#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60486	uniprotkb:O75326	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927412|imex:IM-15164-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:3C310FE069A0CC8B|rigid:+zDd5AaAGS+99gjXo/xOuNT+bDs	false	his tag:c-c|sufficient binding region:35-507	sufficient binding region:45-634|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60486	uniprotkb:Q8JL80	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-2927425	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sema_ectvm(display_long)|uniprotkb:EVM139(gene name)|psi-mi:EVM139(display_short)|uniprotkb:SEMA(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:265874(ectvm)|taxid:265874("Ectromelia virus (strain Moscow)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927412|imex:IM-15164-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_671658.1|rcsb pdb:3NVN|interpro:IPR027231|interpro:IPR036352|rcsb pdb:6VXK	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:VVvBZwlE1hQjxsO/G2KMopYcVIw265874	intact-crc:3C310FE069A0CC8B|rigid:+zDd5AaAGS+99gjXo/xOuNT+bDs	false	his tag:c-c|sufficient binding region:35-507	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60486	uniprotkb:O75326	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927441|imex:IM-15164-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:3FA91902E2986356|rigid:os7NXVDELq6qxzE/E6iGPVawPgk	false	his tag:c-c|sufficient binding region:35-507	sufficient binding region:1-648|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60486	uniprotkb:O75326	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927441|imex:IM-15164-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:3FA91902E2986356|rigid:os7NXVDELq6qxzE/E6iGPVawPgk	false	his tag:c-c|sufficient binding region:35-507	sufficient binding region:45-634|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60486	uniprotkb:O75326	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927460|imex:IM-15164-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:62156AEEE506E95C|rigid:os7NXVDELq6qxzE/E6iGPVawPgk	false	his tag:c-c|sufficient binding region:1-944	sufficient binding region:1-648|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8JL80	uniprotkb:O60486	intact:EBI-2927425	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	psi-mi:sema_ectvm(display_long)|uniprotkb:EVM139(gene name)|psi-mi:EVM139(display_short)|uniprotkb:SEMA(gene name synonym)	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:265874(ectvm)|taxid:265874("Ectromelia virus (strain Moscow)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927474|imex:IM-15164-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_671658.1|rcsb pdb:3NVN|interpro:IPR027231|interpro:IPR036352|rcsb pdb:6VXK	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|kinetic_conditions:Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:VVvBZwlE1hQjxsO/G2KMopYcVIw265874	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	intact-crc:CF137B223F93BAB1|rigid:4WFgbBTUtijk5Cg99IfBunbADA0	false	his tag:c-c	his tag:c-c|sufficient binding region:1-944	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75326	uniprotkb:O75326	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927545|imex:IM-15164-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	go:"GO:0042803"(protein homodimerization activity)	-	-	comment:N-linked glycans have been removed prior to purification.|figure legend:Supp. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:0F2E7AE4A6E6A1BF|rigid:5NLAcrCU0i/q07m1/jFgHTJ38fA	false	sufficient binding region:1-648|his tag:c-c	sufficient binding region:1-648|his tag:c-c	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8JL80	uniprotkb:Q8JL80	intact:EBI-2927425	intact:EBI-2927425	psi-mi:sema_ectvm(display_long)|uniprotkb:EVM139(gene name)|psi-mi:EVM139(display_short)|uniprotkb:SEMA(gene name synonym)	psi-mi:sema_ectvm(display_long)|uniprotkb:EVM139(gene name)|psi-mi:EVM139(display_short)|uniprotkb:SEMA(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:265874(ectvm)|taxid:265874("Ectromelia virus (strain Moscow)")	taxid:265874(ectvm)|taxid:265874("Ectromelia virus (strain Moscow)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927553|imex:IM-15164-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_671658.1|rcsb pdb:3NVN|interpro:IPR027231|interpro:IPR036352|rcsb pdb:6VXK	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_671658.1|rcsb pdb:3NVN|interpro:IPR027231|interpro:IPR036352|rcsb pdb:6VXK	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:Supp. