#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O97102 uniprotkb:Q9VNJ0 intact:EBI-114439|ensemblmetazoa:FBpp0078984|ensemblmetazoa:FBpp0312327 intact:EBI-186615|ensemblmetazoa:FBpp0078287 psi-mi:o97102_drome(display_long)|uniprotkb:smt3(gene name)|psi-mi:smt3(display_short)|uniprotkb:Smt3(gene name synonym)|uniprotkb:DmSUMO-1(gene name synonym)|uniprotkb:Dm0342(gene name synonym)|uniprotkb:DmSmt3(gene name synonym)|uniprotkb:Dmel\CG4494(gene name synonym)|uniprotkb:Dmsmt3(gene name synonym)|uniprotkb:SMT3(gene name synonym)|uniprotkb:SUMO(gene name synonym)|uniprotkb:Sumo(gene name synonym)|uniprotkb:"anon-EST:Posey240"(gene name synonym)|uniprotkb:dSmt3(gene name synonym)|uniprotkb:dsmt3(gene name synonym)|uniprotkb:"l(2)04493"(gene name synonym)|uniprotkb:"l(2)SH0182"(gene name synonym)|uniprotkb:"l(2)SH2 0182"(gene name synonym)|uniprotkb:CG4494(orf name)|uniprotkb:sumo(gene name synonym)|uniprotkb:Dmel_CG4494(orf name) psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8598176|mint:MINT-8173759|imex:IM-15874-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477411.1|go:"GO:0000940"(outer kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|ensemblmetazoa:FBgn0264922(gene)|ensemblmetazoa:FBtr0079356(transcript)|ensemblmetazoa:FBtr0346716(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030496"(midbody)|go:"GO:0031386"(protein tag)|go:"GO:0035073"(pupariation)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:O97102|rcsb pdb:2K1F|reactome:R-DME-196791|reactome:R-DME-3065679|reactome:R-DME-3108214|reactome:R-DME-3232118|reactome:R-DME-3899300|reactome:R-DME-4090294|reactome:R-DME-4551638|reactome:R-DME-4570464|reactome:R-DME-4615885|reactome:R-DME-4755510|reactome:R-DME-5696395|refseq:NP_001303312.1|flybase:FBgn0264922|mint:MINT-8173762(identity) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8173761(identity) go:"GO:0005634"(nucleus) - - figure legend:f1f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo) - 2011/04/27 2014/10/16 rogid:fqo3Y86DDI0SsWGEfanaOs8qJlk7227 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 intact-crc:89EA572278E32C4B|rigid:KAymYb8Z8iG4PezXDCkmOT0FcGI false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q9VNJ0 uniprotkb:O97102 intact:EBI-186615|ensemblmetazoa:FBpp0078287 intact:EBI-114439|ensemblmetazoa:FBpp0078984|ensemblmetazoa:FBpp0312327 psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:o97102_drome(display_long)|uniprotkb:smt3(gene name)|psi-mi:smt3(display_short)|uniprotkb:Smt3(gene name synonym)|uniprotkb:DmSUMO-1(gene name synonym)|uniprotkb:Dm0342(gene name synonym)|uniprotkb:DmSmt3(gene name synonym)|uniprotkb:Dmel\CG4494(gene name synonym)|uniprotkb:Dmsmt3(gene name synonym)|uniprotkb:SMT3(gene name synonym)|uniprotkb:SUMO(gene name synonym)|uniprotkb:Sumo(gene name synonym)|uniprotkb:"anon-EST:Posey240"(gene name synonym)|uniprotkb:dSmt3(gene name synonym)|uniprotkb:dsmt3(gene name synonym)|uniprotkb:"l(2)04493"(gene name synonym)|uniprotkb:"l(2)SH0182"(gene name synonym)|uniprotkb:"l(2)SH2 0182"(gene name synonym)|uniprotkb:CG4494(orf name)|uniprotkb:sumo(gene name synonym)|uniprotkb:Dmel_CG4494(orf name) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8598198|mint:MINT-8198306|imex:IM-15874-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198309(identity) refseq:NP_477411.1|go:"GO:0000940"(outer kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|ensemblmetazoa:FBgn0264922(gene)|ensemblmetazoa:FBtr0079356(transcript)|ensemblmetazoa:FBtr0346716(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030496"(midbody)|go:"GO:0031386"(protein tag)|go:"GO:0035073"(pupariation)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:O97102|rcsb pdb:2K1F|reactome:R-DME-196791|reactome:R-DME-3065679|reactome:R-DME-3108214|reactome:R-DME-3232118|reactome:R-DME-3899300|reactome:R-DME-4090294|reactome:R-DME-4551638|reactome:R-DME-4570464|reactome:R-DME-4615885|reactome:R-DME-4755510|reactome:R-DME-5696395|refseq:NP_001303312.1|flybase:FBgn0264922|mint:MINT-8198311(identity) - - - figure legend:f1g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/27 2014/10/16 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 rogid:fqo3Y86DDI0SsWGEfanaOs8qJlk7227 intact-crc:A0577CDC6FB9CF7D|rigid:KAymYb8Z8iG4PezXDCkmOT0FcGI false his tag:?