#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15085-2	uniprotkb:Q8BPM0	intact:EBI-6169263|ensembl:ENSP00000357177	intact:EBI-772938|uniprotkb:Q6DFY0|uniprotkb:Q3UHB4|uniprotkb:Q6TAB8|uniprotkb:Q80Y68|uniprotkb:Q9CQQ2|ensembl:ENSMUSP00000082406|ensembl:ENSMUSP00000152564	psi-mi:o15085-2(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:daam1_mouse(display_long)|uniprotkb:Daam1(gene name)|psi-mi:Daam1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169258|imex:IM-17372-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132694(gene)|ensembl:ENST00000368194(transcript)|intact:EBI-311099(isoform-parent)	refseq:NP_001273381.1|refseq:NP_080378.2|refseq:NP_766052.2|refseq:XP_006515705.1|refseq:XP_006515706.1|refseq:XP_006515707.1|ensembl:ENSMUSG00000034574(gene)|ensembl:ENSMUST00000085299(transcript)|ensembl:ENSMUST00000223272(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|reactome:R-MMU-4086400|reactome:R-MMU-5663220|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5C, 5F, 5G, Supp. Fig. 5|comment:"The interaction of DAAM1 and ARHGEF11 was greatly reduced in cells expressing Xdd1. The binding between DAAM1 and ARHGEF11 also decreased with depletion of either Dishevelled-2 or -3 and was almost undetectable after depletion of both (Figure 5G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/06/25	2014/10/16	rogid:wVKtYF1CBi2ImDIOS6YMmeNTBEY9606	rogid:cW/LGF6WMtPvGm1WnLA6SCN1Iqg10090	intact-crc:482FAD63C7C1ECC8|rigid:SEzeG5eiAEsrpMWygMAQdL41sRI	false	flag tag:?-?	sufficient binding region:421-1077|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BPM0	uniprotkb:O15085-2	intact:EBI-772938|uniprotkb:Q6DFY0|uniprotkb:Q3UHB4|uniprotkb:Q6TAB8|uniprotkb:Q80Y68|uniprotkb:Q9CQQ2|ensembl:ENSMUSP00000082406|ensembl:ENSMUSP00000152564	intact:EBI-6169263|ensembl:ENSP00000357177	psi-mi:daam1_mouse(display_long)|uniprotkb:Daam1(gene name)|psi-mi:Daam1(display_short)	psi-mi:o15085-2(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254103|imex:IM-17372-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273381.1|refseq:NP_080378.2|refseq:NP_766052.2|refseq:XP_006515705.1|refseq:XP_006515706.1|refseq:XP_006515707.1|ensembl:ENSMUSG00000034574(gene)|ensembl:ENSMUST00000085299(transcript)|ensembl:ENSMUST00000223272(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|reactome:R-MMU-4086400|reactome:R-MMU-5663220|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	ensembl:ENSG00000132694(gene)|ensembl:ENST00000368194(transcript)|intact:EBI-311099(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5C, 5F, 5G, Supp. Fig. 5|comment:"The interaction of DAAM1 and ARHGEF11 was greatly reduced in cells expressing Xdd1. The binding between DAAM1 and ARHGEF11 also decreased with depletion of either Dishevelled-2 or -3 and was almost undetectable after depletion of both (Figure 5G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/06/25	2014/10/16	rogid:cW/LGF6WMtPvGm1WnLA6SCN1Iqg10090	rogid:wVKtYF1CBi2ImDIOS6YMmeNTBEY9606	intact-crc:EDBABDE95581E157|rigid:SEzeG5eiAEsrpMWygMAQdL41sRI	false	myc tag:?-?	sufficient binding region:776-1562|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:15996"	uniprotkb:O15085-2	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-6169263|ensembl:ENSP00000357177	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:o15085-2(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169324|imex:IM-17372-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000132694(gene)|ensembl:ENST00000368194(transcript)|intact:EBI-311099(isoform-parent)	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5E|stimulant:DAAM1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/25	2016/08/15	-	rogid:wVKtYF1CBi2ImDIOS6YMmeNTBEY9606	intact-crc:89F6A72C66A0C2C1	false	fluorescent dye label:?-?	