128202|rigid:yV7Js2L0mDi6d1j2Azeujv1ee6I	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HB90	uniprotkb:Q0VGL1	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393965|imex:IM-18114-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Supp. Fig. 1C|comment:Presence of ancillary molecules in the complex inferred from lack of bait/prey interaction in their absence.  RagB also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:23E3336A0F128202|rigid:yV7Js2L0mDi6d1j2Azeujv1ee6I	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394231|imex:IM-18114-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:3ADEC2BE6BEC25D9|rigid:vMIZ2Qg4+Vfr7SZWSuUhfaAvyL8	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394441|imex:IM-18114-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1H|comment:LAMTOR3, HBXIP, C7orf59 and RRAGC were also present in the assay but not shown to be present in the pulldown.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:F04F41FC7FD65730|rigid:XHC8n5YkjQ08zDZ25dUovFkoCk0	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q5VZM2-2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-6395842|ensembl:ENSP00000364077	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394441|imex:IM-18114-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	-	-	-	figure legend:Fig. 1H|comment:LAMTOR3, HBXIP, C7orf59 and RRAGC were also present in the assay but not shown to be present in the pulldown.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	intact-crc:F04F41FC7FD65730|rigid:XHC8n5YkjQ08zDZ25dUovFkoCk0	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394206|imex:IM-18114-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:A06083507C28E25C|rigid:vMIZ2Qg4+Vfr7SZWSuUhfaAvyL8	false	flag tag:?-?	ha tag:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5VZM2-2	uniprotkb:Q9Y2Q5	intact:EBI-6395842|ensembl:ENSP00000364077	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:q5vzm2-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394795|imex:IM-18114-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000374941(transcript)|intact:EBI-993049(isoform-parent)|uniprotkb:Q5VZM2-2(isoform-parent)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:4C and Supp. Fig. 4B|comment:LAMTOR3, HBXIP, C7orf59 and RRAGC were also present in the assay but not shown to be present in the pulldown.|antagonist:GTP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:GW8xVq9aywGP/77c3MAaXWLCx/09606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:9A7112CE2AD30C66|rigid:IajpD+DrCd9UNbQGHCD7SeZjS28	false	flag tag:?-?	ha tag:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:O43504	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394166|imex:IM-18114-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:C4733FD0C129BBF1|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394166|imex:IM-18114-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:C4733FD0C129BBF1|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q0VGL1	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394166|imex:IM-18114-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:C4733FD0C129BBF1|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394259|imex:IM-18114-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the  complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:99B3621B34BE55A5|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q9Y2Q5	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394259|imex:IM-18114-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the  complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:99B3621B34BE55A5|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q6IAA8	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394259|imex:IM-18114-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1E|comment:LAMTOR3/MP1 also present in the assay mix but not shown to be present in the  complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:99B3621B34BE55A5|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q0VGL1	uniprotkb:O43504	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394190|imex:IM-18114-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 1E|comment:MP1 also present in assay mix but not demonstrated to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:1F9E0355E1656763|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q0VGL1	uniprotkb:Q6IAA8	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394190|imex:IM-18114-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1E|comment:MP1 also present in assay mix but not demonstrated to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:1F9E0355E1656763|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q0VGL1	uniprotkb:Q9Y2Q5	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6394190|imex:IM-18114-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 1E|comment:MP1 also present in assay mix but not demonstrated to be present in the complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:1F9E0355E1656763|rigid:KxCpXzqTAy/ErfqX7bNMdhgGaPg	false	ha tag:?-?|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43504	uniprotkb:Q6IAA8	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393942|imex:IM-18114-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:4C99CCEFAD855FD1|rigid:E9j3x49acO+ON5fp0fR+ni4rwQM	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q0VGL1	uniprotkb:Q6IAA8	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393936|imex:IM-18114-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:CB4EFF95CC7DFA6B|rigid:SRuZ+ltMNCws1motKVuflQHpzb0	false	flag tag:?-?	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q6IAA8	uniprotkb:Q0VGL1	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:O43504	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bar-Peled et al. (2012)	pubmed:22980980|imex:IM-18114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6393917|imex:IM-18114-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/11/19	2014/10/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:F53B484949B9BB8E|rigid:TIrf3wIkn/UbrYfI0gL0wcWLTpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)