#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12644	uniprotkb:Q96NZ8	intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym)	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499240|mint:MINT-8044124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development)|mint:MINT-8044127(identity)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ|mint:MINT-8044126(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1a t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.2x10^-7(molar)	2010/10/08	2014/10/16	rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	intact-crc:F606BD3D40B56DA3|rigid:CW7U2/IPPVpv7/Oa8ncuCfa4+yo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEU8	uniprotkb:P12644	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499272|mint:MINT-8044135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|mint:MINT-8044305(identity)	refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development)|mint:MINT-8044137(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1b t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.5x10^-8(molar)	2010/10/08	2014/10/16	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606	intact-crc:57D846A8A8C5D84A|rigid:wGlOyzhoWfy5mee6oMkB7kG51uw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96NZ8	uniprotkb:P01137	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499284|mint:MINT-8044138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ|mint:MINT-8044140(identity)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936|mint:MINT-8044141(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1c t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.5x10^-7(molar)	2010/10/08	2014/10/16	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:82AAFBB35D41C3D2|rigid:80aqlVp5iRJvI7I85BrnFbgYnrY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q96NZ8	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499296|mint:MINT-8044148	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-8044153(identity)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ|mint:MINT-8044151(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1e t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-7(molar)	2010/10/08	2014/10/16	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	intact-crc:A7090CCA20213271|rigid:2Kx3lCzFOJ5RT5HAwLjpsb6l6e8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12645	uniprotkb:Q96NZ8	intact:EBI-8464990|intact:MINT-8044327|uniprotkb:Q4VAS5|intact:EBI-8499308|ensembl:ENSP00000282701	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	psi-mi:bmp3_human(display_long)|uniprotkb:BMP3(gene name)|psi-mi:BMP3(display_short)|uniprotkb:BMP3A(gene name synonym)|uniprotkb:Bone morphogenetic protein 3A(gene name synonym)|uniprotkb:Osteogenin(gene name synonym)	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499337|mint:MINT-8044158	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192.3|ensembl:ENSG00000152785(gene)|ensembl:ENST00000282701(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017197(Bone morphogenetic protein 3/growth differentiation factor 10)|interpro:IPR017948|interpro:IPR029034|mint:P12645|rcsb pdb:2QCQ|mint:MINT-8044353(identity)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ|mint:MINT-8044161(identity)	-	comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f1g t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-6(molar)	2010/10/08	2014/10/16	rogid:U1+lOcGUPg0aJVrJ0ttIgmvUfbw9606	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	intact-crc:8F12590C8B481DB6|rigid:8GQZZ7qxaueG4InhCirjw0Q+RT8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96NZ8	uniprotkb:P34820	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	intact:EBI-1752660|uniprotkb:E7EMY8|uniprotkb:Q32NE5|uniprotkb:Q53ZM7|uniprotkb:Q9NUF0|ensembl:ENSP00000361915	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:bmp8b_human(display_long)|uniprotkb:BMP8B(gene name)|psi-mi:BMP8B(display_short)|uniprotkb:BMP8(gene name synonym)|uniprotkb:Osteogenic protein 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499349|mint:MINT-8044168	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ|mint:MINT-8044171(identity)	refseq:NP_001711.2|ensembl:ENSG00000116985(gene)|ensembl:ENST00000372827(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0051216"(cartilage development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070700"(BMP receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:MINT-8044173(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1i t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.0x10^-5(molar)	2010/10/08	2014/10/16	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	rogid:AoeJiVsmENXITnhH/oX8oZXQwIk9606	intact-crc:10E6421D0BA7F4B9|rigid:SEzgBtUQP4WJXEGoyopnSbGHuVA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P12643	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499488|mint:MINT-8044230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N|mint:MINT-8044232(identity)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-8044233(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3a f3c f3e t2	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-10(molar)	2010/10/08	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	intact-crc:B6E0B321B8158239|rigid:uOjo+k6ntioajh3WtYrnaTHK4Ts	false	binding-associated region:24-152(MINT-8044237)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13705	uniprotkb:O95390	intact:EBI-1383577|uniprotkb:Q4VAV0|ensembl:ENSP00000340361	intact:EBI-2363776|uniprotkb:Q9UID1|uniprotkb:Q9UID2|ensembl:ENSP00000257868	psi-mi:avr2b_human(display_long)|uniprotkb:Activin receptor type IIB(gene name synonym)|uniprotkb:ACVR2B(gene name)|psi-mi:ACVR2B(display_short)	psi-mi:gdf11_human(display_long)|uniprotkb:GDF11(gene name)|psi-mi:GDF11(display_short)|uniprotkb:BMP11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499378|mint:MINT-8044205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097.2|ensembl:ENSG00000114739(gene)|ensembl:ENST00000352511(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2H62|rcsb pdb:2QLU|rcsb pdb:4FAO|rcsb pdb:5NGV|rcsb pdb:5NHR|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540|reactome:R-HSA-201451|mint:MINT-8044208(identity)	refseq:NP_005802.1|refseq:XP_006719257.1|ensembl:ENSG00000135414(gene)|ensembl:ENST00000257868(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:O95390|rcsb pdb:5E4G|rcsb pdb:5JHW|rcsb pdb:5UHM|rcsb pdb:6MAC|mint:MINT-8044212(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2d f2e f2f t2	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.8x10^-10(molar)	2010/10/08	2014/10/16	rogid:eMqaiRRH2Bb/PNBln8MaEt/JCBc9606	rogid:0UYBp3hPao/xUd6YGfgn05Pf/w49606	