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:VVvBZwlE1hQjxsO/G2KMopYcVIw265874	rogid:VVvBZwlE1hQjxsO/G2KMopYcVIw265874	intact-crc:79579F5ED5B29130|rigid:FtVPFgU+D1XZ8rt0AzSIGsslw2I	false	his tag:c-c	his tag:c-c	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O60486	uniprotkb:Q8JL80	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-2927425	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sema_ectvm(display_long)|uniprotkb:EVM139(gene name)|psi-mi:EVM139(display_short)|uniprotkb:SEMA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:265874(ectvm)|taxid:265874("Ectromelia virus (strain Moscow)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927566|wwpdb:3nvn|imex:IM-15164-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_671658.1|rcsb pdb:3NVN|interpro:IPR027231|interpro:IPR036352|rcsb pdb:6VXK	-	-	-	figure legend:Supp. Table 1|3d-resolution:2.3A|3d-r-factors:"R-working:23.9% R-free:27.6%"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:VVvBZwlE1hQjxsO/G2KMopYcVIw265874	intact-crc:44DB99952A456002|rigid:4WFgbBTUtijk5Cg99IfBunbADA0	false	his tag:c-c|sufficient binding region:35-507	his tag:c-c|sufficient binding region:15-399	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60486	uniprotkb:O75326	intact:EBI-2927384|ensembl:ENSP00000258526|uniprotkb:Q59H25	intact:EBI-1753538|uniprotkb:Q1XE81|uniprotkb:Q1XE82|uniprotkb:Q1XE83|uniprotkb:Q1XE84|uniprotkb:Q3MIY5|uniprotkb:B4DDP7|uniprotkb:F5H1S0|ensembl:ENSP00000261918|ensembl:ENSP00000500448	psi-mi:plxc1_human(display_long)|uniprotkb:PLXNC1(gene name)|psi-mi:PLXNC1(display_short)|uniprotkb:VESPR(gene name synonym)|uniprotkb:Virus-encoded semaphorin protein receptor(gene name synonym)	psi-mi:sem7a_human(display_long)|uniprotkb:SEMA7A(gene name)|psi-mi:SEMA7A(display_short)|uniprotkb:CD108(gene name synonym)|uniprotkb:SEMAL(gene name synonym)|uniprotkb:Semaphorin-L(gene name synonym)|uniprotkb:Semaphorin-K1(gene name synonym)|uniprotkb:John-Milton-Hargen human blood group Ag(gene name synonym)|uniprotkb:JMH blood group antigen(gene name synonym)|uniprotkb:CDw108(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927590|wwpdb:3nvq|imex:IM-15164-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136040(gene)|ensembl:ENST00000258526(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041853|rcsb pdb:3KUZ|rcsb pdb:3NVN|rcsb pdb:3NVQ|rcsb pdb:6VXK|reactome:R-HSA-416700|go:"GO:0050772"(positive regulation of axonogenesis)|refseq:NP_005752.1	refseq:NP_001139501.1|refseq:NP_003603.1|refseq:NP_001139502.1|ensembl:ENSG00000138623(gene)|ensembl:ENSG00000288455(gene)|ensembl:ENST00000261918(transcript)|ensembl:ENST00000671713(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048675"(axon extension)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042824|mint:O75326|rcsb pdb:3NVQ|reactome:R-HSA-416700	-	-	-	figure legend:Supp. Table 1|3d-resolution:2.14A|3d-r-factors:"R-working:24.8% R-free:27.7%"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:6FU1DXa/LFEiQfKZJEcg2qjjLxA9606	rogid:jvLJrmoDZPhZAxms3wWXHescQas9606	intact-crc:393061700EA0A10C|rigid:os7NXVDELq6qxzE/E6iGPVawPgk	false	his tag:c-c|sufficient binding region:35-507	sufficient binding region:45-634|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21062	uniprotkb:P21062	intact:EBI-2927610	intact:EBI-2927610	psi-mi:sema_vaccc(display_long)|uniprotkb:A39R(orf name)	psi-mi:sema_vaccc(display_long)|uniprotkb:A39R(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Liu et al. (2010)	pubmed:20727575|imex:IM-15164	taxid:10249(vaccc)|taxid:10249("Vaccinia virus (strain Copenhagen) (VACV)")	taxid:10249(vaccc)|taxid:10249("Vaccinia virus (strain Copenhagen) (VACV)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927616|imex:IM-15164-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3NVX|interpro:IPR027231|interpro:IPR036352	go:"GO:0005576"(extracellular region)|go:"GO:0030215"(semaphorin receptor binding)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR015943(WD40/YVTN repeat-like)|rcsb pdb:3NVX|interpro:IPR027231|interpro:IPR036352	psi-mi:"MI:0469"(intact)	-	-	3d-resolution:2.3A|3d-r-factors:"R-working:23.9% R-free:27.6%"|figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:05sljJ2zXpLWjY+/82Mx0zZz/Ek10249	rogid:05sljJ2zXpLWjY+/82Mx0zZz/Ek10249	intact-crc:7ACDE24EF77BE41E|rigid:ncipKztHjChCMZPLaxeBegjGl7s	false	sufficient binding region:15-399(IPR001627)	sufficient binding region:15-399(IPR001627)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)