#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29460	uniprotkb:Q9NPF7	intact:EBI-1029614|ensembl:ENSP00000231228	intact:EBI-2481154|ensembl:ENSP00000228534|uniprotkb:Q6NZ80|uniprotkb:Q6NZ82|uniprotkb:Q9H2A5	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:il23a_human(display_long)|uniprotkb:IL23A(gene name)|psi-mi:IL23A(display_short)|uniprotkb:SGRF(gene name synonym)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)|uniprotkb:UNQ2498/PRO5798(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481178|imex:IM-20397-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	ensembl:ENSG00000110944(gene)|ensembl:ENST00000228534(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|rcsb pdb:3D85|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0006954"(inflammatory response)|rcsb pdb:3DUH|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933|rcsb pdb:3D87|refseq:XP_011536779.1|refseq:NP_057668.1	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/24	2014/10/16	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	rogid:cGuBTF6IoaUFDF7jhyLoNrfYvXg9606	intact-crc:4B8AF7EB8EC859B0|rigid:jt3A9ryy2oV8Hf0aYUXzXEFqztU	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9EQ14	uniprotkb:P29460	intact:EBI-2481329|ensembl:ENSMUSP00000026449	intact:EBI-1029614|ensembl:ENSP00000231228	psi-mi:il23a_mouse(display_long)|uniprotkb:Il23a(gene name)|psi-mi:Il23a(display_short)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481346|imex:IM-20397-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025383(gene)|ensembl:ENSMUST00000026449(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|reactome:R-MMU-9020933|refseq:NP_112542.1	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/24	2014/10/16	rogid:ypYoRZOdiyHfQ5FHmqnYldYc/6Q10090	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	intact-crc:3CBD7A5A72F19AE9|rigid:sArQHeMF+cc8CjRKi0ERzy3yIEA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NPF7	uniprotkb:P29460	intact:EBI-2481154|ensembl:ENSP00000228534|uniprotkb:Q6NZ80|uniprotkb:Q6NZ82|uniprotkb:Q9H2A5	intact:EBI-1029614|ensembl:ENSP00000231228	psi-mi:il23a_human(display_long)|uniprotkb:IL23A(gene name)|psi-mi:IL23A(display_short)|uniprotkb:SGRF(gene name synonym)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)|uniprotkb:UNQ2498/PRO5798(orf name)	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481320|imex:IM-20397-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110944(gene)|ensembl:ENST00000228534(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|rcsb pdb:3D85|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0006954"(inflammatory response)|rcsb pdb:3DUH|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933|rcsb pdb:3D87|refseq:XP_011536779.1|refseq:NP_057668.1	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/24	2014/10/16	rogid:cGuBTF6IoaUFDF7jhyLoNrfYvXg9606	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	intact-crc:2BFE8DAFE7276D37|rigid:jt3A9ryy2oV8Hf0aYUXzXEFqztU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29460	uniprotkb:Q9EQ14	intact:EBI-1029614|ensembl:ENSP00000231228	intact:EBI-2481329|ensembl:ENSMUSP00000026449	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:il23a_mouse(display_long)|uniprotkb:Il23a(gene name)|psi-mi:Il23a(display_short)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481382|imex:IM-20397-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	ensembl:ENSMUSG00000025383(gene)|ensembl:ENSMUST00000026449(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|reactome:R-MMU-9020933|refseq:NP_112542.1	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/24	2014/10/16	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	rogid:ypYoRZOdiyHfQ5FHmqnYldYc/6Q10090	intact-crc:FB82CC4B9A663856|rigid:sArQHeMF+cc8CjRKi0ERzy3yIEA	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P43432	uniprotkb:Q9EQ14	intact:EBI-2481353|ensembl:ENSMUSP00000099860|ensembl:ENSMUSP00000125867|uniprotkb:Q9QUM1	intact:EBI-2481329|ensembl:ENSMUSP00000026449	psi-mi:il12b_mouse(display_long)|uniprotkb:Il12b(gene name)|psi-mi:Il12b(display_short)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)	psi-mi:il23a_mouse(display_long)|uniprotkb:Il23a(gene name)|psi-mi:Il23a(display_short)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481396|imex:IM-20397-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019955"(cytokine binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031904"(endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0007166"(cell surface receptor signaling pathway)|ensembl:ENSMUSG00000004296(gene)|ensembl:ENSMUST00000102796(transcript)|ensembl:ENSMUST00000170513(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|rcsb pdb:6SMC|interpro:IPR003961(Fibronectin, type III)|rcsb