-?(MINT-8198331) glutathione s tranferase tag:?-?(MINT-8198350) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14003 uniprotkb:Q9VNJ0 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 intact:EBI-186615|ensemblmetazoa:FBpp0078287 psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8598230|mint:MINT-8198369|imex:IM-15874-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198375(identity) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198371(identity) - - - comment:mint|figure legend:f1i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/27 2014/10/16 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 intact-crc:AC8F2F6F1BB5F5FA|rigid:UNry3hvy0VgxBTyfGNEYgKVnjIE false his tag:?-?(MINT-8198386) mutation disrupting interaction:302-302(MINT-8198382)|mutation disrupting interaction:300-300(MINT-8198379)|glutathione s tranferase tag:?-?(MINT-8198372) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VNJ0 uniprotkb:P14003 intact:EBI-186615|ensemblmetazoa:FBpp0078287 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8598216|mint:MINT-8198354|imex:IM-15874-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198356(identity) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198360(identity) - - - comment:mint|figure legend:f1h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/27 2014/10/16 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 intact-crc:1FE27189367765B7|rigid:UNry3hvy0VgxBTyfGNEYgKVnjIE false glutathione s tranferase tag:?-?(MINT-8198357) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P14003 uniprotkb:Q9VNJ0 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 intact:EBI-186615|ensemblmetazoa:FBpp0078287 psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8598272|mint:MINT-8198408|imex:IM-15874-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198412(identity) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198410(identity) - - - comment:mint|figure legend:sf1b sf1c sf5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/27 2014/10/16 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 intact-crc:59252432F785942B|rigid:UNry3hvy0VgxBTyfGNEYgKVnjIE false mutation disrupting interaction:29-48(MINT-8198439) glutathione s tranferase tag:?-?(MINT-8198446) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VNJ0 uniprotkb:P14003 intact:EBI-186615|ensemblmetazoa:FBpp0078287 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8598255|mint:MINT-8198389|imex:IM-15874-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198391(identity) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198399(identity) - - - comment:mint|figure legend:f1j|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/04/27 2014/10/16 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 intact-crc:C284B5C5B28BD437|rigid:UNry3hvy0VgxBTyfGNEYgKVnjIE false - glutathione s tranferase tag:?-?