#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1202096|imex:IM-19279-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:D4C17C5A0DDF2E20|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	sufficient binding region:3366-3726(IPR001214)	sufficient binding region:3349-3726	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03164	uniprotkb:Q03164	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1202065|imex:IM-19279-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	-	-	-	figure legend:1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:811A9C93DB232F44|rigid:9veXeIMwjl4tBOo9z7Lk/oHZeRI	false	sufficient binding region:3745-3969(IPR001214)|35s radiolabel:?-?	sufficient binding region:3745-3969(IPR001214)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203248|imex:IM-19279-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:E7CD3DA24D02C6C3|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	35s radiolabel:?-?|sufficient binding region:3348-3726(IPR001214)	glutathione s tranferase tag:?-?|sufficient binding region:3348-3726(IPR001214)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VW15	uniprotkb:Q9VW15	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203285|imex:IM-19279-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	intact-crc:6BC70B22DE77F451|rigid:sXBj0iDBRFGtQZp4JzwRsXsn30U	false	sufficient binding region:1245-1525(IPR001214)|35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1245-1525(IPR001214)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03164	uniprotkb:Q03164	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203332|imex:IM-19279-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:986B3733D87E4166|rigid:9veXeIMwjl4tBOo9z7Lk/oHZeRI	false	35s radiolabel:?-?|sufficient binding region:3745-3969	sufficient binding region:3745-3969|t7 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203348|imex:IM-19279-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:DF76F496CCCBD880|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	sufficient binding region:3348-3726|35s radiolabel:?-?	t7 tag:?-?|sufficient binding region:3348-3726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VW15	uniprotkb:Q9VW15	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203364|imex:IM-19279-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/02/13	2014/10/16	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	intact-crc:B15D715A3ECE8BD5|rigid:sXBj0iDBRFGtQZp4JzwRsXsn30U	false	sufficient binding region:1245-1525(IPR001214)|35s radiolabel:?-?	sufficient binding region:1245-1525(IPR001214)|t7 tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03164	uniprotkb:Q03164	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203386|imex:IM-19279-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2007/02/13	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:D8286C7375D5122D|rigid:9veXeIMwjl4tBOo9z7Lk/oHZeRI	false	t7 tag:?-?|sufficient binding region:3745-3969	ha tag:?-?|sufficient binding region:3745-3969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203400|imex:IM-19279-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:48DCCE4361370A04|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	sufficient binding region:3348-3726|t7 tag:?-?	sufficient binding region:3348-3726|ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VW15	uniprotkb:Q9VW15	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	intact:EBI-124480|uniprotkb:Q24189|uniprotkb:Q8MQX5|ensemblmetazoa:FBpp0297151|ensemblmetazoa:FBpp0297152|intact:EBI-3414333|uniprotkb:A8WHI9|uniprotkb:M9NFL0	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:ash1_drome(display_long)|uniprotkb:ash1(gene name)|psi-mi:ash1(display_short)|uniprotkb:CG8887(orf name)|uniprotkb:KMT2H(gene name synonym)|uniprotkb:Absent small and homeotic disks protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2H(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203414|imex:IM-19279-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	flybase:FBgn0005386|refseq:NP_001246834.1|refseq:NP_524160.2|ensemblmetazoa:FBgn0005386(gene)|ensemblmetazoa:FBtr0306009(transcript)|ensemblmetazoa:FBtr0306010(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0018991"(oviposition)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048096"|go:"GO:0048477"(oogenesis)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR036427|interpro:IPR043151|interpro:IPR043319|interpro:IPR043320|dip:DIP-23637N	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2007/02/13	2014/10/16	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	rogid:E2mb98G4IutJE+mtX5O7Y22odt07227	intact-crc:6559BF8058C45E83|rigid:sXBj0iDBRFGtQZp4JzwRsXsn30U	false	sufficient binding region:1245-1525(IPR001214)|t7 tag:?-?	sufficient binding region:1245-1525(IPR001214)|ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203434|imex:IM-19279-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:F136366508014ECC|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	-	sufficient binding region:3348-3726|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20659	uniprotkb:P20659	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	intact:EBI-591327|ensemblmetazoa:FBpp0082406|ensemblmetazoa:FBpp0082409|uniprotkb:Q27255|uniprotkb:Q27327|uniprotkb:Q8INF9|uniprotkb:Q960R2|uniprotkb:Q9VFL1|uniprotkb:A4V2V9|uniprotkb:A4V2W0|intact:EBI-3404288|intact:EBI-3417031|intact:EBI-9922180|intact:EBI-9933604	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:trx_drome(display_long)|uniprotkb:KMT2A(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2A(gene name synonym)|uniprotkb:trx(gene name)|psi-mi:trx(display_short)|uniprotkb:CG8651(orf name)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1203452|imex:IM-19279-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	ensemblmetazoa:FBgn0003862(gene)|ensemblmetazoa:FBtr0082947(transcript)|ensemblmetazoa:FBtr0082950(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005704"(polytene chromosome band)|go:"GO:0007482"(haltere development)|go:"GO:0007507"(heart development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044665"(MLL1/2 complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR001214(SET)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|reactome:R-DME-8936459|reactome:R-DME-8939236|refseq:NP_001014621.1|refseq:NP_476769.1|refseq:NP_476770.1|refseq:NP_599108.1|refseq:NP_599109.1|flybase:FBgn0003862	-	-	-	figure legend:5A|caution:The authors have not specified the ranges of the SET domains used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	rogid:LDT4/pLaHAuL/kuZMReRH9ZDrNk7227	intact-crc:80B71DFADF9B43C2|rigid:IKxU8HUXg+jP4e6O2Y3jF5SAi08	false	sufficient binding region:3588..3588-3704..3704(IPR001214)	mutation decreasing interaction strength:3630-3630|mutation disrupting interaction strength:3670-3671|mutation disrupting interaction strength:3693-3693|mutation decreasing interaction strength:3697-3698|mutation decreasing interaction strength:3702-3703|mutation disrupting interaction strength:3599-3599,3601-3601|sufficient binding region:3588..3588-3704..3704(IPR001214)|mutation disrupting interaction strength:3616-3617|mutation decreasing interaction strength:3652-3653|mutation decreasing interaction strength:3662-3663|mutation decreasing interaction strength:3721-3722	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H204	uniprotkb:P06239	intact:EBI-514199|uniprotkb:Q9BZJ5|ensembl:ENSP00000237380	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:med28_human(display_long)|uniprotkb:Mediator complex subunit 28(gene name synonym)|uniprotkb:Tumor angiogenesis marker EG-1(gene name synonym)|uniprotkb:Endothelial-derived protein 1(gene name synonym)|uniprotkb:Merlin and Grb2-interacting cytoskeletal protein(gene name synonym)|uniprotkb:MED28(gene name)|psi-mi:MED28(display_short)|uniprotkb:EG1(gene name synonym)|uniprotkb:FKSG20(orf name)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rozovskaia et al. (2000)	pubmed:10656681|imex:IM-19279	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1206888|imex:IM-19279-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079481.2|ensembl:ENSG00000118579(gene)|ensembl:ENST00000237380(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|interpro:IPR021640|mint:Q9H204|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	-	-	-	figure legend:4B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/02/13	2014/10/16	rogid:1gt/0vP7vWJ+M1fU+qZPcWGj34U9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:A51969745CD00E94|rigid:+6V2m8jvE0RFwT7AqtaPUl5jl7A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)