#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75147	uniprotkb:Q8WZ42	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984019|mint:MINT-7979611|imex:IM-15061-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979614(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979613(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:t1 f2 sf5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/15	2014/10/16	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:B7E8222D8D4B3B56|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:1-105(MINT-7979624)	binding-associated region:34253-34350(MINT-7979618)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984050|mint:MINT-7979665|imex:IM-15061-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979672(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979667(identity)	-	-	-	figure legend:sf2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:6CC502181CB58B67|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	tag:?-?(MINT-7979680)|binding-associated region:1-103(MINT-7979673)	binding-associated region:34253-34350(MINT-7979668)|tag:?-?(MINT-7979683)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O75147	uniprotkb:Q8WZ42	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984077|mint:MINT-7979686|imex:IM-15061-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979695(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979688(identity)	-	-	-	figure legend:sf2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/15	2014/10/16	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:4CB865982628049D|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:1-105(MINT-7979698)|tag:?-?(MINT-7979696)	tag:?-?(MINT-7979689)|binding-associated region:34253-34350(MINT-7979691)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q8WZ42	uniprotkb:O75147	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984113|mint:MINT-7979631|imex:IM-15061-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979633(identity)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979638(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf1a sf1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/15	2014/10/16	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	intact-crc:3E52DE0F8580C864|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:34253-34350(MINT-7979634)	binding-associated region:1-105(MINT-7979639)	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984134|mint:MINT-7979650|imex:IM-15061-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979657(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979652(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf1b sf1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:62F91BCD9DA2AC67|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979658)	binding-associated region:34253-34350(MINT-7979653)	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8WZ42	uniprotkb:O75147	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984186|mint:MINT-7979729|imex:IM-15061-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979732(identity)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979737(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.92x10^-6(molar)	2010/07/15	2014/10/16	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	intact-crc:E2CF828A50DDBCA1|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:34253-34350(MINT-7979733)|mutation increasing interaction:34348-34348(MINT-7979744)	binding-associated region:1-105(MINT-7979738)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WZ42	uniprotkb:O75147	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984164|mint:MINT-7979704|imex:IM-15061-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979706(identity)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979713(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3a t2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2010/07/15	2014/10/16	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	intact-crc:C8389370249179C6|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:34253-34350(MINT-7979707)	binding-associated region:1-105(MINT-7979714)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WZ42	uniprotkb:O75147	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984229|mint:MINT-7979747|imex:IM-15061-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979750(identity)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979757(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:28.5x10^-6(molar)	2010/07/15	2014/10/16	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	intact-crc:DFF6239CB3986268|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:34253-34350(MINT-7979753)|mutation decreasing interaction:34311-34311(MINT-7979751)	binding-associated region:1-105(MINT-7979758)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WZ42	uniprotkb:O75147	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984255|mint:MINT-7979766|imex:IM-15061-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979769(identity)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979776(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2010/07/15	2014/10/16	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	intact-crc:5EF067DCFFDDDFDC|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	mutation decreasing interaction:34302-34302(MINT-7979773)|binding-associated