#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62927	uniprotkb:O88900	intact:EBI-8417049|intact:MINT-8057701|uniprotkb:O08659	intact:EBI-7639197|intact:MINT-1347978	psi-mi:cnga1_rat(display_long)|uniprotkb:Cnga1(gene name)|psi-mi:Cnga1(display_short)|uniprotkb:Cncg(gene name synonym)|uniprotkb:Cncg1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)	psi-mi:grb14_rat(display_long)|uniprotkb:Grb14(gene name)|psi-mi:Grb14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417043|mint:MINT-8057729|imex:IM-15187-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032945|interpro:IPR032406|refseq:NP_445949.1|interpro:IPR005821(Ion transport)|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rgd:621815|interpro:IPR018490|reactome:R-RNO-2485179|reactome:R-RNO-2514859|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005221"(intracellular cyclic nucleotide activated cation channel activity)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0050896"(response to stimulus)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051899"(membrane depolarization)|mint:MINT-8057731(identity)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904145"(negative regulation of meiotic cell cycle process involved in oocyte maturation)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|rgd:61869|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_113811.1|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|reactome:R-RNO-210993|mint:MINT-8057732(identity)	go:"GO:0044317"(rod spherule)	comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	figure legend:f1a f1b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-retina)|taxid:10116(Rattus norvegicus)	-	2010/11/15	2014/10/16	rogid:9USp0kUl1gWA1aOtrTu+AFxlVHI10116	rogid:GMixEytYmFzuT6Kf3iYWl88a2xE10116	intact-crc:5307C710A1D34D6D|rigid:deUH1OPdVH1TrkhoX1uNfxHl1Kw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29973	uniprotkb:Q5ICW4	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	intact:EBI-7639273|intact:MINT-1348029	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417129|mint:MINT-8057739|imex:IM-15187-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057742(identity)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057744(identity)	-	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	figure legend:f3e|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	intact-crc:F56C0944FAF6B185|rigid:kfFaaf/6HbGwPIrhfxhEL2OLTU4	false	-	myc tag:?-?(MINT-8057751)|binding-associated region:105-195(MINT-8057753)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29973	uniprotkb:Q5ICW4	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	intact:EBI-7639273|intact:MINT-1348029	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417157|mint:MINT-8057757|imex:IM-15187-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057759(identity)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057761(identity)	-	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	figure legend:f5b|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	intact-crc:E9DC40E190725CDF|rigid:kfFaaf/6HbGwPIrhfxhEL2OLTU4	false	binding-associated region:483-690(MINT-8057774)|flag tag:?-?(MINT-8057772)	myc tag:?-?(MINT-8057765)|binding-associated region:105-195(MINT-8057762)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JLM9	uniprotkb:P29973	intact:EBI-8347358|intact:EBI-8417213|intact:MINT-4096749|uniprotkb:Q8VDI2|uniprotkb:Q9CR03|uniprotkb:Q3UI77|ensembl:ENSMUSP00000028252	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	psi-mi:grb14_mouse(display_long)|uniprotkb:Grb14(gene name)|psi-mi:Grb14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417207|mint:MINT-8057820|imex:IM-15187-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057928.1|ensembl:ENSMUSG00000026888(gene)|ensembl:ENSMUST00000028252(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904145"(negative regulation of meiotic cell cycle process involved in oocyte maturation)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q9JLM9|reactome:R-MMU-210993|mint:MINT-8057824(identity)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057822(identity)	-	comment:mint|function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	comment:homomint|comment:mint|figure legend:sf1e sf1f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:byYEu9h8uQcQRgOadTvQLEzTB5g10090	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	intact-crc:60658AF40C2028C9|rigid:QcAqgtiHhz47NB+k1oXIL0K9dyo	false	tag:?