#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99490-2 uniprotkb:Q08501 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-7737664|ensembl:ENSMUSP00000122219|uniprotkb:Q62099|intact:MINT-4596793|uniprotkb:P15212|uniprotkb:P15213 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:prlr_mouse(display_long)|uniprotkb:Prlr(gene name)|psi-mi:Prlr(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737658|mint:MINT-7722187|imex:IM-15467-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7722189(identity) ensembl:ENSMUSG00000005268(gene)|ensembl:ENSMUST00000124470(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004925"(prolactin receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR033230|interpro:IPR036116|reactome:R-MMU-1170546|reactome:R-MMU-982772|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001240711.1|refseq:NP_035299.4|refseq:XP_006520097.1|refseq:XP_006520098.1|refseq:XP_006520099.1|refseq:XP_006520100.1|refseq:XP_006520101.1|mint:MINT-7722190(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. comment:mint|function:This is a receptor for the anterior pituitary hormone prolactin figure legend:f1g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:PPL8kEkl0U8ygigkaqlpQil/dOE10090 intact-crc:36692EF91905A350|rigid:dPEHPpWQh+YpQWYEFTprmicT234 false glutathione s tranferase tag:?-?(MINT-7722198) binding-associated region:486-608(MINT-7722195)|green fluorescent protein tag:?-?(MINT-7722192) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99490-2 uniprotkb:P42229 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737729|mint:MINT-7760966|imex:IM-15467-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7760968(identity) refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-7760970(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606 intact-crc:A9FA805DBBCF51EE|rigid:sa5ms8YEx/sdSavjqcYSC2IJpMU false glutathione s tranferase tag:?-?(MINT-7760975) green fluorescent protein tag:?-?(MINT-7760971) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P42229 uniprotkb:P14753 intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449 intact:EBI-617901|ensembl:ENSMUSP00000006397|uniprotkb:Q63852 psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym) psi-mi:epor_mouse(display_long)|uniprotkb:Epor(gene name)|psi-mi:Epor(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737786|mint:MINT-7891339|imex:IM-15467-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-7891345(identity) reactome:R-MMU-9027276|reactome:R-MMU-9027284|rcsb pdb:2MXB|ensembl:ENSMUSG00000006235(gene)|ensembl:ENSMUST00000006397(transcript)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004900"(erythropoietin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0046697"(decidualization)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR009167(Erythropoietin receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|mint:P14753|refseq:NP_034279.3|dip:DIP-657N|mint:MINT-7891341(identity) - - - comment:homomint|comment:mint|figure legend:f1h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/04/08 2014/10/16 rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606 rogid:UIMmftITb7Wp1qd5cqrkS9XFR3Q10090 intact-crc:59EB08121B2FF646|rigid:nwzq++hjQKuZsfWtsOUZmwA18Gc false green fluorescent protein tag:?-?(MINT-7891346) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99490-2 uniprotkb:P42230 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737747|mint:MINT-7760998|imex:IM-15467-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7761001(identity) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-7761000(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. - figure legend:f1e|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:A95FE4777F7FCC3A|rigid:ICC63PQ4z2BZirRqA6dZ7fQio24 false green fluorescent protein tag:?-?(MINT-7761010) binding-associated region:330-496(MINT-7761006)|myc tag:?-?(MINT-7761003) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P42230 uniprotkb:Q3UHD9 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 intact:EBI-771911|uniprotkb:Q5DU45|ensembl:ENSMUSP00000043466 psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:agap2_mouse(display_long)|uniprotkb:Agap2(gene name)|psi-mi:Agap2(display_short)|uniprotkb:Centg1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:Kiaa0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737830|mint:MINT-7722213|imex:IM-15467-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-7722215(identity) refseq:NP_001028435.1|refseq:NP_001287943.1|ensembl:ENSMUSG00000025422(gene)|ensembl:ENSMUST00000039259(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0090543"(Flemming body)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|go:"GO:0005768"(endosome)|mint:MINT-7722219(identity) - - - figure legend:f6d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mammary gland)|taxid:10090(Mus musculus mammary gland) - 2010/04/08 2014/10/16 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 rogid:yq2lQtfk+FPqgT++CxAx2CS69nE10090 intact-crc:06398C4562C1F36B|rigid:hWvX31g1O2E/8dMYdPtDCB5vNNc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q08501 uniprotkb:P42230 intact:EBI-7737664|ensembl:ENSMUSP00000122219|uniprotkb:Q62099|intact:MINT-4596793|uniprotkb:P15212|uniprotkb:P15213 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:prlr_mouse(display_long)|uniprotkb:Prlr(gene name)|psi-mi:Prlr(display_short) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737841|mint:MINT-7722224|imex:IM-15467-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000005268(gene)|ensembl:ENSMUST00000124470(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004925"(prolactin receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR033230|interpro:IPR036116|reactome:R-MMU-1170546|reactome:R-MMU-982772|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001240711.1|refseq:NP_035299.4|refseq:XP_006520097.1|refseq:XP_006520098.1|refseq:XP_006520099.1|refseq:XP_006520100.1|refseq:XP_006520101.1|mint:MINT-7722226(identity) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-7722227(identity) - comment:mint|function:This is a receptor for the anterior pituitary hormone prolactin - figure legend:f6d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-mammary gland)|taxid:10090(Mus musculus mammary gland) - 2010/04/08 2014/10/16 rogid:PPL8kEkl0U8ygigkaqlpQil/dOE10090 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:DCE9B9AEF1D2B0CA|rigid:1sJdCuESkZcxk75Hm7U+rViPnTo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99490-2 uniprotkb:P42229 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym) psi-mi:"MI:0096"(pull down) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737861|mint:MINT-7760983|imex:IM-15467-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7760985(identity) refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-7760986(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. - figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606 intact-crc:7C374DAB1F8D8D81|rigid:sa5ms8YEx/sdSavjqcYSC2IJpMU false glutathione s tranferase tag:?-?(MINT-7760988)|binding-associated region:1-72(MINT-7760991) green fluorescent protein tag:?-?(MINT-7760994) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99490-2 uniprotkb:P42230 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737928|mint:MINT-7761019|imex:IM-15467-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7761021(identity) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-7761022(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. - figure legend:f2a f2c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-hc11)|taxid:10090(Mus musculus) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:E01A18E8981E390E|rigid:ICC63PQ4z2BZirRqA6dZ7fQio24 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99490-2 uniprotkb:Q08501 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-7737664|ensembl:ENSMUSP00000122219|uniprotkb:Q62099|intact:MINT-4596793|uniprotkb:P15212|uniprotkb:P15213 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:prlr_mouse(display_long)|uniprotkb:Prlr(gene name)|psi-mi:Prlr(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7737940|mint:MINT-7761029|imex:IM-15467-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7761032(identity) ensembl:ENSMUSG00000005268(gene)|ensembl:ENSMUST00000124470(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004925"(prolactin receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR033230|interpro:IPR036116|reactome:R-MMU-1170546|reactome:R-MMU-982772|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001240711.1|refseq:NP_035299.4|refseq:XP_006520097.1|refseq:XP_006520098.1|refseq:XP_006520099.1|refseq:XP_006520100.1|refseq:XP_006520101.1|mint:MINT-7761031(identity) - comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. comment:mint|function:This is a receptor for the anterior pituitary hormone prolactin comment:homomint|comment:mint|figure legend:f2a f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-hc11)|taxid:10090(Mus musculus) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:PPL8kEkl0U8ygigkaqlpQil/dOE10090 intact-crc:C59C01F483DFB256|rigid:dPEHPpWQh+YpQWYEFTprmicT234 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99490-2 uniprotkb:P42229 intact:EBI-7737644|intact:MINT-4090615|ensembl:ENSP00000257897 intact:EBI-749537|uniprotkb:Q1KLZ6|ensembl:ENSP00000341208|ensembl:ENSP00000468749|ensembl:ENSP00000503262|ensembl:ENSP00000504449 psi-mi:q99490-2(display_long)|uniprotkb:AGAP2(gene name)|psi-mi:AGAP2(display_short)|uniprotkb:CENTG1(gene name synonym)|uniprotkb:Centaurin-gamma-1(gene name synonym)|uniprotkb:GTP-binding and GTPase-activating protein 2(gene name synonym)|uniprotkb:KIAA0167(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase enhancer(gene name synonym)|uniprotkb:PIKE-A(isoform synonym) psi-mi:sta5a_human(display_long)|uniprotkb:STAT5A(gene name)|psi-mi:STAT5A(display_short)|uniprotkb:STAT5(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Chan et al. (2010) pubmed:20075866|imex:IM-15467|mint:MINT-7722179|doi:10.1038/emboj.2009.406 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7737987|mint:MINT-7761049|imex:IM-15467-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2361824(isoform-parent)|ensembl:ENSG00000135439(gene)|ensembl:ENST00000257897(transcript)|mint:MINT-7761051(identity) refseq:NP_003143.2|refseq:NP_001275647.1|refseq:NP_001275648.1|refseq:NP_001275649.1|dip:DIP-396N|ensembl:ENSG00000126561(gene)|ensembl:ENST00000345506(transcript)|ensembl:ENST00000590949(transcript)|ensembl:ENST00000676585(transcript)|ensembl:ENST00000677301(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007595"(lactation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42229|reactome:R-HSA-1170546|reactome:R-HSA-1251985|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-2586552|reactome:R-HSA-512988|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020958|reactome:R-HSA-9027283|reactome:R-HSA-9645135|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9705462|reactome:R-HSA-982772|mint:MINT-7761052(identity) go:"GO:0005737"(cytoplasm) comment:mint|isoform-comment:Contains a phosphotyrosine at position 682. Contains a phosphotyrosine at position 774. - figure legend:f2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-hc11)|taxid:10090(Mus musculus) - 2010/04/08 2014/10/16 rogid:P4g2Ug/hXz9nHVHKkXn2NvqJiiw9606 rogid:KwM9uGM/He9Ome/Pzi6u/SgC6NY9606 intact-crc:644B2E55CA00FF11|rigid:sa5ms8YEx/sdSavjqcYSC2IJpMU false myc tag:?-?(MINT-7761055) green fluorescent protein tag:?-?(MINT-7761059) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0396"(predetermined participant)