region:34253-34350(MINT-7979770)	binding-associated region:1-105(MINT-7979777)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984345|mint:MINT-7979808|imex:IM-15061-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979818(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979811(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.6x10^-6(molar)	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:A4BAF11A644BD1A7|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979819)	mutation decreasing interaction:34303-34303(MINT-7979815)|binding-associated region:34253-34350(MINT-7979812)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75147	uniprotkb:Q8WZ42	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984281|mint:MINT-7979789|imex:IM-15061-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664|mint:MINT-7979799(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979792(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.5x10^-6(molar)	2010/07/15	2014/10/16	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:0F32E59D04B7928B|rigid:TqClA5zINXi3g9owo/iJMg3od90	false	binding-associated region:1-105(MINT-7979800)	binding-associated region:34253-34350(MINT-7979795)|mutation decreasing interaction:34303-34303(MINT-7979793)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984446|mint:MINT-7979844|imex:IM-15061-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979854(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979847(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-6(molar)	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:CAD647F54AF99A1C|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979855)	binding-associated region:34253-34350(MINT-7979848)|mutation decreasing interaction:34311-34311(MINT-7979851)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984371|mint:MINT-7979826|imex:IM-15061-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979836(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979829(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.4x10^-6(molar)	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:8066C4774582109A|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979837)	mutation decreasing interaction:34302-34302(MINT-7979830)|binding-associated region:34253-34350(MINT-7979832)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984490|mint:MINT-7979863|imex:IM-15061-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979873(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979866(identity)	-	-	-	figure legend:t2|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.22x10^-6(molar)	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:C06C7511BCD8BC0D|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979874)	mutation decreasing interaction:34348-34348(MINT-7979867)|binding-associated region:34253-34350(MINT-7979869)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5VST9	uniprotkb:Q8WZ42	intact:EBI-941850|uniprotkb:Q2A664|uniprotkb:Q5T7G8|uniprotkb:Q5T7G9|uniprotkb:Q5VSU2|uniprotkb:Q86YC7|uniprotkb:Q8NHN0|uniprotkb:Q8NHN1|uniprotkb:Q8NHN2|uniprotkb:Q8NHN3|uniprotkb:Q8NHN4|uniprotkb:Q8NHN5|uniprotkb:Q8NHN6|uniprotkb:Q8NHN7|uniprotkb:Q8NHN8|uniprotkb:Q8NHN9|uniprotkb:Q96AA2|uniprotkb:Q9HCD3|uniprotkb:Q9HCL6|ensembl:ENSP00000409493	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:obscn_human(display_long)|uniprotkb:OBSCN(gene name)|psi-mi:OBSCN(display_short)|uniprotkb:KIAA1639(gene name synonym)|uniprotkb:Obscurin-myosin light chain kinase(gene name synonym)|uniprotkb:Obscurin-RhoGEF(gene name synonym)|uniprotkb:KIAA1556(gene name synonym)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sauer et al. (2010)	pubmed:20489725|imex:IM-15061|mint:MINT-7979563|doi:10.1038/embor.2010.65	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7984528|mint:MINT-7979881|imex:IM-15061-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000284548|ensembl:ENSP00000284548|ensembl:ENSP00000409493|ensembl:ENST00000636476|ensembl:ENSP00000489816|ensembl:ENST00000662438|ensembl:ENSP00000499633|refseq:NP_001092093.2|refseq:NP_443075.3|dip:DIP-35727N|ensembl:ENSG00000154358(gene)|ensembl:ENST00000422127(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0031432"(titin binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0036309"(protein localization to M-band)|go:"GO:0042383"(sarcolemma)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020682|interpro:IPR035526|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1V1C|rcsb pdb:2CR6|rcsb pdb:2DKU|rcsb pdb:2DM7|rcsb pdb:2E7B|rcsb pdb:2EDF|rcsb pdb:2EDH|rcsb pdb:2EDL|rcsb pdb:2EDQ|rcsb pdb:2EDR|rcsb pdb:2EDT|rcsb pdb:2EDW|rcsb pdb:2ENY|rcsb pdb:2EO1|rcsb pdb:2GQH|rcsb pdb:2MWC|rcsb pdb:2N56|rcsb pdb:2YZ8|rcsb pdb:4C4K|rcsb pdb:4RSV|rcsb pdb:4UOW|rcsb pdb:5TZM|rcsb pdb:6MG9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013406|mint:MINT-7979891(identity)	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N|mint:MINT-7979884(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:t2 sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.16x10^-6(molar)	2010/07/15	2014/10/16	rogid:pUzPNEELWyEtZa4+ra9kGoGMntc9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:B7EEC160002FB216|rigid:AgzQUMkdqxzd6jiRILwsZ/eSrYg	false	binding-associated region:1-103(MINT-7979892)	binding-associated region:34253-34350(MINT-7979885)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)