intact-crc:5D15FC23210CF164|rigid:c6w1BgZI68fYLI0HkdVMo/LvoBw	false	binding-associated region:19-137(MINT-8044209)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08689	uniprotkb:Q13705	intact:EBI-2366774|ensembl:ENSMUSP00000027269	intact:EBI-1383577|uniprotkb:Q4VAV0|ensembl:ENSP00000340361	psi-mi:gdf8_mouse(display_long)|uniprotkb:Mstn(gene name)|psi-mi:Mstn(display_short)|uniprotkb:Gdf8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:avr2b_human(display_long)|uniprotkb:Activin receptor type IIB(gene name synonym)|uniprotkb:ACVR2B(gene name)|psi-mi:ACVR2B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499361|mint:MINT-8044178	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034964.1|ensembl:ENSMUSG00000026100(gene)|ensembl:ENSMUST00000027269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3HH2|rcsb pdb:3SEK|rcsb pdb:5JI1|go:"GO:0045662"(negative regulation of myoblast differentiation)|mint:MINT-8044181(identity)	refseq:NP_001097.2|ensembl:ENSG00000114739(gene)|ensembl:ENST00000352511(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2H62|rcsb pdb:2QLU|rcsb pdb:4FAO|rcsb pdb:5NGV|rcsb pdb:5NHR|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540|reactome:R-HSA-201451|mint:MINT-8044180(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a f2b f2c t2	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.6x10^-9(molar)	2010/10/08	2014/10/16	rogid:x/AR38nYKdyVtykd0YgBsV2IXL010090	rogid:eMqaiRRH2Bb/PNBln8MaEt/JCBc9606	intact-crc:A93DABAB0607861E|rigid:m7tHrDyB/wZ9/q+PXYoqn3FouQM	false	-	binding-associated region:19-137(MINT-8044185)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEU8	uniprotkb:P01137	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499520|mint:MINT-8044312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|mint:MINT-8044317(identity)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936|mint:MINT-8044315(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1d t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-8(molar)	2010/10/08	2014/10/16	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	intact-crc:76628B01ADBAFD63|rigid:AyL1zZ4HkHWyfGFf7Bb+RU6bpCY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q8TEU8	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499532|mint:MINT-8044372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-8044377(identity)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|mint:MINT-8044375(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1f t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-8(molar)	2010/10/08	2014/10/16	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	intact-crc:9A972BA51BF83D92|rigid:owjx3OJ6ybbwHfCYIm9Dqenp8qw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12645	uniprotkb:Q8TEU8	intact:EBI-8464990|intact:MINT-8044327|uniprotkb:Q4VAS5|intact:EBI-8499308|ensembl:ENSP00000282701	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	psi-mi:bmp3_human(display_long)|uniprotkb:BMP3(gene name)|psi-mi:BMP3(display_short)|uniprotkb:BMP3A(gene name synonym)|uniprotkb:Bone morphogenetic protein 3A(gene name synonym)|uniprotkb:Osteogenin(gene name synonym)	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499544|mint:MINT-8044382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192.3|ensembl:ENSG00000152785(gene)|ensembl:ENST00000282701(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070700"(BMP receptor binding)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017197(Bone morphogenetic protein 3/growth differentiation factor 10)|interpro:IPR017948|interpro:IPR029034|mint:P12645|rcsb pdb:2QCQ|mint:MINT-8044387(identity)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|mint:MINT-8044385(identity)	-	comment:mint|comment:homomint	-	comment:homomint|comment:mint|figure legend:f1h t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-7(molar)	2010/10/08	2014/10/16	rogid:U1+lOcGUPg0aJVrJ0ttIgmvUfbw9606	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	intact-crc:D9636BA91B32E9FE|rigid:tQGEudfGc4XW+yjdo881F8RsPwE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36894	uniprotkb:P12644	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499504|mint:MINT-8044242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N|mint:MINT-8044245(identity)	refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development)|mint:MINT-8044249(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3b  f3d f3f t2	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-9(molar)	2010/10/08	2014/10/16	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606	intact-crc:FF81058C970FB40C|rigid:xxVhQnI2SMQvs/0uGEoRAUsJHPo	false	binding-associated region:24-152(MINT-8044246)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEU8	uniprotkb:P34820	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	intact:EBI-1752660|uniprotkb:E7EMY8|uniprotkb:Q32NE5|uniprotkb:Q53ZM7|uniprotkb:Q9NUF0|ensembl:ENSP00000361915	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:bmp8b_human(display_long)|uniprotkb:BMP8B(gene name)|psi-mi:BMP8B(display_short)|uniprotkb:BMP8(gene name synonym)|uniprotkb:Osteogenic protein 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499574|mint:MINT-8044393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|mint:MINT-8044396(identity)	refseq:NP_001711.2|ensembl:ENSG00000116985(gene)|ensembl:ENST00000372827(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0051216"(cartilage development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070700"(BMP receptor binding)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:MINT-8044398(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1j t1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.3x10^-5(molar)	2010/10/08	2014/10/16	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	rogid:AoeJiVsmENXITnhH/oX8oZXQwIk9606	intact-crc:23A0CF14872CFB54|rigid:64o/kkj6XzaWCF/4vgZI+TiGtlg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01137	uniprotkb:P37173	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Szláma et al. (2010)	pubmed:21054789|mint:MINT-8044119|mint:fj-10-0875.r1|doi:10.1111/j.1742-4658.2010.07909	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499593|mint:MINT-8044787	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936|mint:MINT-8044792(identity)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N|mint:MINT-8044790(identity)	-	-	-	figure legend:t2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-11(molar)	2010/10/08	2014/10/16	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	intact-crc:D05BB615A5C10968|rigid:WhjHlPrqcIIFOxZ3cQmEJypNHU4	false	-	binding-associated region:23-166(MINT-8044797)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)