#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UBC3-1 uniprotkb:Q9UKY1 intact:EBI-6083193|ensembl:ENSP00000328547 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5328320 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:1A|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/01/23 2014/10/16 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:373A879ED5A615C0|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UBC3-1 uniprotkb:Q9UKY1 intact:EBI-6083193|ensembl:ENSP00000328547 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5328336 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:1B|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/01/23 2014/10/16 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:5AF670F21696205B|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBC3-1 uniprotkb:Q9UKY1 intact:EBI-6083193|ensembl:ENSP00000328547 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5328331 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:1B|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/01/23 2014/10/16 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:EA346121209DE428|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBC3-1 uniprotkb:Q9UKY1 intact:EBI-6083193|ensembl:ENSP00000328547 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0428"(imaging technique) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-5328347 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) go:"GO:0005634"(nucleus) - - figure legend:3B|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/01/23 2014/10/16 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:80C14FA486A10ADA|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false green fluorescent protein tag:?-? myc tag:?-? - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q9UKY1 uniprotkb:Q9UBC3-1 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 intact:EBI-6083193|ensembl:ENSP00000328547 psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:"MI:0096"(pull down) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-9827755 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) - - - figure legend:Fig. 2a|causality statement:Q9UKY1 increases activity of Q9UBC3-1|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/01/23 2014/10/16 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 intact-crc:35189F5A6B9694F2|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false 35s radiolabel:?-? glutathione s tranferase tag:?-?|sufficient binding region:1-360(IPR000313) - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q9UBC3-1 uniprotkb:Q9UKY1 intact:EBI-6083193|ensembl:ENSP00000328547 intact:EBI-347767|uniprotkb:Q8IWD8|intact:EBI-28969235|ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821 psi-mi:q9ubc3-1(display_long)|uniprotkb:DNMT3B(gene name)|psi-mi:DNMT3B(display_short)|uniprotkb:DNA methyltransferase HsaIIIB(gene name synonym) psi-mi:zhx1_human(display_long)|uniprotkb:ZHX1(gene name)|psi-mi:ZHX1(display_short) psi-mi:"MI:0096"(pull down) Kim et al. (2007) pubmed:17303076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-9827767 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-80125(isoform-parent)|ensembl:ENSG00000088305(gene)|ensembl:ENST00000328111(transcript) ensembl:ENSP00000297857|ensembl:ENSP00000378938|ensembl:ENSP00000428821|refseq:NP_001017926.1|refseq:NP_009153.3|ensembl:ENSG00000165156(gene)|ensembl:ENST00000297857(transcript)|ensembl:ENST00000395571(transcript)|ensembl:ENST00000522655(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR024578|interpro:IPR036236|interpro:IPR041057|rcsb pdb:2ECB|rcsb pdb:2GHF|rcsb pdb:2LY9|rcsb pdb:3NAR|interpro:IPR001356(Homeobox) - - - figure legend:Fig. 2b|dataset:IBD - Inflammatory bowel disease|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/01/23 2014/10/16 rogid:xxbu/yvuQ1KnhVE/FdTh9CyA6jw9606 rogid:WAYc3kUjWyhNmhghUHlhYlLFxdc9606 intact-crc:BF9AA79E47F0492D|rigid:7MNxW9wO53AMZmc8CDmq5K6kGww false 35s radiolabel:?-? sufficient binding region:272-564(IPR001356)|sufficient binding region:565-732(IPR001356)|glutathione s tranferase tag:?-?|sufficient binding region:733-873(IPR001356) - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)