-?(MINT-8057828)	myc tag:?-?(MINT-8057834)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29973	uniprotkb:Q5ICW4	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	intact:EBI-7639273|intact:MINT-1348029	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417182|mint:MINT-8057778|imex:IM-15187-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057780(identity)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057786(identity)	-	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	figure legend:f5a|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	intact-crc:3D1D01981285287B|rigid:kfFaaf/6HbGwPIrhfxhEL2OLTU4	false	binding-associated region:483-690(MINT-8057781)|flag tag:?-?(MINT-8057783)	myc tag:?-?(MINT-8057790)|binding-associated region:105-195(MINT-8057787)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5ICW4	uniprotkb:Q14028	intact:EBI-7639273|intact:MINT-1348029	intact:EBI-7959609|uniprotkb:Q9UMG2|uniprotkb:O43636|intact:MINT-4853474|uniprotkb:Q14029|uniprotkb:Q13059|uniprotkb:H3BN09|ensembl:ENSP00000251102	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:cngb1_human(display_long)|uniprotkb:CNGB1(gene name)|psi-mi:CNGB1(display_short)|uniprotkb:CNCG2(gene name synonym)|uniprotkb:CNCG3L(gene name synonym)|uniprotkb:CNCG4(gene name synonym)|uniprotkb:RCNC2(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 4(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel modulatory subunit(gene name synonym)|uniprotkb:Glutamic acid-rich protein(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel gamma(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel beta-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417268|mint:MINT-8057853|imex:IM-15187-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057857(identity)	refseq:NP_001273059.1|refseq:NP_001129111.1|refseq:NP_001288.3|ensembl:ENSG00000070729(gene)|ensembl:ENST00000251102(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0021630"(olfactory nerve maturation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050911"(detection of chemical stimulus involved in sensory perception of smell)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0099105"(ion channel modulating, G protein-coupled receptor signaling pathway)|go:"GO:1902495"(transmembrane transporter complex)|go:"GO:1990834"(response to odorant)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032944|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-5620916|mint:MINT-8057855(identity)	-	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	comment:mint	comment:mint|figure legend:sf1i sf1j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	rogid:KZrL3SpqUeXWXzGZkZzdlLbo9N09606	intact-crc:921162BDBDD8D7D6|rigid:vDcQxKvlEvIoR3w3WvVwOjoLd+0	false	myc tag:?-?(MINT-8057861)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JLM9	uniprotkb:P29973	intact:EBI-8347358|intact:EBI-8417213|intact:MINT-4096749|uniprotkb:Q8VDI2|uniprotkb:Q9CR03|uniprotkb:Q3UI77|ensembl:ENSMUSP00000028252	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	psi-mi:grb14_mouse(display_long)|uniprotkb:Grb14(gene name)|psi-mi:Grb14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417250|mint:MINT-8057838|imex:IM-15187-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057928.1|ensembl:ENSMUSG00000026888(gene)|ensembl:ENSMUST00000028252(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904145"(negative regulation of meiotic cell cycle process involved in oocyte maturation)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q9JLM9|reactome:R-MMU-210993|mint:MINT-8057844(identity)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057840(identity)	-	comment:mint|function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	comment:homomint|comment:mint|figure legend:sf1g sf1h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/11/15	2014/10/16	rogid:byYEu9h8uQcQRgOadTvQLEzTB5g10090	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	intact-crc:86AB8940A8CA3C9F|rigid:QcAqgtiHhz47NB+k1oXIL0K9dyo	false	tag:?-?(MINT-8057845)	myc tag:?-?