#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53350	uniprotkb:Q9NR09	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765195|imex:IM-11898-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	go:"GO:0005819"(spindle)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/04/14	2014/10/16	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:732294A292C798CA|rigid:SdjIM//mslKvMXG6e3B9iq1jUVg	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9NR09	uniprotkb:Q02241	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-306852|uniprotkb:Q8WVP0|ensembl:ENSP00000260363|ensembl:ENSP00000497065|intact:EBI-2558308|uniprotkb:B4E1K0	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:kif23_human(display_long)|uniprotkb:KIF23(gene name)|psi-mi:KIF23(display_short)|uniprotkb:KNSL5(gene name synonym)|uniprotkb:MKLP1(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 1(gene name synonym)|uniprotkb:Kinesin-like protein 5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765988|imex:IM-11898-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_004847.2|refseq:NP_612565.1|ensembl:ENSG00000137807(gene)|ensembl:ENST00000260363(transcript)|ensembl:ENST00000647715(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000281"(mitotic cytokinesis)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR038105|mint:Q02241|rcsb pdb:3VHX|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|interpro:IPR032384|reactome:R-HSA-983189|ensembl:ENSP00000260363|ensembl:ENST00000352331|ensembl:ENSP00000304978|ensembl:ENSP00000497065|dip:DIP-40359N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1|figure legend:Supp. Fig. 6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:akVjKfOv4g4nEsGN8E3lQ2vCseQ9606	intact-crc:B183FA34CBCD7534|rigid:sxQ1od7wp4Syi9uJu4g3TOhZj8A	false	green fluorescent protein tag:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96GD4	uniprotkb:Q9NR09	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765202|imex:IM-11898-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	go:"GO:0051233"(spindle midzone)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/04/14	2014/10/16	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:C5DBCB356266BB30|rigid:p08sxGfNCZGSRKQNkgRsVGqG8Jc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P61028	uniprotkb:Q9NR09	intact:EBI-911674|ensembl:ENSMUSP00000041857|uniprotkb:Q3U1Z3	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:rab8b_mouse(display_long)|uniprotkb:Rab8b(gene name)|psi-mi:Rab8b(display_short)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765223|imex:IM-11898-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775589.1|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150115"(cell-substrate junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|ensembl:ENSMUSG00000036943(gene)|ensembl:ENSMUST00000041139(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016604"(nuclear body)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	go:"GO:0005768"(endosome)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/04/14	2014/10/16	rogid:bRfYongYDkw/3XyTJ8jMVUZ001E10090	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:6ED35FC797F396BF|rigid:qOy5LbWoAL0vmaBwsBbdjK4nOAw	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q13439	uniprotkb:Q9NR09	intact:EBI-1037845|uniprotkb:Q13270|uniprotkb:Q13654|uniprotkb:Q14436|uniprotkb:F8W8Q7|uniprotkb:Q59EW8|ensembl:ENSP00000354486	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:goga4_human(display_long)|uniprotkb:GOLGA4(gene name)|psi-mi:GOLGA4(display_short)|uniprotkb:Trans-Golgi p230(gene name synonym)|uniprotkb:256 kDa golgin(gene name synonym)|uniprotkb:Golgin-245(gene name synonym)|uniprotkb:Protein 72.1(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765274|imex:IM-11898-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166184.1|refseq:NP_002069.2|ensembl:ENSG00000144674(gene)|ensembl:ENST00000361924(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000237(GRIP)|rcsb pdb:1R4A|rcsb pdb:1UPT|reactome:R-HSA-6811440|reactome:R-HSA-9673768	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	go:"GO:0030496"(midbody)|go:"GO:0005802"(trans-Golgi network)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Fig. 1D, Supp 2B|comment:Interactions between BIRC6 and gamma and alpha tubulins were also observed but the antibodies used could not differentiate between multiple gene products.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/04/14	2014/10/16	rogid:iRvTCfQleDllP1zq0dlAVyX58JU9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:B0F1A377EFE6700F|rigid:4qTwXaTRgo5geXgtlaVSvVaXSSo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q96A65	uniprotkb:Q9NR09	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765634|imex:IM-11898-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	go:"GO:0005634"(nucleus)	-	-	author-identifiers:Q9NR09 BRUCE; Q96A65 SEC8|figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2008/04/14	2014/10/16	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:66E7B38030F03D4E|rigid:QDUcoddOL1H9bV15Pxjp/uQHdDE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O88738	uniprotkb:P53350	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765334|imex:IM-11898-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; Q02750 MEK1|figure legend:Supp. Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	intact-crc:1177C644B93A5C8A|rigid:uzRBsihUyiDfugQHtBHm9mZA5NU	false	sufficient binding region:29-676|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88738	uniprotkb:Q02750	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765334|imex:IM-11898-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; Q02750 MEK1|figure legend:Supp. Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:1177C644B93A5C8A|rigid:uzRBsihUyiDfugQHtBHm9mZA5NU	false	sufficient binding region:29-676|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88738	uniprotkb:P06493	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765369|imex:IM-11898-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; P06493 CDK1|figure legend:Supp. Fig. 3C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:3ACAD2CAAB59899C|rigid:vz4dOQtQ/tHyIZPFH9GnfewyoBw	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15392	uniprotkb:O88738	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765452|imex:IM-11898-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; O15392 SURVIVIN|figure legend:Supp. Fig. 3I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	intact-crc:617B8F1B1B3F870E|rigid:6BviI6CBbLZF4KVab2w5LBSh44I	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88738	uniprotkb:O60645	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	intact:EBI-1052278|uniprotkb:Q8TEN6|uniprotkb:Q8WUW0|uniprotkb:Q96DI4|uniprotkb:Q6P2E8|ensembl:ENSP00000323377|ensembl:ENSP00000425587|intact:EBI-11944037	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:exoc3_human(display_long)|uniprotkb:Exocyst complex component Sec6(gene name synonym)|uniprotkb:EXOC3(gene name)|psi-mi:EXOC3(display_short)|uniprotkb:SEC6(gene name synonym)|uniprotkb:SEC6L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765706|imex:IM-11898-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	refseq:XP_016864492.1|refseq:XP_016864493.1|ensembl:ENSG00000180104(gene)|ensembl:ENST00000315013(transcript)|ensembl:ENST00000512944(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000149"(SNARE binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051601"(exocyst localization)|interpro:IPR010326(Exocyst complex component Sec6)|interpro:IPR042532|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0030426"(growth cone)|refseq:NP_009208.2	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; Q96A65 SEC8; O60645 SEC6|figure legend:Fig. 2C|comment:RAB8 and RAB11 were also identified in this coimmunoprecipitate but the antibodies used were not specific for a single gene product.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2019/04/15	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	rogid:7nhIGGYkkrej3iW0UKDqP5BwUz09606	intact-crc:ECA90B035071C5EB|rigid:YycbaqG9ouHF+vkj0IJACse4GY0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88738	uniprotkb:Q96A65	intact:EBI-912068|uniprotkb:E9PYU6|uniprotkb:Q69ZM5|uniprotkb:Q8BNX0|uniprotkb:Q8BR72|uniprotkb:Q8BRV7|uniprotkb:Q8C737|ensembl:ENSMUSP00000138333	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	psi-mi:birc6_mouse(display_long)|uniprotkb:Birc6(gene name)|psi-mi:Birc6(display_short)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:Kiaa1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765706|imex:IM-11898-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031592.3|ensembl:ENSMUSG00000024073(gene)|ensembl:ENSMUST00000182597(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001890"(placenta development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|interpro:IPR036322|mint:O88738	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:O88738 Bruce; Q96A65 SEC8; O60645 SEC6|figure legend:Fig. 2C|comment:RAB8 and RAB11 were also identified in this coimmunoprecipitate but the antibodies used were not specific for a single gene product.