#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P31994 uniprotkb:Q92835 intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497 intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191 psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym) psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8632408|mint:MINT-74920 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933|mint:MINT-1523739(identity) refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526|mint:MINT-1523734(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/19 2014/10/16 rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606 rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606 intact-crc:F6188FF140871549|rigid:JaXNQNquz1NXD7/JWykXBw7Ppic false tag:?-?(MINT-1523744)|phosphorylated residue:292-292(MINT-1523742)|binding-associated region:284-297(MINT-1523740) - 1 1 psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0113"(western blot) uniprotkb:P31994 uniprotkb:P29350 intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497 intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67 psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym) psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8632386|mint:MINT-74919 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933|mint:MINT-1523632(identity) ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-1523627(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/19 2014/10/16 rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606 rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606 intact-crc:AA7E70231690B667|rigid:Foj+ZS36tLckGpwmYgmH1q/tkww false phosphorylated residue:292-292(MINT-1523635)|tag:?-?(MINT-1523637)|binding-associated region:284-297(MINT-1523633) - 1 1 psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0113"(western blot) uniprotkb:P43628 uniprotkb:P29350 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8632430|mint:MINT-74921 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2|mint:MINT-1523701(identity) ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-1523696(identity) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/19 2014/10/16 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606 intact-crc:69A78124F34E875D|rigid:/fjALg7ovK9PWw+K3ScOWsHLU8U false binding-associated region:295-308(MINT-1523702)|phosphorylated residue:303-303(MINT-1523704)|tag:?-?(MINT-1523706) - 1 1 psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0113"(western blot) uniprotkb:P43628 uniprotkb:P29350 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8632493|mint:MINT-74922 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2|mint:MINT-1523720(identity) ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-1523715(identity) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/19 2014/10/16 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606 intact-crc:471E09400A1EBF4D|rigid:/fjALg7ovK9PWw+K3ScOWsHLU8U false phosphorylated residue:333-333(MINT-1523723)|tag:?-?(MINT-1523725)|binding-associated region:295-339(MINT-1523721) - 1 1 psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0113"(western blot) uniprotkb:P43628 uniprotkb:P29350 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8632515|mint:MINT-74923 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2|mint:MINT-1523763(identity) ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N|mint:MINT-1523753(identity) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/01/19 2014/10/16 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606 intact-crc:E33F39730F9E672E|rigid:/fjALg7ovK9PWw+K3ScOWsHLU8U false tag:?-?(MINT-1523768)|phosphorylated residue:303-303(MINT-1523766)|binding-associated region:295-308(MINT-1523764) binding-associated region:110-194(MINT-1523754)|glutathione s tranferase tag:?-?(MINT-1523757) 1 1 psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43628 uniprotkb:P29351 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-2620699|uniprotkb:Q9QVA8|uniprotkb:Q9R0V6|uniprotkb:O35128|uniprotkb:Q63872|uniprotkb:Q63873|uniprotkb:Q63874|uniprotkb:Q921G3|uniprotkb:Q9QVA6|uniprotkb:Q9QVA7|ensembl:ENSMUSP00000108103 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:ptn6_mouse(display_long)|uniprotkb:Ptpn6(gene name)|psi-mi:Ptpn6(display_short)|uniprotkb:Hcp(gene name synonym)|uniprotkb:Hcph(gene name synonym)|uniprotkb:Ptp1C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:70Z-SHP(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:PTPTY-42(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Burshtyn et al. (1997) mint:MINT-5221482|pubmed:9148918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8632557|mint:MINT-8027462 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2|mint:MINT-8027466(identity)|uniprotkb:P43628(original identifier) refseq:NP_001071173.1|refseq:NP_038573.2|ensembl:ENSMUSG00000004266(gene)|ensembl:ENSMUST00000112484(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29351|reactome:R-MMU-114604|reactome:R-MMU-1433559|reactome:R-MMU-210990|reactome:R-MMU-388841|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5690714|reactome:R-MMU-6798695|reactome:R-MMU-877300|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-983695|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|dip:DIP-41455N|mint:MINT-8027463(identity)|uniprotkb:P29351(original identifier) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" - comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2006/01/19 2014/10/16 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:7dtH2jT68TwvCkZu9rqVowIrEK010090 intact-crc:B7F3AFFDB4B64EDE|rigid:pKrM6hzUgICFIPwlXdqTHJvm2zo false phosphorylated residue:303-303(MINT-8027471)|binding-associated region:296-309(MINT-8027469) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)