#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9URY2 uniprotkb:O94534 intact:EBI-1556697|uniprotkb:Q9UU56|ensemblfungi:"SPAC890.02c.1:pep" intact:EBI-1556727|ensemblfungi:"SPCC895.07.1:pep" psi-mi:alp7_schpo(display_long)|uniprotkb:Altered polarity protein 7(gene name synonym)|uniprotkb:Transforming acidic coiled-coil protein mia1(gene name synonym)|uniprotkb:alp7(gene name)|psi-mi:alp7(display_short)|uniprotkb:mia1(gene name synonym)|uniprotkb:SPAC890.02c(orf name) psi-mi:alp14_schpo(display_long)|uniprotkb:Altered polarity protein 14(gene name synonym)|uniprotkb:alp14(gene name)|psi-mi:alp14(display_short)|uniprotkb:mtc1(gene name synonym)|uniprotkb:SPCC895.07(orf name) psi-mi:"MI:0018"(two hybrid) Sato et al. (2009) pubmed:19696784|imex:IM-13941|mint:MINT-7294947|doi:10.1038/embor.2009.158 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7183772|mint:MINT-7294966|imex:IM-13941-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594820.1|dip:DIP-39987N|mint:Q9URY2|ensemblfungi:SPAC890.02c(gene)|ensemblfungi:SPAC890.02c.1(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0061804"("mitotic spindle formation (spindle phase one)")|go:"GO:0061805"("mitotic spindle elongation (spindle phase three)")|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR024312|mint:MINT-7294969(identity) refseq:NP_588048.1|dip:DIP-39988N|mint:O94534|ensemblfungi:SPCC895.07(gene)|ensemblfungi:SPCC895.07.1(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005816"(spindle pole body)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051417"(microtubule nucleation by spindle pole body)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1904511"(cytoplasmic microtubule plus-end)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|mint:MINT-7294968(identity) - crc64:22B4216C196E310C crc64:78B2027F0EC9A939 comment:mint|figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/10/22 2014/10/16 rogid:XmrN90PFU3YvbJEmhfBcRWl/Wno284812 rogid:YyWKjCRckFGHm3Yb5EibQY7ByPw284812 intact-crc:A3D1C6732968428A|rigid:IXc5s3OFC3Fx5SQ3W4UuPoC90HE false tag:?-?(MINT-7295060)|mutation disrupting interaction:461-461(MINT-7295063) binding-associated region:696-809(MINT-7295074)|tag:?-?(MINT-7295071) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01112 uniprotkb:P04049 intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Sato et al. (2009) pubmed:19696784|imex:IM-13941|mint:MINT-7294947|doi:10.1038/embor.2009.158 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7183816|mint:MINT-7295101|imex:IM-13941-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N|mint:MINT-7295103(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|mint:MINT-7295104(identity) - - - comment:homomint|comment:mint|figure legend:f2d f2e|comment:Ras and Raf taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/10/22 2014/10/16 rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:EBDBA98ED4E3CF07|rigid:CIpfJdMn9YlSuwL3iJyHtsp5lK8 false tag:?-?(MINT-7295110) tag:?-?(MINT-7295106) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94534 uniprotkb:Q9URY2 intact:EBI-1556727|ensemblfungi:"SPCC895.07.1:pep" intact:EBI-1556697|uniprotkb:Q9UU56|ensemblfungi:"SPAC890.02c.1:pep" psi-mi:alp14_schpo(display_long)|uniprotkb:Altered polarity protein 14(gene name synonym)|uniprotkb:alp14(gene name)|psi-mi:alp14(display_short)|uniprotkb:mtc1(gene name synonym)|uniprotkb:SPCC895.07(orf name) psi-mi:alp7_schpo(display_long)|uniprotkb:Altered polarity protein 7(gene name synonym)|uniprotkb:Transforming acidic coiled-coil protein mia1(gene name synonym)|uniprotkb:alp7(gene name)|psi-mi:alp7(display_short)|uniprotkb:mia1(gene name synonym)|uniprotkb:SPAC890.02c(orf name) psi-mi:"MI:0018"(two hybrid) Sato et al. (2009) pubmed:19696784|imex:IM-13941|mint:MINT-7294947|doi:10.1038/embor.2009.158 