#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9VVX3	uniprotkb:Q9W450	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	intact:EBI-149374|uniprotkb:Q9W449|ensemblmetazoa:FBpp0070830	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:q9w450_drome(display_long)|uniprotkb:Grip(gene name)|psi-mi:Grip(display_short)|uniprotkb:Grip-RA(gene name synonym)|uniprotkb:DGrip(gene name synonym)|uniprotkb:Dgrip(gene name synonym)|uniprotkb:Dmel\CG14447(gene name synonym)|uniprotkb:GRIP(gene name synonym)|uniprotkb:dGRIP(gene name synonym)|uniprotkb:dgrip(gene name synonym)|uniprotkb:grip(gene name synonym)|uniprotkb:Dmel_CG14447(orf name)|uniprotkb:CG14447(orf name)|uniprotkb:CG5980(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ataman et al. (2006)	pubmed:16682643|imex:IM-23504	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-2547895|imex:IM-23504-1|dip:DIP-141063E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	refseq:NP_572285.2|flybase:FBgn0029830|dip:DIP-21613N|ensemblmetazoa:FBgn0029830(gene)|ensemblmetazoa:FBtr0070865(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005912"(adherens junction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016203"(muscle attachment)|go:"GO:0016204"(determination of muscle attachment site)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q9W450|reactome:R-DME-438066|reactome:R-DME-451308|reactome:R-DME-8849932|reactome:R-DME-6794361	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig. 6. F and Fig. 6. G|delivery method:Q9W450;A8JNV7 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/01/26	2017/06/30	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rogid:Vac41Jh2XszZRaJMe+6fsn0HyKU7227	intact-crc:A05166220663E987|rigid:c+1n1Hh7lkNAgsN/r0AmKP9Rpfg	false	myc tag:?-?	sufficient binding region:431-747(IPR001478)|v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VVX3	uniprotkb:Q9W450	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	intact:EBI-149374|uniprotkb:Q9W449|ensemblmetazoa:FBpp0070830	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:q9w450_drome(display_long)|uniprotkb:Grip(gene name)|psi-mi:Grip(display_short)|uniprotkb:Grip-RA(gene name synonym)|uniprotkb:DGrip(gene name synonym)|uniprotkb:Dgrip(gene name synonym)|uniprotkb:Dmel\CG14447(gene name synonym)|uniprotkb:GRIP(gene name synonym)|uniprotkb:dGRIP(gene name synonym)|uniprotkb:dgrip(gene name synonym)|uniprotkb:grip(gene name synonym)|uniprotkb:Dmel_CG14447(orf name)|uniprotkb:CG14447(orf name)|uniprotkb:CG5980(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ataman et al. (2006)	pubmed:16682643|imex:IM-23504	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-2548669|dip:DIP-141063E|imex:IM-23504-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	refseq:NP_572285.2|flybase:FBgn0029830|dip:DIP-21613N|ensemblmetazoa:FBgn0029830(gene)|ensemblmetazoa:FBtr0070865(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005912"(adherens junction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016203"(muscle attachment)|go:"GO:0016204"(determination of muscle attachment site)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q9W450|reactome:R-DME-438066|reactome:R-DME-451308|reactome:R-DME-8849932|reactome:R-DME-6794361	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/01/26	2017/06/30	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rogid:Vac41Jh2XszZRaJMe+6fsn0HyKU7227	intact-crc:70DD7B48C2B682D5|rigid:c+1n1Hh7lkNAgsN/r0AmKP9Rpfg	false	sufficient binding region:610-694	sufficient binding region:431-747(IPR001478)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9W450	uniprotkb:Q9VVX3	intact:EBI-149374|uniprotkb:Q9W449|ensemblmetazoa:FBpp0070830	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	psi-mi:q9w450_drome(display_long)|uniprotkb:Grip(gene name)|psi-mi:Grip(display_short)|uniprotkb:Grip-RA(gene name synonym)|uniprotkb:DGrip(gene name synonym)|uniprotkb:Dgrip(gene name synonym)|uniprotkb:Dmel\CG14447(gene name synonym)|uniprotkb:GRIP(gene name synonym)|uniprotkb:dGRIP(gene name synonym)|uniprotkb:dgrip(gene name synonym)|uniprotkb:grip(gene name synonym)|uniprotkb:Dmel_CG14447(orf name)|uniprotkb:CG14447(orf name)|uniprotkb:CG5980(gene name synonym)	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Ataman et al. (2006)	pubmed:16682643|imex:IM-23504	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0465"(DIP)	intact:EBI-2549196|imex:IM-23504-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_572285.2|flybase:FBgn0029830|dip:DIP-21613N|ensemblmetazoa:FBgn0029830(gene)|ensemblmetazoa:FBtr0070865(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005912"(adherens junction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016203"(muscle attachment)|go:"GO:0016204"(determination of muscle attachment site)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q9W450|reactome:R-DME-438066|reactome:R-DME-451308|reactome:R-DME-8849932|reactome:R-DME-6794361	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	-	-	-	figure legend:Fig. 6. C, D, E, C', D' and E'|delivery method:Q9W450 transformation|antibodies:anti-DFz2-N for internalization assay|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2010/01/26	2017/06/30	rogid:Vac41Jh2XszZRaJMe+6fsn0HyKU7227	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	intact-crc:2E30FB368105ABD5|rigid:c+1n1Hh7lkNAgsN/r0AmKP9Rpfg	false	red fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)