flag tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9Y4D1	uniprotkb:O15085-2	intact:EBI-2817289|uniprotkb:Q8N1Z8|uniprotkb:Q86U34|uniprotkb:Q8TB39|ensembl:ENSP00000378557	intact:EBI-6169263|ensembl:ENSP00000357177	psi-mi:daam1_human(display_long)|uniprotkb:DAAM1(gene name)|psi-mi:DAAM1(display_short)|uniprotkb:KIAA0666(gene name synonym)	psi-mi:o15085-2(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169285|imex:IM-17372-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005267487.1|refseq:NP_055807.1|refseq:NP_001257449.1|refseq:XP_005267488.1|ensembl:ENSG00000100592(gene)|ensembl:ENST00000395125(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|mint:Q9Y4D1|rcsb pdb:2J1D|rcsb pdb:2Z6E|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|interpro:IPR014767(Diaphanous autoregulatory)|dip:DIP-29641N	ensembl:ENSG00000132694(gene)|ensembl:ENST00000368194(transcript)|intact:EBI-311099(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/06/25	2014/10/16	rogid:nAvD3Yprt2Ayj2wLfyI15HIoyLI9606	rogid:wVKtYF1CBi2ImDIOS6YMmeNTBEY9606	intact-crc:6BE3A2399DDD39F0|rigid:QkD/f3QLqXy3NYkATN4NuN6KgFc	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15085-2	uniprotkb:Q8BPM0	intact:EBI-6169263|ensembl:ENSP00000357177	intact:EBI-772938|uniprotkb:Q6DFY0|uniprotkb:Q3UHB4|uniprotkb:Q6TAB8|uniprotkb:Q80Y68|uniprotkb:Q9CQQ2|ensembl:ENSMUSP00000082406|ensembl:ENSMUSP00000152564	psi-mi:o15085-2(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:daam1_mouse(display_long)|uniprotkb:Daam1(gene name)|psi-mi:Daam1(display_short)	psi-mi:"MI:0096"(pull down)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169303|imex:IM-17372-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132694(gene)|ensembl:ENST00000368194(transcript)|intact:EBI-311099(isoform-parent)	refseq:NP_001273381.1|refseq:NP_080378.2|refseq:NP_766052.2|refseq:XP_006515705.1|refseq:XP_006515706.1|refseq:XP_006515707.1|ensembl:ENSMUSG00000034574(gene)|ensembl:ENSMUST00000085299(transcript)|ensembl:ENSMUST00000223272(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|reactome:R-MMU-4086400|reactome:R-MMU-5663220|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148	-	isoform-comment:No experimental confirmation available.	-	figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/25	2014/10/16	rogid:wVKtYF1CBi2ImDIOS6YMmeNTBEY9606	rogid:cW/LGF6WMtPvGm1WnLA6SCN1Iqg10090	intact-crc:A7F22A674001D5AE|rigid:SEzeG5eiAEsrpMWygMAQdL41sRI	false	sufficient binding region:776-1562|glutathione s tranferase tag:?-?	myc tag:?-?|sufficient binding region:421-1077	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NYQ6	uniprotkb:Q60838	intact:EBI-718852|uniprotkb:Q9BWQ5|uniprotkb:Q9Y506|uniprotkb:Q9Y526|uniprotkb:O95722|uniprotkb:Q5TH47|ensembl:ENSP00000262738	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:celr1_human(display_long)|uniprotkb:Flamingo homolog 2(gene name synonym)|uniprotkb:CELSR1(gene name)|psi-mi:CELSR1(display_short)|uniprotkb:CDHF9(gene name synonym)|uniprotkb:FMI2(gene name synonym)|uniprotkb:Cadherin family member 9(gene name synonym)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169344|imex:IM-17372-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055061.1|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0045176"(apical protein localization)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060488"(orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060489"(planar dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060490"(lateral sprouting involved in lung morphogenesis)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001791(Laminin G)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002126(Cadherin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR017981|interpro:IPR020894|interpro:IPR032471|interpro:IPR036445|ensembl:ENSG00000075275(gene)|ensembl:ENST00000262738(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	go:"GO:0005911"(cell-cell junction)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2012/06/25	2014/10/16	rogid:X2XbcMoTf3H1SeO8g14DwFZuWI09606	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	intact-crc:927C6051FF08CC96|rigid:yWVfe1Wd6jODXKNY57l5G4meGj4	false	myc tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9NYQ6	uniprotkb:Q61089	