#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8ML92 uniprotkb:Q7KNQ9 intact:EBI-2563975|ensemblmetazoa:FBpp0086569 intact:EBI-111569|intact:EBI-2564001|ensemblmetazoa:FBpp0086117|ensemblmetazoa:FBpp0309189 psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name) psi-mi:q7knq9_drome(display_long)|uniprotkb:cnk(gene name)|psi-mi:cnk(display_short)|uniprotkb:CNK(gene name synonym)|uniprotkb:Cnk(gene name synonym)|uniprotkb:Dmel\CG6556(gene name synonym)|uniprotkb:EC2-3(gene name synonym)|uniprotkb:EK2-3(gene name synonym)|uniprotkb:anon-WO0140519.129(gene name synonym)|uniprotkb:anon-WO0257455.27(gene name synonym)|uniprotkb:"l(2)k16314"(gene name synonym)|uniprotkb:sag(gene name synonym)|uniprotkb:CG6556(orf name)|uniprotkb:Dmel_CG6556(orf name) psi-mi:"MI:0663"(confocal microscopy) Roignant et al. (2006) pubmed:16600911|imex:IM-20438 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2564028|imex:IM-20438-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N refseq:NP_725671.1|refseq:NP_001286524.1|dip:DIP-29738N|flybase:FBgn0286070|ensemblmetazoa:FBgn0286070(gene)|ensemblmetazoa:FBtr0086962(transcript)|ensemblmetazoa:FBtr0340214(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-5674135 go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig. 6. A, B and C|delivery method:Q8ML92;Q7KNQ9 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2010/01/28 2014/10/16 rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227 rogid:luUwzC5ziVQ0R3V3gskb0IrPiG47227 intact-crc:F37D489252B91D79|rigid:IvHIlrYkMNBaf9/GhXGQu8kwxQI false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q8ML92 uniprotkb:Q7KNQ9 intact:EBI-2563975|ensemblmetazoa:FBpp0086569 intact:EBI-111569|intact:EBI-2564001|ensemblmetazoa:FBpp0086117|ensemblmetazoa:FBpp0309189 psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name) psi-mi:q7knq9_drome(display_long)|uniprotkb:cnk(gene name)|psi-mi:cnk(display_short)|uniprotkb:CNK(gene name synonym)|uniprotkb:Cnk(gene name synonym)|uniprotkb:Dmel\CG6556(gene name synonym)|uniprotkb:EC2-3(gene name synonym)|uniprotkb:EK2-3(gene name synonym)|uniprotkb:anon-WO0140519.129(gene name synonym)|uniprotkb:anon-WO0257455.27(gene name synonym)|uniprotkb:"l(2)k16314"(gene name synonym)|uniprotkb:sag(gene name synonym)|uniprotkb:CG6556(orf name)|uniprotkb:Dmel_CG6556(orf name) psi-mi:"MI:0018"(two hybrid) Roignant et al. (2006) pubmed:16600911|imex:IM-20438 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2564073|imex:IM-20438-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N refseq:NP_725671.1|refseq:NP_001286524.1|dip:DIP-29738N|flybase:FBgn0286070|ensemblmetazoa:FBgn0286070(gene)|ensemblmetazoa:FBtr0086962(transcript)|ensemblmetazoa:FBtr0340214(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-5674135 - - - figure legend:Fig. 6. D|comment:The interaction seems to be mediated by SAM domain heterodimerization|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/28 2014/10/16 rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227 rogid:luUwzC5ziVQ0R3V3gskb0IrPiG47227 intact-crc:959239B796A2A4C1|rigid:IvHIlrYkMNBaf9/GhXGQu8kwxQI false - necessary binding region:1-85(IPR001660) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24324 uniprotkb:P11346 intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0018"(two hybrid) Roignant et al. (2006) pubmed:16600911|imex:IM-20438 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2564214|imex:IM-20438-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499 refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 - - - figure legend:Fig. 6. D|comment:this interaction is a positive control for yeast two-hybrid assay|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/28 2014/10/16 rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 intact-crc:BB0718BFEE1F7B61|rigid:hhwlNXGA0yislHmqux9SCe1Tyro false - sufficient binding region:376-696 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8ML92 uniprotkb:Q7KNQ9 intact:EBI-2563975|ensemblmetazoa:FBpp0086569 intact:EBI-111569|intact:EBI-2564001|ensemblmetazoa:FBpp0086117|ensemblmetazoa:FBpp0309189 psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name) psi-mi:q7knq9_drome(display_long)|uniprotkb:cnk(gene name)|psi-mi:cnk(display_short)|uniprotkb:CNK(gene name synonym)|uniprotkb:Cnk(gene name synonym)|uniprotkb:Dmel\CG6556(gene name synonym)|uniprotkb:EC2-3(gene name synonym)|uniprotkb:EK2-3(gene name synonym)|uniprotkb:anon-WO0140519.129(gene name synonym)|uniprotkb:anon-WO0257455.27(gene name synonym)|uniprotkb:"l(2)k16314"(gene name synonym)|uniprotkb:sag(gene name synonym)|uniprotkb:CG6556(orf name)|uniprotkb:Dmel_CG6556(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Roignant et al. (2006) pubmed:16600911|imex:IM-20438 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2564242|imex:IM-20438-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N refseq:NP_725671.1|refseq:NP_001286524.1|dip:DIP-29738N|flybase:FBgn0286070|ensemblmetazoa:FBgn0286070(gene)|ensemblmetazoa:FBtr0086962(transcript)|ensemblmetazoa:FBtr0340214(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-5674135 - - - figure legend:Fig. 6. E|delivery method:Q7KNQ9;Q8ML92 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2010/01/28 2014/10/16 rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227 rogid:luUwzC5ziVQ0R3V3gskb0IrPiG47227 intact-crc:65ACE27A4138B257|rigid:IvHIlrYkMNBaf9/GhXGQu8kwxQI false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)