(MINT-8198400)|binding-associated region:1-100(MINT-8206912) - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14003 uniprotkb:P16371 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 intact:EBI-153866|intact:EBI-1639108|uniprotkb:Q0KI08|uniprotkb:Q7KRZ4|uniprotkb:Q9V3F7|uniprotkb:A4V3F6|ensemblmetazoa:FBpp0089115 psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:grou_drome(display_long)|uniprotkb:gro(gene name)|psi-mi:gro(display_short)|uniprotkb:"E(spl)m9/m10"(gene name synonym)|uniprotkb:CG8384(orf name)|uniprotkb:Enhancer of split m9/10 protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8598367|mint:MINT-8198526|imex:IM-15874-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198532(identity) refseq:NP_001189293.1|refseq:NP_524514.2|refseq:NP_733133.1|refseq:NP_733134.1|refseq:NP_733135.1|refseq:NP_996298.1|flybase:FBgn0001139|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071906"(CRD domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P16371|reactome:R-DME-201722|reactome:R-DME-209421|reactome:R-DME-209441|reactome:R-DME-3769402|reactome:R-DME-4641265|go:"GO:0045751"(negative regulation of Toll signaling pathway)|ensemblmetazoa:FBgn0001139(gene)|ensemblmetazoa:FBtr0084966(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007541"("sex determination, primary response to X:A ratio")|go:"GO:0008134"(transcription factor binding)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|dip:DIP-40N|mint:MINT-8198528(identity) - - - comment:mint|figure legend:f1k|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/04/27 2014/10/16 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 rogid:oSo29NrCWIeCi2OMusohCk64uiw7227 intact-crc:A4D456DE14D0F3DD|rigid:FHdrglr3JteKqIwUuxGzJp7BT8k false fusion protein:?-?(MINT-8198538)|binding-associated region:334-337(MINT-8198535) fusion protein:?-?(MINT-8198529) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VNJ0 uniprotkb:P14003 intact:EBI-186615|ensemblmetazoa:FBpp0078287 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 psi-mi:q9vnj0_drome(display_long)|uniprotkb:dgrn(gene name)|psi-mi:dgrn(display_short)|uniprotkb:Dgrn(gene name synonym)|uniprotkb:Dmel\CG10981(gene name synonym)|uniprotkb:STUbL(gene name synonym)|uniprotkb:Dmel_CG10981(orf name)|uniprotkb:CG10981(orf name) psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:"MI:0018"(two hybrid) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8598324|mint:MINT-8198480|imex:IM-15874-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_649596.1|flybase:FBgn0037384|ensemblmetazoa:FBgn0037384(gene)|ensemblmetazoa:FBtr0078638(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007530"(sex determination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032183"(SUMO binding)|go:"GO:0033768"(SUMO-targeted ubiquitin ligase complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0061059"(positive regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9VNJ0|reactome:R-DME-983168|mint:MINT-8198482(identity) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198486(identity) - - - comment:domino|comment:mint|figure legend:f1k|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/04/27 2014/10/16 rogid:b0Zd0DhpPvxAfKQBvlUxSdmG09c7227 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 intact-crc:AECFAAE9EFA4DE5B|rigid:UNry3hvy0VgxBTyfGNEYgKVnjIE false fusion protein:?-?(MINT-8198483) fusion protein:?-?(MINT-8198499)|mutation decreasing interaction:33-33(MINT-8198487)|binding-associated region:29-89(MINT-8198501) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O46036 uniprotkb:P14003 intact:EBI-159330|uniprotkb:O61283|uniprotkb:Q59DX5|ensemblmetazoa:FBpp0099514|uniprotkb:Q95SQ8|uniprotkb:Q9VG02 intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504 psi-mi:ctbp_drome(display_long)|uniprotkb:CtBP(gene name)|psi-mi:CtBP(display_short)|uniprotkb:CG7583(orf name)|uniprotkb:dCtBP(gene name synonym) psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short) psi-mi:"MI:0018"(two hybrid) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8598350|mint:MINT-8198506|imex:IM-15874-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014617.1|refseq:NP_524336.2|refseq:NP_731762.1|refseq:NP_731763.1|refseq:NP_731764.1|flybase:FBgn0020496|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0022416"(chaeta development)|go:"GO:0031010"(ISWI-type complex)|go:"GO:0035220"(wing