intact:EBI-718852|uniprotkb:Q9BWQ5|uniprotkb:Q9Y506|uniprotkb:Q9Y526|uniprotkb:O95722|uniprotkb:Q5TH47|ensembl:ENSP00000262738	intact:EBI-6169353|ensembl:ENSMUSP00000022906|ensembl:ENSMUSP00000136328	psi-mi:celr1_human(display_long)|uniprotkb:Flamingo homolog 2(gene name synonym)|uniprotkb:CELSR1(gene name)|psi-mi:CELSR1(display_short)|uniprotkb:CDHF9(gene name synonym)|uniprotkb:FMI2(gene name synonym)|uniprotkb:Cadherin family member 9(gene name synonym)	psi-mi:fzd6_mouse(display_long)|uniprotkb:Fzd6(gene name)|psi-mi:Fzd6(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6169344|imex:IM-17372-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055061.1|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0045176"(apical protein localization)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060488"(orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060489"(planar dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060490"(lateral sprouting involved in lung morphogenesis)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001791(Laminin G)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002126(Cadherin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR017981|interpro:IPR020894|interpro:IPR032471|interpro:IPR036445|ensembl:ENSG00000075275(gene)|ensembl:ENST00000262738(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)	go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-MMU-4086398|reactome:R-MMU-4086400|reactome:R-MMU-4641263|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001942"(hair follicle development)|ensembl:ENSMUSG00000022297(gene)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSMUST00000022906(transcript)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|ensembl:ENSMUST00000179165(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001843"(neural tube closure)|go:"GO:0035880"(embryonic nail plate morphogenesis)|refseq:NP_001155966.1|refseq:NP_032082.3|refseq:XP_017171919.1	go:"GO:0005911"(cell-cell junction)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2012/06/25	2014/10/16	rogid:X2XbcMoTf3H1SeO8g14DwFZuWI09606	rogid:dQtslZfFmVfL8OIWimxOA06NTns10090	intact-crc:927C6051FF08CC96|rigid:yWVfe1Wd6jODXKNY57l5G4meGj4	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9NYQ6	uniprotkb:Q60838	intact:EBI-718852|uniprotkb:Q9BWQ5|uniprotkb:Q9Y506|uniprotkb:Q9Y526|uniprotkb:O95722|uniprotkb:Q5TH47|ensembl:ENSP00000262738	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	psi-mi:celr1_human(display_long)|uniprotkb:Flamingo homolog 2(gene name synonym)|uniprotkb:CELSR1(gene name)|psi-mi:CELSR1(display_short)|uniprotkb:CDHF9(gene name synonym)|uniprotkb:FMI2(gene name synonym)|uniprotkb:Cadherin family member 9(gene name synonym)	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Nishimura et al. (2012)	pubmed:22632972|imex:IM-17372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6254182|imex:IM-17372-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055061.1|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0045176"(apical protein localization)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060488"(orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060489"(planar dichotomous subdivision of terminal units involved in lung branching morphogenesis)|go:"GO:0060490"(lateral sprouting involved in lung morphogenesis)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001791(Laminin G)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002126(Cadherin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR017981|interpro:IPR020894|interpro:IPR032471|interpro:IPR036445|ensembl:ENSG00000075275(gene)|ensembl:ENST00000262738(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	go:"GO:0005911"(cell-cell junction)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2012/06/25	2014/10/16	rogid:X2XbcMoTf3H1SeO8g14DwFZuWI09606	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	intact-crc:67CCB632CB6950C9|rigid:Rt0R9xrfpmipN08/BfrfT033HHo	false	myc tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)