#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H461	uniprotkb:P98086	intact:EBI-6254212|ensembl:ENSP00000363826	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6171722|imex:IM-17380-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	intact-crc:3700E07837F50018|rigid:KD1sfDj0A6KoKlWtBkYs/EQO5Hs	false	sufficient binding region:25-172|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98086	uniprotkb:Q9UP38	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	intact:EBI-6254383|ensembl:ENSP00000287934|uniprotkb:A4D1E8|uniprotkb:O94815|uniprotkb:Q549T8	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:fzd1_human(display_long)|uniprotkb:FZD1(gene name)|psi-mi:FZD1(display_short)|uniprotkb:FzE1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254434|imex:IM-17380-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	ensembl:ENSG00000157240(gene)|ensembl:ENST00000287934(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042493"|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0099054"(presynapse assembly)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086400|reactome:R-HSA-4641262|reactome:R-HSA-4608870|refseq:NP_003496.1	-	-	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	rogid:3QuP2xegWGasf4Z2/fCwFsQp4Uc9606	intact-crc:2F8BE190DB4D88F4|rigid:gATQNfxCkuc4d7LqQwFdmK7GBZE	false	-	myc tag:?-?|sufficient binding region:73..73-322..322|his tag:?-?|alkaline phosphatase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98086	uniprotkb:O75084	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	intact:EBI-746917|uniprotkb:Q53S59|uniprotkb:O94816|uniprotkb:Q96B74|ensembl:ENSP00000286201	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:fzd7_human(display_long)|uniprotkb:FzE3(gene name synonym)|uniprotkb:FZD7(gene name)|psi-mi:FZD7(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254564|imex:IM-17380-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	refseq:NP_003498.1|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-9673324|ensembl:ENSG00000155760(gene)|ensembl:ENST00000286201(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042666"(negative regulation of ectodermal cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026552|interpro:IPR036790|interpro:IPR042742|mint:O75084|rcsb pdb:4Z33|rcsb pdb:5T44|rcsb pdb:5URV|rcsb pdb:5WBS|rcsb pdb:6NE2|rcsb pdb:6NE4|rcsb pdb:6O3A|rcsb pdb:6O3B|reactome:R-HSA-373080	-	-	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	rogid:jvopJlAyREkQnaICXFPbufHIv5E9606	intact-crc:56D9540EFF6F7ED0|rigid:u9zEU1ic6mNT7zhcnX39grZwQeI	false	-	sufficient binding region:33..33-574..574	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98086	uniprotkb:Q9H461	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	intact:EBI-6254212|ensembl:ENSP00000363826	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6171749|imex:IM-17380-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	-	-	-	figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	intact-crc:EDED9A547F642F6E|rigid:KD1sfDj0A6KoKlWtBkYs/EQO5Hs	false	-	fc-igg tag:c-c|sufficient binding region:25-172	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98086	uniprotkb:Q14332	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254509|imex:IM-17380-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	-	-	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	intact-crc:CC90EBBEFD2BCA8A|rigid:v5e22PlkWbAxNXLun2i+qno/9Lc	false	-	his tag:?-?|myc tag:?-?|alkaline phosphatase tag:?-?|sufficient binding region:24..24-565..565	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H461	uniprotkb:P98086	intact:EBI-6254212|ensembl:ENSP00000363826	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254263|imex:IM-17380-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	-	-	-	figure legend:Fig. 1G, Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	intact-crc:06416EE80038AE1C|rigid:KD1sfDj0A6KoKlWtBkYs/EQO5Hs	false	alkaline phosphatase tag:?-?|sufficient binding region:28..28-275|his tag:?-?|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98086	uniprotkb:Q9ULV1	intact:EBI-299840|ensembl:ENSMUSP00000048836|intact:EBI-6171723|uniprotkb:Q9DCM6	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:c1qa_mouse(display_long)|uniprotkb:C1qa(gene name)|psi-mi:C1qa(display_short)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254550|imex:IM-17380-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036887(gene)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|ensembl:ENSMUST00000046285(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR037572|mint:P98086|reactome:R-MMU-166663|reactome:R-MMU-173623|reactome:R-MMU-977606|refseq:NP_031598.2	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	-	-	-	figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/02	2014/10/16	rogid:QjjOX9mLtiqcbgHsEOww/qvEdH410090	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	intact-crc:782B471F2F1C7642|rigid:Z2VI30QP/3Lfdpmsn3JRjemNDrk	false	-	his tag:?-?|alkaline phosphatase tag:?-?|myc tag:?-?|sufficient binding region:37..37-537..537	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-22195732	uniprotkb:Q9H461	-	intact:EBI-6254212|ensembl:ENSP00000363826	psi-mi:c1q_mouse(display_short)|psi-mi:EBI-22195732(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1qa:6xC1qb:6xC1qc"(complex systematic name)	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254284|imex:IM-17380-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|complex portal:CPX-1919(inferred-from)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|complex portal:CPX-4981(complex-primary)|go:"GO:0062167"(complement component C1q complex)|pubmed:26489954(see-also)|evidence ontology:"ECO:0005544"	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	-	complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain Each of the six heterotrimeric globular heads or domains, is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks, which appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand. Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-4984), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:Fig. 1H, 1I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-9(molar)	2012/07/02	2019/11/13	-	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	intact-crc:9B41C3A43A57B068	false	-	sufficient binding region:25-172|fc-igg tag:c-c	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q9H461	uniprotkb:P56704	intact:EBI-6254212|ensembl:ENSP00000363826	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254367|imex:IM-17380-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Supp. Fig. 1D, 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.25x10^-9(molar)	2012/07/02	2014/10/16	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	intact-crc:00170C5132799EE1|rigid:CIegS2/UYZCh3vb3XVEv43RM2BI	false	fc-igg tag:c-c|sufficient binding region:25-172	sufficient binding region:19-352	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q9H461	intact:EBI-22195732	intact:EBI-6254212|ensembl:ENSP00000363826	-	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:c1q_mouse(display_short)|psi-mi:EBI-22195732(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1qa:6xC1qb:6xC1qc"(complex systematic name)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254601|imex:IM-17380-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	go:"GO:0005509"(calcium ion binding)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|complex portal:CPX-1919(inferred-from)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|complex portal:CPX-4981(complex-primary)|go:"GO:0062167"(complement component C1q complex)|pubmed:26489954(see-also)|evidence ontology:"ECO:0005544"	-	-	complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain Each of the six heterotrimeric globular heads or domains, is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks, which appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand. Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-4984), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:Supp. Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.25x10^-9(molar)	2012/07/02	2019/11/13	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	-	intact-crc:14DC4792170EF36D	false	sufficient binding region:25-172|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q9H461	uniprotkb:P56704	intact:EBI-6254212|ensembl:ENSP00000363826	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0096"(pull down)	Naito et al. (2012)	imex:IM-17380|pubmed:22682250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254601|imex:IM-17380-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Supp. Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.25x10^-9(molar)	2012/07/02	2019/11/13	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	intact-crc:14DC4792170EF36D	false	sufficient binding region:25-172|fc-igg tag:c-c	sufficient binding region:19-352	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)