#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15379	uniprotkb:Q8TF05	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	intact:EBI-1056262|uniprotkb:Q99774|uniprotkb:Q9UNQ7|ensembl:ENSP00000383402	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:pp4r1_human(display_long)|uniprotkb:PPP4R1(gene name)|psi-mi:PPP4R1(display_short)|uniprotkb:MEG1(gene name synonym)|uniprotkb:PP4R1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2005)	doi:10.1101/gad.1286005|pubmed:15805470|mint:MINT-8223871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7573239|mint:MINT-8246542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-8246544(identity)	refseq:NP_001035847.1|refseq:NP_005125.1|ensembl:ENSG00000154845(gene)|ensembl:ENST00000400556(transcript)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030289"(protein phosphatase 4 complex)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031087|interpro:IPR033461|mint:Q8TF05|mint:MINT-8246545(identity)	-	-	-	comment:mint|figure legend:F4A-F;F5|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/20	2014/10/16	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	rogid:c7WdQEzkeS6LDpC2GD9czxBdWj09606	intact-crc:B991EE28D826A0C3|rigid:PC42o0PFURFk0TMdUlYoMjfhlkQ	false	mutation disrupting interaction:122-428(MINT-8246766)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15379	uniprotkb:P60510	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2005)	doi:10.1101/gad.1286005|pubmed:15805470|mint:MINT-8223871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7573271|mint:MINT-8246695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-8246697(identity)	refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|mint:MINT-8246698(identity)	-	-	-	comment:mint|figure legend:F4a-F|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/10/20	2014/10/16	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606	intact-crc:C2BB7E61C05A32F9|rigid:x8viy0jjEyraxl9RHsWXrEp8M2s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15379	uniprotkb:P60510	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	intact:EBI-1046072|uniprotkb:P33172|ensembl:ENSP00000279387|ensembl:ENSP00000455995	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:pp4c_human(display_long)|uniprotkb:Protein phosphatase X(gene name synonym)|uniprotkb:PPP4C(gene name)|psi-mi:PPP4C(display_short)|uniprotkb:PPP4(gene name synonym)|uniprotkb:PPX(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2005)	doi:10.1101/gad.1286005|pubmed:15805470|mint:MINT-8223871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7573308|mint:MINT-8246634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-8246637(identity)	refseq:NP_002711.1|refseq:NP_001290432.1|refseq:NP_001290433.1|refseq:NP_001290435.1|refseq:NP_001290436.1|ensembl:ENSG00000149923(gene)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P60510|reactome:R-HSA-5693607|ensembl:ENST00000279387(transcript)|ensembl:ENST00000561610(transcript)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0030289"(protein phosphatase 4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|mint:MINT-8246638(identity)	-	-	-	comment:mint|figure legend:F4C,D|partial coverage:partial coverage|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/20	2014/10/16	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	rogid:1x3NwIpQ/T3bO/yHgAZUDqNV4989606	intact-crc:4979A6DC6FC6589C|rigid:x8viy0jjEyraxl9RHsWXrEp8M2s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)