#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02462	uniprotkb:P02462	intact:EBI-2432478|uniprotkb:B1AM70|uniprotkb:A7E2W4|uniprotkb:Q1P9S9|uniprotkb:Q5VWF6|uniprotkb:Q86X41|uniprotkb:Q8NF88|uniprotkb:Q9NYC5|uniprotkb:F5H5K0|ensembl:ENSP00000364979	intact:EBI-2432478|uniprotkb:B1AM70|uniprotkb:A7E2W4|uniprotkb:Q1P9S9|uniprotkb:Q5VWF6|uniprotkb:Q86X41|uniprotkb:Q8NF88|uniprotkb:Q9NYC5|uniprotkb:F5H5K0|ensembl:ENSP00000364979	psi-mi:co4a1_human(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:co4a1_human(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Than et al. (2002)	pubmed:12011424|imex:IM-19466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535681|wwpdb:1li1|imex:IM-19466-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290039.1|refseq:NP_001836.3|ensembl:ENSG00000187498(gene)|ensembl:ENST00000375820(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P02462|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NAY|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	refseq:NP_001290039.1|refseq:NP_001836.3|ensembl:ENSG00000187498(gene)|ensembl:ENST00000375820(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P02462|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NAY|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	figure legend:Fig 4.|3d-structure:"The asymmetric unit contains 1,359 aa in four alpha 1(IV) and two alpha 2(IV) NC1 chains, which are tightly packed into a distinct hexameric particle. Two caps, made up of the trimeric NC1 ends of two opposing collagen IV protomers  juxtapose each other via a central planar interface. In each (of the two) NC1 caps, two alpha 1 chains and one alpha 2 chain are segmentally arranged, displaced by 120 degrees around a central tunnel of varying width."|3d-r-factors:"Working R factor of 18.2%, Free R-factor: 20.2%."|3d-resolution:1.9A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/19	2018/06/01	rogid:/U3Xsl1lPZnPBfd1cRVDqtuvVb49606	rogid:/U3Xsl1lPZnPBfd1cRVDqtuvVb49606	intact-crc:3B1259710323B8FB|rigid:yO1sW+GCmKKtT+xBxMnscYP3u/E	false	sufficient binding region:?-?(IPR001442)|binding-associated region:1533-1533|binding-associated region:1651-1651	sufficient binding region:?-?(IPR001442)|binding-associated region:1533-1533|binding-associated region:1651-1651	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02462	uniprotkb:P08572	intact:EBI-2432478|uniprotkb:B1AM70|uniprotkb:A7E2W4|uniprotkb:Q1P9S9|uniprotkb:Q5VWF6|uniprotkb:Q86X41|uniprotkb:Q8NF88|uniprotkb:Q9NYC5|uniprotkb:F5H5K0|ensembl:ENSP00000364979	intact:EBI-2432506|uniprotkb:Q14052|uniprotkb:Q548C3|uniprotkb:Q5VZA9|uniprotkb:Q66K23|ensembl:ENSP00000353654	psi-mi:co4a1_human(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:co4a2_human(display_long)|uniprotkb:COL4A2(gene name)|psi-mi:COL4A2(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Than et al. (2002)	pubmed:12011424|imex:IM-19466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535681|wwpdb:1li1|imex:IM-19466-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290039.1|refseq:NP_001836.3|ensembl:ENSG00000187498(gene)|ensembl:ENST00000375820(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P02462|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NAY|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	refseq:NP_001837.2|ensembl:ENSG00000134871(gene)|ensembl:ENST00000360467(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NB2|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	figure legend:Fig 4.|3d-structure:"The asymmetric unit contains 1,359 aa in four alpha 1(IV) and two alpha 2(IV) NC1 chains, which are tightly packed into a distinct hexameric particle. Two caps, made up of the trimeric NC1 ends of two opposing collagen IV protomers  juxtapose each other via a central planar interface. In each (of the two) NC1 caps, two alpha 1 chains and one alpha 2 chain are segmentally arranged, displaced by 120 degrees around a central tunnel of varying width."|3d-r-factors:"Working R factor of 18.2%, Free R-factor: 20.2%."|3d-resolution:1.9A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/19	2018/06/01	rogid:/U3Xsl1lPZnPBfd1cRVDqtuvVb49606	rogid:2jSdn1hb9JtAPdSLo82KAbqdzr09606	intact-crc:3B1259710323B8FB|rigid:yO1sW+GCmKKtT+xBxMnscYP3u/E	false	sufficient binding region:?-?(IPR001442)|binding-associated region:1533-1533|binding-associated region:1651-1651	sufficient binding region:1485-1712(IPR001442)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08572	uniprotkb:P02462	intact:EBI-2432506|uniprotkb:Q14052|uniprotkb:Q548C3|uniprotkb:Q5VZA9|uniprotkb:Q66K23|ensembl:ENSP00000353654	intact:EBI-2432478|uniprotkb:B1AM70|uniprotkb:A7E2W4|uniprotkb:Q1P9S9|uniprotkb:Q5VWF6|uniprotkb:Q86X41|uniprotkb:Q8NF88|uniprotkb:Q9NYC5|uniprotkb:F5H5K0|ensembl:ENSP00000364979	psi-mi:co4a2_human(display_long)|uniprotkb:COL4A2(gene name)|psi-mi:COL4A2(display_short)	psi-mi:co4a1_human(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Than et al. (2002)	pubmed:12011424|imex:IM-19466	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536092|imex:IM-19466-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001837.2|ensembl:ENSG00000134871(gene)|ensembl:ENST00000360467(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NB2|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	refseq:NP_001290039.1|refseq:NP_001836.3|ensembl:ENSG00000187498(gene)|ensembl:ENST00000375820(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P02462|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NAY|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	caution:"The expected cross-linked peptides are stated as  (alpha 1: Asn-77�Arg-102/Lys�204�Arg-216; alpha 2: Ser-78�Arg-107/Tyr-189�Arg-216. However there is no Serine at position 78 in COL4A2 NC1 as shown on Fig 3; a Lysine assumed to be present instead, as given on Fig 3."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/19	2018/06/01	rogid:2jSdn1hb9JtAPdSLo82KAbqdzr09606	rogid:/U3Xsl1lPZnPBfd1cRVDqtuvVb49606	intact-crc:4B4B4ADB275BA881|rigid:yO1sW+GCmKKtT+xBxMnscYP3u/E	false	necessary binding region:1485-1712(IPR001442)|identified peptide:1672-1699|identified peptide:1564-1589	sufficient binding region:1441-1669(IPR001442)|identified peptide:1517-1542|identified peptide:1644-1656	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)