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2019/04/15	rogid:Pa62v6xd4WQNOHRL5c+Wo8gf5wo10090	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	intact-crc:ECA90B035071C5EB|rigid:YycbaqG9ouHF+vkj0IJACse4GY0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96A65	uniprotkb:Q9NR09	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765751|imex:IM-11898-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q96A65 SEC8|figure legend:Fig. Supp 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:3937BB2674F6A38C|rigid:QDUcoddOL1H9bV15Pxjp/uQHdDE	false	-	sufficient binding region:29-550|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:P61028	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-911674|ensembl:ENSMUSP00000041857|uniprotkb:Q3U1Z3	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:rab8b_mouse(display_long)|uniprotkb:Rab8b(gene name)|psi-mi:Rab8b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765759|imex:IM-11898-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_775589.1|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150115"(cell-substrate junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|ensembl:ENSMUSG00000036943(gene)|ensembl:ENSMUST00000041139(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016604"(nuclear body)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Supp. Fig. 4C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:bRfYongYDkw/3XyTJ8jMVUZ001E10090	intact-crc:E94EFABC02F34C29|rigid:qOy5LbWoAL0vmaBwsBbdjK4nOAw	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:Q02241	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-306852|uniprotkb:Q8WVP0|ensembl:ENSP00000260363|ensembl:ENSP00000497065|intact:EBI-2558308|uniprotkb:B4E1K0	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:kif23_human(display_long)|uniprotkb:KIF23(gene name)|psi-mi:KIF23(display_short)|uniprotkb:KNSL5(gene name synonym)|uniprotkb:MKLP1(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 1(gene name synonym)|uniprotkb:Kinesin-like protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765803|imex:IM-11898-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_004847.2|refseq:NP_612565.1|ensembl:ENSG00000137807(gene)|ensembl:ENST00000260363(transcript)|ensembl:ENST00000647715(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000281"(mitotic cytokinesis)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR038105|mint:Q02241|rcsb pdb:3VHX|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|interpro:IPR032384|reactome:R-HSA-983189|ensembl:ENSP00000260363|ensembl:ENST00000352331|ensembl:ENSP00000304978|ensembl:ENSP00000497065|dip:DIP-40359N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1|figure legend:Fig. 2J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:akVjKfOv4g4nEsGN8E3lQ2vCseQ9606	intact-crc:55B0CDB6187449E4|rigid:sxQ1od7wp4Syi9uJu4g3TOhZj8A	false	sufficient binding region:?-?|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02241	uniprotkb:Q9NR09	intact:EBI-306852|uniprotkb:Q8WVP0|ensembl:ENSP00000260363|ensembl:ENSP00000497065|intact:EBI-2558308|uniprotkb:B4E1K0	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:kif23_human(display_long)|uniprotkb:KIF23(gene name)|psi-mi:KIF23(display_short)|uniprotkb:KNSL5(gene name synonym)|uniprotkb:MKLP1(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 1(gene name synonym)|uniprotkb:Kinesin-like protein 5(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765858|imex:IM-11898-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004847.2|refseq:NP_612565.1|ensembl:ENSG00000137807(gene)|ensembl:ENST00000260363(transcript)|ensembl:ENST00000647715(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000281"(mitotic cytokinesis)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR038105|mint:Q02241|rcsb pdb:3VHX|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|interpro:IPR032384|reactome:R-HSA-983189|ensembl:ENSP00000260363|ensembl:ENST00000352331|ensembl:ENSP00000304978|ensembl:ENSP00000497065|dip:DIP-40359N	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1|figure legend:Fig. 2J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:akVjKfOv4g4nEsGN8E3lQ2vCseQ9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:D40EE2B35966D6AA|rigid:sxQ1od7wp4Syi9uJu4g3TOhZj8A	false	-	sufficient binding region:?-?|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80U87	uniprotkb:Q02241	intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841	intact:EBI-306852|uniprotkb:Q8WVP0|ensembl:ENSP00000260363|ensembl:ENSP00000497065|intact:EBI-2558308|uniprotkb:B4E1K0	psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:kif23_human(display_long)|uniprotkb:KIF23(gene name)|psi-mi:KIF23(display_short)|uniprotkb:KNSL5(gene name synonym)|uniprotkb:MKLP1(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 1(gene name synonym)|uniprotkb:Kinesin-like protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765930|imex:IM-11898-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)	refseq:NP_004847.2|refseq:NP_612565.1|ensembl:ENSG00000137807(gene)|ensembl:ENST00000260363(transcript)|ensembl:ENST00000647715(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000281"(mitotic cytokinesis)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR038105|mint:Q02241|rcsb pdb:3VHX|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|interpro:IPR032384|reactome:R-HSA-983189|ensembl:ENSP00000260363|ensembl:ENST00000352331|ensembl:ENSP00000304978|ensembl:ENSP00000497065|dip:DIP-40359N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1; Q80U87 