disc development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051287"(NAD binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:O46036|reactome:R-DME-3769402|go:"GO:0008134"(transcription factor binding)|ensemblmetazoa:FBgn0020496(gene)|ensemblmetazoa:FBtr0100161(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-DME-3899300|reactome:R-DME-4641265|refseq:NP_001262520.1|dip:DIP-17268N|mint:MINT-8198508(identity) refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N|mint:MINT-8198512(identity) - - - comment:mint|figure legend:f1k|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2011/04/27 2014/10/16 rogid:hbMeldNlirFwVr+5QX9bGiPqZ1w7227 rogid:bO023bTsk72HhqvmgSjLEIotrDw7227 intact-crc:C7D3963C5D7818AF|rigid:6SxefJVI+l+gOYH86/l/XVmVe/0 false fusion protein:?-?(MINT-8198509) fusion protein:?-?(MINT-8198518) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O97102 uniprotkb:P16371 intact:EBI-114439|ensemblmetazoa:FBpp0078984|ensemblmetazoa:FBpp0312327 intact:EBI-153866|intact:EBI-1639108|uniprotkb:Q0KI08|uniprotkb:Q7KRZ4|uniprotkb:Q9V3F7|uniprotkb:A4V3F6|ensemblmetazoa:FBpp0089115 psi-mi:o97102_drome(display_long)|uniprotkb:smt3(gene name)|psi-mi:smt3(display_short)|uniprotkb:Smt3(gene name synonym)|uniprotkb:DmSUMO-1(gene name synonym)|uniprotkb:Dm0342(gene name synonym)|uniprotkb:DmSmt3(gene name synonym)|uniprotkb:Dmel\CG4494(gene name synonym)|uniprotkb:Dmsmt3(gene name synonym)|uniprotkb:SMT3(gene name synonym)|uniprotkb:SUMO(gene name synonym)|uniprotkb:Sumo(gene name synonym)|uniprotkb:"anon-EST:Posey240"(gene name synonym)|uniprotkb:dSmt3(gene name synonym)|uniprotkb:dsmt3(gene name synonym)|uniprotkb:"l(2)04493"(gene name synonym)|uniprotkb:"l(2)SH0182"(gene name synonym)|uniprotkb:"l(2)SH2 0182"(gene name synonym)|uniprotkb:CG4494(orf name)|uniprotkb:sumo(gene name synonym)|uniprotkb:Dmel_CG4494(orf name) psi-mi:grou_drome(display_long)|uniprotkb:gro(gene name)|psi-mi:gro(display_short)|uniprotkb:"E(spl)m9/m10"(gene name synonym)|uniprotkb:CG8384(orf name)|uniprotkb:Enhancer of split m9/10 protein(gene name synonym) psi-mi:"MI:0096"(pull down) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8598396|mint:MINT-8198544|imex:IM-15874-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477411.1|go:"GO:0000940"(outer kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|ensemblmetazoa:FBgn0264922(gene)|ensemblmetazoa:FBtr0079356(transcript)|ensemblmetazoa:FBtr0346716(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030496"(midbody)|go:"GO:0031386"(protein tag)|go:"GO:0035073"(pupariation)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:O97102|rcsb pdb:2K1F|reactome:R-DME-196791|reactome:R-DME-3065679|reactome:R-DME-3108214|reactome:R-DME-3232118|reactome:R-DME-3899300|reactome:R-DME-4090294|reactome:R-DME-4551638|reactome:R-DME-4570464|reactome:R-DME-4615885|reactome:R-DME-4755510|reactome:R-DME-5696395|refseq:NP_001303312.1|flybase:FBgn0264922|mint:MINT-8198550(identity) refseq:NP_001189293.1|refseq:NP_524514.2|refseq:NP_733133.1|refseq:NP_733134.1|refseq:NP_733135.1|refseq:NP_996298.1|flybase:FBgn0001139|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071906"(CRD domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P16371|reactome:R-DME-201722|reactome:R-DME-209421|reactome:R-DME-209441|reactome:R-DME-3769402|reactome:R-DME-4641265|go:"GO:0045751"(negative regulation of Toll signaling pathway)|ensemblmetazoa:FBgn0001139(gene)|ensemblmetazoa:FBtr0084966(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007541"("sex determination, primary response to X:A ratio")|go:"GO:0008134"(transcription factor binding)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|dip:DIP-40N|mint:MINT-8198546(identity) - - - comment:homomint|comment:mint|figure legend:f5c sf3f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2011/04/27 2014/10/16 rogid:fqo3Y86DDI0SsWGEfanaOs8qJlk7227 rogid:oSo29NrCWIeCi2OMusohCk64uiw7227 intact-crc:19AE957549AF2462|rigid:uCoU3j9avPM/TSg/rBvTNMoxgdU false his tag:?