pdb:6SP3|reactome:R-MMU-9020591|reactome:R-MMU-9020933|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:6SFF|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045519"(interleukin-23 receptor binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0032733"(positive regulation of interleukin-10 production)|refseq:NP_001290173.1|dip:DIP-6013N	ensembl:ENSMUSG00000025383(gene)|ensembl:ENSMUST00000026449(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|reactome:R-MMU-9020933|refseq:NP_112542.1	-	-	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/11/24	2014/10/16	rogid:CZ4ont8JewIa3eNu9IaR358GS9Q10090	rogid:ypYoRZOdiyHfQ5FHmqnYldYc/6Q10090	intact-crc:9206530229DAD45D|rigid:2QAsXUOB85kHFaE2yG5lqgrGOmw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EQ14	uniprotkb:P43432	intact:EBI-2481329|ensembl:ENSMUSP00000026449	intact:EBI-2481353|ensembl:ENSMUSP00000099860|ensembl:ENSMUSP00000125867|uniprotkb:Q9QUM1	psi-mi:il23a_mouse(display_long)|uniprotkb:Il23a(gene name)|psi-mi:Il23a(display_short)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)	psi-mi:il12b_mouse(display_long)|uniprotkb:Il12b(gene name)|psi-mi:Il12b(display_short)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481408|imex:IM-20397-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025383(gene)|ensembl:ENSMUST00000026449(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|reactome:R-MMU-9020933|refseq:NP_112542.1	go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019955"(cytokine binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031904"(endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0007166"(cell surface receptor signaling pathway)|ensembl:ENSMUSG00000004296(gene)|ensembl:ENSMUST00000102796(transcript)|ensembl:ENSMUST00000170513(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|rcsb pdb:6SMC|interpro:IPR003961(Fibronectin, type III)|rcsb pdb:6SP3|reactome:R-MMU-9020591|reactome:R-MMU-9020933|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:6SFF|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045519"(interleukin-23 receptor binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0032733"(positive regulation of interleukin-10 production)|refseq:NP_001290173.1|dip:DIP-6013N	-	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/24	2014/10/16	rogid:ypYoRZOdiyHfQ5FHmqnYldYc/6Q10090	rogid:CZ4ont8JewIa3eNu9IaR358GS9Q10090	intact-crc:2089EC1B66F03B86|rigid:2QAsXUOB85kHFaE2yG5lqgrGOmw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P43432	uniprotkb:Q9EQ14	intact:EBI-2481353|ensembl:ENSMUSP00000099860|ensembl:ENSMUSP00000125867|uniprotkb:Q9QUM1	intact:EBI-2481329|ensembl:ENSMUSP00000026449	psi-mi:il12b_mouse(display_long)|uniprotkb:Il12b(gene name)|psi-mi:Il12b(display_short)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)	psi-mi:il23a_mouse(display_long)|uniprotkb:Il23a(gene name)|psi-mi:Il23a(display_short)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481419|imex:IM-20397-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019955"(cytokine binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031904"(endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0007166"(cell surface receptor signaling pathway)|ensembl:ENSMUSG00000004296(gene)|ensembl:ENSMUST00000102796(transcript)|ensembl:ENSMUST00000170513(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|rcsb pdb:6SMC|interpro:IPR003961(Fibronectin, type III)|rcsb pdb:6SP3|reactome:R-MMU-9020591|reactome:R-MMU-9020933|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:6SFF|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045519"(interleukin-23 receptor binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0032733"(positive regulation of interleukin-10 production)|refseq:NP_001290173.1|dip:DIP-6013N	ensembl:ENSMUSG00000025383(gene)|ensembl:ENSMUST00000026449(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|reactome:R-MMU-9020933|refseq:NP_112542.1	-	-	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2009/11/24	2014/10/16	rogid:CZ4ont8JewIa3eNu9IaR358GS9Q10090	rogid:ypYoRZOdiyHfQ5FHmqnYldYc/6Q10090	intact-crc:AC657F79CEC7AE75|rigid:2QAsXUOB85kHFaE2yG5lqgrGOmw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42701	intact:EBI-2481430	intact:EBI-2481251|ensembl:ENSP00000470788|ensembl:ENSP00000472165|uniprotkb:A8K308|uniprotkb:B2RPF1|uniprotkb:B7ZKK3|uniprotkb:Q8N6Q7	-	psi-mi:i12r1_human(display_long)|uniprotkb:IL12RB1(gene name)|psi-mi:IL12RB1(display_short)|uniprotkb:IL12R(gene name synonym)|uniprotkb:IL12RB(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:il23a_il-12b_human(display_short)|psi-mi:EBI-2481430(display_long)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481434|imex:IM-20397-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000096996(gene)|ensembl:ENST00000593993(transcript)|ensembl:ENST00000600835(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:6WDP|rcsb