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7183796|mint:MINT-7295077|imex:IM-13941-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_588048.1|dip:DIP-39988N|mint:O94534|ensemblfungi:SPCC895.07(gene)|ensemblfungi:SPCC895.07.1(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005816"(spindle pole body)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051417"(microtubule nucleation by spindle pole body)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1904511"(cytoplasmic microtubule plus-end)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|mint:MINT-7295085(identity) refseq:NP_594820.1|dip:DIP-39987N|mint:Q9URY2|ensemblfungi:SPAC890.02c(gene)|ensemblfungi:SPAC890.02c.1(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0061804"("mitotic spindle formation (spindle phase one)")|go:"GO:0061805"("mitotic spindle elongation (spindle phase three)")|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR024312|mint:MINT-7295079(identity) - crc64:78B2027F0EC9A939 crc64:22B4216C196E310C figure legend:f2e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/10/22 2014/10/16 rogid:YyWKjCRckFGHm3Yb5EibQY7ByPw284812 rogid:XmrN90PFU3YvbJEmhfBcRWl/Wno284812 intact-crc:0CCC0B81B1CC2458|rigid:IXc5s3OFC3Fx5SQ3W4UuPoC90HE false tag:?-?(MINT-7295088) tag:?-?(MINT-7295082)|binding-associated region:45-474(MINT-7295094) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9URY2 uniprotkb:O94534 intact:EBI-1556697|uniprotkb:Q9UU56|ensemblfungi:"SPAC890.02c.1:pep" intact:EBI-1556727|ensemblfungi:"SPCC895.07.1:pep" psi-mi:alp7_schpo(display_long)|uniprotkb:Altered polarity protein 7(gene name synonym)|uniprotkb:Transforming acidic coiled-coil protein mia1(gene name synonym)|uniprotkb:alp7(gene name)|psi-mi:alp7(display_short)|uniprotkb:mia1(gene name synonym)|uniprotkb:SPAC890.02c(orf name) psi-mi:alp14_schpo(display_long)|uniprotkb:Altered polarity protein 14(gene name synonym)|uniprotkb:alp14(gene name)|psi-mi:alp14(display_short)|uniprotkb:mtc1(gene name synonym)|uniprotkb:SPCC895.07(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Sato et al. (2009) pubmed:19696784|imex:IM-13941|mint:MINT-7294947|doi:10.1038/embor.2009.158 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7183845|mint:MINT-7295138|imex:IM-13941-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_594820.1|dip:DIP-39987N|mint:Q9URY2|ensemblfungi:SPAC890.02c(gene)|ensemblfungi:SPAC890.02c.1(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051415"(microtubule nucleation by interphase microtubule organizing center)|go:"GO:0061804"("mitotic spindle formation (spindle phase one)")|go:"GO:0061805"("mitotic spindle elongation (spindle phase three)")|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR024312|mint:MINT-7295144(identity) refseq:NP_588048.1|dip:DIP-39988N|mint:O94534|ensemblfungi:SPCC895.07(gene)|ensemblfungi:SPCC895.07.1(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005816"(spindle pole body)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051417"(microtubule nucleation by spindle pole body)|go:"GO:0061863"(microtubule plus end polymerase)|go:"GO:0070850"(TACC/TOG complex)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0099070"(static microtubule bundle)|go:"GO:0140210"(protein transport along microtubule to kinetochore)|go:"GO:1904511"(cytoplasmic microtubule plus-end)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990571"(meiotic centromere clustering)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|mint:MINT-7295140(identity) go:"GO:0015630"(microtubule cytoskeleton) crc64:22B4216C196E310C crc64:78B2027F0EC9A939 comment:mint|figure legend:f1c f3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") - 2009/10/22 2014/10/16 rogid:XmrN90PFU3YvbJEmhfBcRWl/Wno284812 rogid:YyWKjCRckFGHm3Yb5EibQY7ByPw284812 intact-crc:EA993517E4D51473|rigid:IXc5s3OFC3Fx5SQ3W4UuPoC90HE false green fluorescent protein tag:?-?(MINT-7295147) red fluorescent protein tag:?-?(MINT-7295141) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)