(MINT-8057841)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29973	uniprotkb:Q5ICW4	intact:EBI-8417095|uniprotkb:Q16485|intact:MINT-7004260|uniprotkb:Q16279|uniprotkb:A8K7K6|uniprotkb:Q4W5E3|uniprotkb:J3KPZ2|ensembl:ENSP00000384264|ensembl:ENSP00000389881|ensembl:ENSP00000426862	intact:EBI-7639273|intact:MINT-1348029	psi-mi:cnga1_human(display_long)|uniprotkb:CNGA1(gene name)|psi-mi:CNGA1(display_short)|uniprotkb:CNCG(gene name synonym)|uniprotkb:CNCG1(gene name synonym)|uniprotkb:Rod photoreceptor cGMP-gated channel subunit alpha(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel alpha-1(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel, photoreceptor(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 1(gene name synonym)	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417291|mint:MINT-8057797|imex:IM-15187-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011511925.1|refseq:NP_001136036.1|refseq:NP_000078.2|refseq:XP_016863201.1|ensembl:ENSG00000198515(gene)|ensembl:ENST00000402813(transcript)|ensembl:ENST00000420489(transcript)|ensembl:ENST00000514170(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0050896"(response to stimulus)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032406|interpro:IPR032945|rcsb pdb:7LFT|rcsb pdb:7LFW|rcsb pdb:7LFX|rcsb pdb:7LFY|rcsb pdb:7LG1|reactome:R-HSA-2485179|reactome:R-HSA-2514859|mint:MINT-8057799(identity)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057805(identity)	-	function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors|function:"Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"|comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	comment:domino|comment:mint|figure legend:f5c f5d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2010/11/15	2014/10/16	rogid:vb83vVdNJkzOGp8CUNMsf66JgyI9606	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	intact-crc:6C38F5E635436960|rigid:kfFaaf/6HbGwPIrhfxhEL2OLTU4	false	fusion protein:?-?(MINT-8057800)|binding-associated region:483-690(MINT-8057802)	fusion protein:?-?(MINT-8057806)|binding-associated region:105-195(MINT-8057808)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14028	uniprotkb:Q5ICW4	intact:EBI-7959609|uniprotkb:Q9UMG2|uniprotkb:O43636|intact:MINT-4853474|uniprotkb:Q14029|uniprotkb:Q13059|uniprotkb:H3BN09|ensembl:ENSP00000251102	intact:EBI-7639273|intact:MINT-1348029	psi-mi:cngb1_human(display_long)|uniprotkb:CNGB1(gene name)|psi-mi:CNGB1(display_short)|uniprotkb:CNCG2(gene name synonym)|uniprotkb:CNCG3L(gene name synonym)|uniprotkb:CNCG4(gene name synonym)|uniprotkb:RCNC2(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel 4(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel modulatory subunit(gene name synonym)|uniprotkb:Glutamic acid-rich protein(gene name synonym)|uniprotkb:Cyclic nucleotide-gated cation channel gamma(gene name synonym)|uniprotkb:Cyclic nucleotide-gated channel beta-1(gene name synonym)	psi-mi:grb14_bovin(display_long)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)|uniprotkb:GRB14 adapter protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gupta et al. (2010)	pubmed:20890309|imex:IM-15187|mint:MINT-8057694|doi:10.1038/embor.2010.142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8417316|mint:MINT-8057869|imex:IM-15187-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273059.1|refseq:NP_001129111.1|refseq:NP_001288.3|ensembl:ENSG00000070729(gene)|ensembl:ENST00000251102(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0017071"(intracellular cyclic nucleotide activated cation channel complex)|go:"GO:0021630"(olfactory nerve maturation)|go:"GO:0030552"(cAMP binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0050911"(detection of chemical stimulus involved in sensory perception of smell)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0099105"(ion channel modulating, G protein-coupled receptor signaling pathway)|go:"GO:1902495"(transmembrane transporter complex)|go:"GO:1990834"(response to odorant)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|interpro:IPR032944|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-5620916|mint:MINT-8057875(identity)	go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|refseq:NP_001011681.2|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:MINT-8057871(identity)	-	comment:mint	function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain|comment:mint	comment:mint|figure legend:sf1k sf1l|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2010/11/15	2014/10/16	rogid:KZrL3SpqUeXWXzGZkZzdlLbo9N09606	rogid:OyMjtInvufuj5LIiP3MQ8HPGL8g9913	intact-crc:A076D9CA73A97AA5|rigid:vDcQxKvlEvIoR3w3WvVwOjoLd+0	false	fusion protein:?-?(MINT-8057884)	fusion protein:?-?(MINT-8057872)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)