#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7KLI1	uniprotkb:Q9XYF4	intact:EBI-3404349|ensemblmetazoa:FBpp0086122	intact:EBI-108311|ensemblmetazoa:FBpp0076076	psi-mi:q7kli1_drome(display_long)|uniprotkb:Dark(gene name)|psi-mi:Dark(display_short)|uniprotkb:Ark(gene name synonym)|uniprotkb:Ark-RB(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:dapaf-1L(gene name synonym)|uniprotkb:APAF-1(gene name synonym)|uniprotkb:APAF1(gene name synonym)|uniprotkb:ARK(gene name synonym)|uniprotkb:Apaf-1(gene name synonym)|uniprotkb:Apaf-I(gene name synonym)|uniprotkb:Apaf1(gene name synonym)|uniprotkb:D-Apaf-1(gene name synonym)|uniprotkb:DARK(gene name synonym)|uniprotkb:Dapaf-1(gene name synonym)|uniprotkb:Dmel\CG6829(gene name synonym)|uniprotkb:HAC-1(gene name synonym)|uniprotkb:HAC1(gene name synonym)|uniprotkb:Hac-1(gene name synonym)|uniprotkb:T1(gene name synonym)|uniprotkb:anon-53Fa(gene name synonym)|uniprotkb:apaf-1(gene name synonym)|uniprotkb:apaf1(gene name synonym)|uniprotkb:arc(gene name synonym)|uniprotkb:ark(gene name synonym)|uniprotkb:dAPAF-1(gene name synonym)|uniprotkb:dApaf-1(gene name synonym)|uniprotkb:dApaf1(gene name synonym)|uniprotkb:dArk(gene name synonym)|uniprotkb:dapaf(gene name synonym)|uniprotkb:dapaf-1(gene name synonym)|uniprotkb:dapaf-1S(gene name synonym)|uniprotkb:dark(gene name synonym)|uniprotkb:hac-1(gene name synonym)|uniprotkb:hac1(gene name synonym)|uniprotkb:"l(2)SH0173"(gene name synonym)|uniprotkb:CG6829(orf name)|uniprotkb:Dmel_CG6829(orf name)|uniprotkb:Apaf(gene name synonym)	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2010)	pubmed:20700104|imex:IM-15131|mint:MINT-8048652|doi:10.1038/emboj.2010.191	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8155874|mint:MINT-8048722|imex:IM-15131-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0263864(gene)|ensemblmetazoa:FBtr0086968(transcript)|go:"GO:0002921"(negative regulation of humoral immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0012501"(programmed cell death)|go:"GO:0021556"(central nervous system formation)|go:"GO:0022416"(chaeta development)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043531"(ADP binding)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:1901053"(sarcosine catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR002182(NB-ARC)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR027417|interpro:IPR036322|interpro:IPR036388|rcsb pdb:3J9K|rcsb pdb:3J9L|rcsb pdb:4V4L|rcsb pdb:5JUL|flybase:FBgn0263864|refseq:NP_725637.1|mint:MINT-8048725(identity)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836|mint:MINT-8048724(identity)	-	-	-	figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/10/19	2014/10/16	rogid:oX7ecezYeP4wxL1mtHP4lvmzEtY7227	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	intact-crc:B326DCE425C5CFCA|rigid:39MR9SgQ+PsRHwkukDAvbsTTI0U	false	flag tag:?-?(MINT-8048735)|binding-associated region:1-411(MINT-8048738)	mutation increasing interaction:318-318(MINT-8048745)|mutation increasing interaction:130-130(MINT-8048748)|ha tag:?-?(MINT-8048742)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9XYF4	uniprotkb:Q24306	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yang et al. (2010)	pubmed:20700104|imex:IM-15131|mint:MINT-8048652|doi:10.1038/emboj.2010.191	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8155930|mint:MINT-8048752|imex:IM-15131-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836|mint:MINT-8048754(identity)	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751|mint:MINT-8048762(identity)	-	-	-	figure legend:sf6|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/10/19	2014/10/16	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:8090230AD273306C|rigid:qalCjviB3SHZ6V5+m8m9iok9OG8	false	ha tag:?-?(MINT-8048759)	flag tag:?-?(MINT-8048765)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9XYF4	uniprotkb:Q00168	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Yang et al. (2010)	pubmed:20700104|imex:IM-15131|mint:MINT-8048652|doi:10.1038/emboj.2010.191	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8155983|mint:MINT-8048772|imex:IM-15131-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836|mint:MINT-8048774(identity)	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837|mint:MINT-8048778(identity)	-	-	-	figure legend:f5d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/19	2014/10/16	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:5F16C1FA5325DD18|rigid:nuoWGscahooLeidhGla5abGzekM	false	phosphorylated residue:130-130(MINT-8048786)|mutation disrupting interaction:130-130(MINT-8048788)|glutathione s tranferase tag:?-?(MINT-8048775)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O01382	uniprotkb:Q9XYF4	intact:EBI-91422|uniprotkb:Q9VAH1|ensemblmetazoa:FBpp0084848	intact:EBI-108311|ensemblmetazoa:FBpp0076076	psi-mi:drice_drome(display_long)|uniprotkb:drICE(gene name synonym)|uniprotkb:CG7788(orf name)|uniprotkb:Drice(gene name)|psi-mi:Drice(display_short)|uniprotkb:ICE(gene name synonym)	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:"MI:0435"(protease assay)	Yang et al. (2010)	pubmed:20700104|imex:IM-15131|mint:MINT-8048652|doi:10.1038/emboj.2010.191	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8156042|mint:MINT-8048792|imex:IM-15131-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524551.2|flybase:FBgn0019972|ensemblmetazoa:FBgn0019972(gene)|ensemblmetazoa:FBtr0085482(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0010165"(response to X-ray)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035103"(sterol regulatory element binding protein cleavage)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1990525"(BIR domain binding)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:3SIP|rcsb pdb:3SIR|reactome:R-DME-111465|reactome:R-DME-264870|reactome:R-DME-75153|dip:DIP-21838N|mint:MINT-8048794(identity)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836|mint:MINT-8048796(identity)	-	-	-	figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/19	2014/10/16	rogid:aJREbCpkH2DICPbhBY7VVZe4qx07227	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	intact-crc:B973C30A22D89EA1|rigid:TzFN2iNNNY5xCDD1OzZuseh12Hk	false	-	glutathione s tranferase tag:?-?(MINT-8048801)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)