-?(MINT-8198551) ha tag:?-?(MINT-8198547) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P16371 uniprotkb:O97102 intact:EBI-153866|intact:EBI-1639108|uniprotkb:Q0KI08|uniprotkb:Q7KRZ4|uniprotkb:Q9V3F7|uniprotkb:A4V3F6|ensemblmetazoa:FBpp0089115 intact:EBI-114439|ensemblmetazoa:FBpp0078984|ensemblmetazoa:FBpp0312327 psi-mi:grou_drome(display_long)|uniprotkb:gro(gene name)|psi-mi:gro(display_short)|uniprotkb:"E(spl)m9/m10"(gene name synonym)|uniprotkb:CG8384(orf name)|uniprotkb:Enhancer of split m9/10 protein(gene name synonym) psi-mi:o97102_drome(display_long)|uniprotkb:smt3(gene name)|psi-mi:smt3(display_short)|uniprotkb:Smt3(gene name synonym)|uniprotkb:DmSUMO-1(gene name synonym)|uniprotkb:Dm0342(gene name synonym)|uniprotkb:DmSmt3(gene name synonym)|uniprotkb:Dmel\CG4494(gene name synonym)|uniprotkb:Dmsmt3(gene name synonym)|uniprotkb:SMT3(gene name synonym)|uniprotkb:SUMO(gene name synonym)|uniprotkb:Sumo(gene name synonym)|uniprotkb:"anon-EST:Posey240"(gene name synonym)|uniprotkb:dSmt3(gene name synonym)|uniprotkb:dsmt3(gene name synonym)|uniprotkb:"l(2)04493"(gene name synonym)|uniprotkb:"l(2)SH0182"(gene name synonym)|uniprotkb:"l(2)SH2 0182"(gene name synonym)|uniprotkb:CG4494(orf name)|uniprotkb:sumo(gene name synonym)|uniprotkb:Dmel_CG4494(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Abed et al. (2011) mint:MINT-8173751|pubmed:21343912|imex:IM-15874|doi:10.1038/emboj.2011.42 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8598423|mint:MINT-8198564|imex:IM-15874-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001189293.1|refseq:NP_524514.2|refseq:NP_733133.1|refseq:NP_733134.1|refseq:NP_733135.1|refseq:NP_996298.1|flybase:FBgn0001139|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071906"(CRD domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P16371|reactome:R-DME-201722|reactome:R-DME-209421|reactome:R-DME-209441|reactome:R-DME-3769402|reactome:R-DME-4641265|go:"GO:0045751"(negative regulation of Toll signaling pathway)|ensemblmetazoa:FBgn0001139(gene)|ensemblmetazoa:FBtr0084966(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007541"("sex determination, primary response to X:A ratio")|go:"GO:0008134"(transcription factor binding)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|dip:DIP-40N|mint:MINT-8198570(identity) refseq:NP_477411.1|go:"GO:0000940"(outer kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|ensemblmetazoa:FBgn0264922(gene)|ensemblmetazoa:FBtr0079356(transcript)|ensemblmetazoa:FBtr0346716(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002225"(positive regulation of antimicrobial peptide production)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016925"(protein sumoylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030496"(midbody)|go:"GO:0031386"(protein tag)|go:"GO:0035073"(pupariation)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045752"(positive regulation of Toll signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:O97102|rcsb pdb:2K1F|reactome:R-DME-196791|reactome:R-DME-3065679|reactome:R-DME-3108214|reactome:R-DME-3232118|reactome:R-DME-3899300|reactome:R-DME-4090294|reactome:R-DME-4551638|reactome:R-DME-4570464|reactome:R-DME-4615885|reactome:R-DME-4755510|reactome:R-DME-5696395|refseq:NP_001303312.1|flybase:FBgn0264922|mint:MINT-8198566(identity) - - - comment:homomint|comment:mint|figure legend:f5d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2011/04/27 2014/10/16 rogid:oSo29NrCWIeCi2OMusohCk64uiw7227 rogid:fqo3Y86DDI0SsWGEfanaOs8qJlk7227 intact-crc:4D9DED5301927901|rigid:uCoU3j9avPM/TSg/rBvTNMoxgdU false ha tag:?-?(MINT-8198571) his tag:?-?(MINT-8198567) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant)