#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14727	uniprotkb:P62258	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0096"(pull down)	Kim et al. (2012)	doi:10.1038/emboj.2011.491|pubmed:22246185|imex:IM-18776|mint:MINT-8384310	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7643293|mint:MINT-8384318|imex:IM-18776-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|mint:MINT-8384321(identity)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8384320(identity)	-	-	-	figure legend:F5F|comment:homomint|comment:domino|comment:mint|comment:"14-3-3 epsilon has been detected as endougenously expressed in green monkey cells (COS-7); since its accession number needs to be updated we have adopted the human isoform of the protein, because the antibody also recognizes the human isoform."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/26	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:1B3AB2715615799C|rigid:HrBIGSEOWXYVAwn9YnIT9r6uX6c	false	his tag:?-?(MINT-8384327)|mutation decreasing interaction:268-268(MINT-8384330)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14727	uniprotkb:P62258	intact:EBI-446492|uniprotkb:B2RMX8|uniprotkb:O43297|uniprotkb:Q7Z438|uniprotkb:Q9BXZ6|uniprotkb:Q9UBZ5|uniprotkb:Q9UGN8|uniprotkb:Q9UGN9|uniprotkb:Q9UGP0|uniprotkb:Q9UJ58|uniprotkb:Q9UJ59|uniprotkb:Q9UJ60|uniprotkb:Q9UJ61|uniprotkb:Q9UJ62|uniprotkb:Q9UJ63|uniprotkb:Q9UJ64|uniprotkb:Q9UJ65|uniprotkb:Q9UJ66|uniprotkb:Q9UJ67|uniprotkb:Q9UNC9|ensembl:ENSP00000448165	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:apaf_human(display_long)|uniprotkb:APAF1(gene name)|psi-mi:APAF1(display_short)|uniprotkb:KIAA0413(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0096"(pull down)	Kim et al. (2012)	doi:10.1038/emboj.2011.491|pubmed:22246185|imex:IM-18776|mint:MINT-8384310	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7643315|mint:MINT-8384334|imex:IM-18776-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001151.1|refseq:NP_037361.1|refseq:NP_863651.1|refseq:NP_863658.1|refseq:NP_863659.1|dip:DIP-27624N|interpro:IPR042197|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030154"(cell differentiation)|mint:O14727|rcsb pdb:1C15|go:"GO:0031072"(heat shock protein binding)|rcsb pdb:1CWW|rcsb pdb:1CY5|rcsb pdb:1Z6T|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:2P1H|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:2YGS|rcsb pdb:3J2T|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:3JBT|rcsb pdb:3YGS|go:"GO:0043293"(apoptosome)|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|go:"GO:0043531"(ADP binding)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5WVE|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072432"(response to G1 DNA damage checkpoint signaling)|reactome:R-HSA-111458|reactome:R-HSA-111459|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|reactome:R-HSA-111463|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|reactome:R-HSA-111464|interpro:IPR011029(DEATH-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6798695|interpro:IPR017251(Apoptotic protease-activating factor 1)|interpro:IPR019775|reactome:R-HSA-6803207|interpro:IPR020472|reactome:R-HSA-8953750|interpro:IPR027417|reactome:R-HSA-9627069|interpro:IPR036322|interpro:IPR036388|interpro:IPR037963|interpro:IPR041452|ensembl:ENSG00000120868(gene)|ensembl:ENST00000551964(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|mint:MINT-8384338(identity)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8384336(identity)	-	-	-	figure legend:F5F|comment:homomint|comment:domino|comment:mint|comment:"14-3-3 epsilon has been detected as endougenously expressed in green monkey cells (COS-7); since its accession number needs to be updated we have adopted the human isoform of the protein, because the antibody also recognizes the human isoform."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/26	2014/10/16	rogid:/jz44wizyUPTNZLQtgjh7YLt/mE9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:F2D42E81D2D44965|rigid:HrBIGSEOWXYVAwn9YnIT9r6uX6c	false	his tag:?-?(MINT-8384341)|mutation decreasing interaction:357-357(MINT-8384339)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)