#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chembl target:CHEMBL2095226	uniprotkb:O15232	intact:EBI-2550721|reactome:R-HSA-202730|matrixdb:MULT_15_human|wwpdb:3vi3|signor:SIGNOR-C163	intact:EBI-6262458|ensembl:ENSP00000383894|uniprotkb:B2CPU0|uniprotkb:Q4ZG02	psi-mi:intg_a5_b1_human(display_short)|psi-mi:CHEMBL2095226(display_long)|intact:alpha-5/beta-1 integrin complex(complex synonym)|intact:alpha5-beta1 integrin complex(complex synonym)|intact:"ITGA5:ITGB1"(complex systematic name)|intact:Integrin alpha5-beta1 complex(complex recommended name)	psi-mi:matn3_human(display_long)|uniprotkb:MATN3(gene name)|psi-mi:MATN3(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Vincourt et al. (2012)	pubmed:22521401|imex:IM-17880	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6262477|imex:IM-17880-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0034674"(integrin alpha5-beta1 complex)|complex portal:CPX-1794(complex-primary)|evidence ontology:"ECO:0000353"|intact:EBI-26987514(exp-evidence)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)	ensembl:ENST00000407540(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000132031(gene)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030765|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_002372.1	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for fibronectin and fibrinogen which its binds via the sequence R-G-D in the ligand.|complex-properties:The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|ligand:"Fibronectin (P02751)"|complex-assembly:Heterodimer	-	figure legend:2D, 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:30.0x10^-9(molar)	2012/08/02	2017/01/05	-	rogid:xaqtpmkOEndqB+T3wmDsDErSS8k9606	intact-crc:659F77493CBB85E0	false	sufficient binding region:?-?	his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P49747	uniprotkb:O15232	intact:EBI-2531022|uniprotkb:O14592|uniprotkb:Q16388|uniprotkb:Q16389|uniprotkb:Q2NL86|uniprotkb:Q8N4T2|ensembl:ENSP00000222271|uniprotkb:B4DKJ3	intact:EBI-6262458|ensembl:ENSP00000383894|uniprotkb:B2CPU0|uniprotkb:Q4ZG02	psi-mi:comp_human(display_long)|uniprotkb:COMP(gene name)|psi-mi:COMP(display_short)|uniprotkb:Thrombospondin-5(gene name synonym)	psi-mi:matn3_human(display_long)|uniprotkb:MATN3(gene name)|psi-mi:MATN3(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Vincourt et al. (2012)	pubmed:22521401|imex:IM-17880	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6262487|imex:IM-17880-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000086.2|go:"GO:0016485"(protein processing)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0035989"(tendon development)|go:"GO:0036122"(BMP binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043588"(skin development)|go:"GO:0048844"(artery morphogenesis)|ensembl:ENSG00000105664(gene)|ensembl:ENST00000222271(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008201"(heparin binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010260"(animal organ senescence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0060173"(limb development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1900047"(negative regulation of hemostasis)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR018097|interpro:IPR024665|interpro:IPR028492|interpro:IPR028974|interpro:IPR039081|rcsb pdb:3FBY|reactome:R-HSA-216083|reactome:R-HSA-3000178	ensembl:ENST00000407540(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000132031(gene)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030765|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_002372.1	-	-	-	figure legend:Suppl Fig1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/02	2014/10/16	rogid:PEd7Bm1+z4Pzcq6aU8JJ2ogPMyY9606	rogid:xaqtpmkOEndqB+T3wmDsDErSS8k9606	intact-crc:D4A78AED6D8E7414|rigid:tJ9lkp/sxmOUlWX15Qq58+Z+gNo	false	his tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)