pdb:6WDQ|reactome:R-HSA-9020591|reactome:R-HSA-9020933|go:"GO:0072536"(interleukin-23 receptor complex)|refseq:NP_005526.1|refseq:NP_714912.1|refseq:NP_001276952.1|dip:DIP-3773N	uniprotkb:Q9NPF7(multiple parent)|uniprotkb:P29460(multiple parent)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/24	2014/10/16	rogid:i+z7ptusYAIgGyvLrRce6Dmp5q89606	-	intact-crc:A3829B88B77FB0C2	false	-	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P42701	uniprotkb:P29459	intact:EBI-2481251|ensembl:ENSP00000470788|ensembl:ENSP00000472165|uniprotkb:A8K308|uniprotkb:B2RPF1|uniprotkb:B7ZKK3|uniprotkb:Q8N6Q7	intact:EBI-1029636|uniprotkb:Q96QZ1|ensembl:ENSP00000303231	psi-mi:i12r1_human(display_long)|uniprotkb:IL12RB1(gene name)|psi-mi:IL12RB1(display_short)|uniprotkb:IL12R(gene name synonym)|uniprotkb:IL12RB(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:il12a_human(display_long)|uniprotkb:IL12A(gene name)|psi-mi:IL12A(display_short)|uniprotkb:NKSF1(gene name synonym)|uniprotkb:IL-12 subunit p35(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 35 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481444|imex:IM-20397-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000096996(gene)|ensembl:ENST00000593993(transcript)|ensembl:ENST00000600835(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:6WDP|rcsb pdb:6WDQ|reactome:R-HSA-9020591|reactome:R-HSA-9020933|go:"GO:0072536"(interleukin-23 receptor complex)|refseq:NP_005526.1|refseq:NP_714912.1|refseq:NP_001276952.1|dip:DIP-3773N	refseq:NP_000873.2|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042163"(interleukin-12 beta subunit binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0045513"(interleukin-27 binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|ensembl:ENSG00000168811(gene)|ensembl:ENST00000305579(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010224"(response to UV-B)|go:"GO:0016477"(cell migration)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR004281(Interleukin-12 alpha subunit)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1F45|rcsb pdb:3HMX|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8984722|reactome:R-HSA-9020591|go:"GO:0050830"(defense response to Gram-positive bacterium)|dip:DIP-3772N	-	-	-	figure legend:Fig. 7A|caution:No detail given of production/purchase of IL-12.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/24	2014/10/16	rogid:i+z7ptusYAIgGyvLrRce6Dmp5q89606	rogid:NGpK6IuMMGg9v1dFJB4m29s02Ng9606	intact-crc:19BA4AEFF27AC755|rigid:hq/JBZYwqWTDWjRbSFBXrkylXoI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P42701	uniprotkb:P29460	intact:EBI-2481251|ensembl:ENSP00000470788|ensembl:ENSP00000472165|uniprotkb:A8K308|uniprotkb:B2RPF1|uniprotkb:B7ZKK3|uniprotkb:Q8N6Q7	intact:EBI-1029614|ensembl:ENSP00000231228	psi-mi:i12r1_human(display_long)|uniprotkb:IL12RB1(gene name)|psi-mi:IL12RB1(display_short)|uniprotkb:IL12R(gene name synonym)|uniprotkb:IL12RB(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481444|imex:IM-20397-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000096996(gene)|ensembl:ENST00000593993(transcript)|ensembl:ENST00000600835(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:6WDP|rcsb pdb:6WDQ|reactome:R-HSA-9020591|reactome:R-HSA-9020933|go:"GO:0072536"(interleukin-23 receptor complex)|refseq:NP_005526.1|refseq:NP_714912.1|refseq:NP_001276952.1|dip:DIP-3773N	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	-	-	-	figure legend:Fig. 7A|caution:No detail given of production/purchase of IL-12.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/24	2014/10/16	rogid:i+z7ptusYAIgGyvLrRce6Dmp5q89606	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	intact-crc:19BA4AEFF27AC755|rigid:hq/JBZYwqWTDWjRbSFBXrkylXoI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-2481451	uniprotkb:Q60837	-	intact:EBI-2481455|uniprotkb:Q3UV59|ensembl:ENSMUSP00000000808	psi-mi:il23a-il12b_mouse(display_short)|psi-mi:EBI-2481451(display_long)	psi-mi:i12r1_mouse(display_long)|uniprotkb:Il12rb1(gene name)|psi-mi:Il12rb1(display_short)|uniprotkb:Il12rb(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Oppmann et al. (2000)	pubmed:11114383|imex:IM-20397	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2481470|imex:IM-20397-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q9EQ14(multiple parent)|uniprotkb:P43432(multiple parent)	ensembl:ENSMUSG00000000791(gene)|ensembl:ENSMUST00000000808(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072536"(interleukin-23 receptor complex)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|reactome:R-MMU-9020591|reactome:R-MMU-9020933|refseq:NP_032379.2	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/24	2014/10/16	-	rogid:9Cc5us066C300BwWqKD3d6oi9cI10090	intact-crc:CB856CE325EA5085	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)