UBPY|figure legend:Fig. 5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090	rogid:akVjKfOv4g4nEsGN8E3lQ2vCseQ9606	intact-crc:5706017A43CD2304|rigid:5jkfryEbx+3WN9VjDFbgU0iaZeY	false	mutation:748-748|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80U87	uniprotkb:Q9NR09	intact:EBI-1765959|uniprotkb:Q80YP2|uniprotkb:Q8R0D3|uniprotkb:Q9EQU1|uniprotkb:Q9WVP5|uniprotkb:A2AI53|ensembl:ENSMUSP00000028841	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:ubp8_mouse(display_long)|uniprotkb:Usp8(gene name)|psi-mi:Usp8(display_short)|uniprotkb:Kiaa0055(gene name synonym)|uniprotkb:Ubpy(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765930|imex:IM-11898-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062703.2|ensembl:ENSMUST00000028841(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:Q80U87|rcsb pdb:1UJ0|reactome:R-MMU-1358803|reactome:R-MMU-4641263|reactome:R-MMU-5689880|reactome:R-MMU-6807004|ensembl:ENSMUSG00000027363(gene)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1; Q80U87 UBPY|figure legend:Fig. 5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:PhHue+cov/Z/PGJqR8RtRQF6qco10090	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:5706017A43CD2304|rigid:5jkfryEbx+3WN9VjDFbgU0iaZeY	false	mutation:748-748|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P53350	uniprotkb:Q9NR09	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765426|imex:IM-11898-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Supp 3D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:2671A6FC6650A50D|rigid:SdjIM//mslKvMXG6e3B9iq1jUVg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:P53350	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765434|imex:IM-11898-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE;|figure legend:Supp 3F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	intact-crc:C8B9123D7A5F794C|rigid:SdjIM//mslKvMXG6e3B9iq1jUVg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:Q02750	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-492564|ensembl:ENSP00000302486	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765440|imex:IM-11898-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02750 MAP2K1|figure legend:Supp 3G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	intact-crc:4705B1070BD3B99A|rigid:DZ+dylmYzWpnZdv4ISP2QZSnNNY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02750	uniprotkb:Q9NR09	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765446|imex:IM-11898-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02750 MAP2K1|figure legend:Supp 3E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:D2704F67102F3601|rigid:DZ+dylmYzWpnZdv4ISP2QZSnNNY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:Q96A65	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765716|imex:IM-11898-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q96A65 SEC8|figure legend:Fig. Supp 4B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	intact-crc:E39F44E291A820C6|rigid:QDUcoddOL1H9bV15Pxjp/uQHdDE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NR09	uniprotkb:Q02241	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	intact:EBI-306852|uniprotkb:Q8WVP0|ensembl:ENSP00000260363|ensembl:ENSP00000497065|intact:EBI-2558308|uniprotkb:B4E1K0	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:kif23_human(display_long)|uniprotkb:KIF23(gene name)|psi-mi:KIF23(display_short)|uniprotkb:KNSL5(gene name synonym)|uniprotkb:MKLP1(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 1(gene name synonym)|uniprotkb:Kinesin-like protein 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pohl et al. (2008)	imex:IM-11898|pubmed:18329369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1765794|imex:IM-11898-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	refseq:NP_004847.2|refseq:NP_612565.1|ensembl:ENSG00000137807(gene)|ensembl:ENST00000260363(transcript)|ensembl:ENST00000647715(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005925"(focal adhesion)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|go:"GO:0000281"(mitotic cytokinesis)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR038105|mint:Q02241|rcsb pdb:3VHX|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|interpro:IPR032384|reactome:R-HSA-983189|ensembl:ENSP00000260363|ensembl:ENST00000352331|ensembl:ENSP00000304978|ensembl:ENSP00000497065|dip:DIP-40359N	psi-mi:"MI:0469"(intact)	-	-	author-identifiers:Q9NR09 BRUCE; Q02241 MKLP1|figure legend:Fig. 2J, 4A|comment:Interaction with endogenous full length BIRC6 protein competed  out by increasing concentrations of exogenously expressed C-terminal BIRC6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/04/14	2014/10/16	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	rogid:akVjKfOv4g4nEsGN8E3lQ2vCseQ9606	intact-crc:089A59B96D836564|rigid:sxQ1od7wp4Syi9uJu4g3TOhZj8A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)