#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32361	uniprotkb:Q05924	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	intact:EBI-3669144|uniprotkb:D6VYZ8|ensemblfungi:YLR361C	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:dcr2_yeast(display_long)|uniprotkb:DCR2(gene name)|psi-mi:DCR2(display_short)|uniprotkb:Dosage-dependent cell cycle regulator 2(gene name synonym)|uniprotkb:YLR361C(locus name)	psi-mi:"MI:0415"(enzymatic study)	Guo et al. (2006)	pubmed:16990850|imex:IM-10958|mint:MINT-5219135	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992194|mint:MINT-3380923|imex:IM-10958-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N|mint:MINT-3380924(identity)	mint:Q05924|refseq:NP_013465.1|sgd:S000004353|interpro:IPR004843(Metallophosphoesterase)|ensemblfungi:YLR361C(gene)|ensemblfungi:YLR361C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|interpro:IPR029052|mint:MINT-3380938(identity)	-	crc64:BD65D74E74365945|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/08	2014/10/16	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rogid:1KOujFZ23aLnQ4kZ4w007BTP5Ls559292	intact-crc:0ED123F2A3F39807|rigid:8ydSu6WzZLqEgZ81IxLjWVH7mYs	false	calmodulin binding peptide plus protein a tag:?-?(MINT-3380936)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05924	uniprotkb:P32361	intact:EBI-3669144|uniprotkb:D6VYZ8|ensemblfungi:YLR361C	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:dcr2_yeast(display_long)|uniprotkb:DCR2(gene name)|psi-mi:DCR2(display_short)|uniprotkb:Dosage-dependent cell cycle regulator 2(gene name synonym)|uniprotkb:YLR361C(locus name)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guo et al. (2006)	pubmed:16990850|imex:IM-10958|mint:MINT-5219135	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992257|mint:MINT-3380876|imex:IM-10958-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q05924|refseq:NP_013465.1|sgd:S000004353|interpro:IPR004843(Metallophosphoesterase)|ensemblfungi:YLR361C(gene)|ensemblfungi:YLR361C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|interpro:IPR029052|mint:MINT-3380877(identity)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N|mint:MINT-3380908(identity)	-	comment:"Stoichiometry: 1.0"	crc64:BD65D74E74365945|comment:"Stoichiometry: 1.0"	figure legend:F3B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/11/08	2014/10/16	rogid:1KOujFZ23aLnQ4kZ4w007BTP5Ls559292	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	intact-crc:6FCE21AFE0C40B25|rigid:8ydSu6WzZLqEgZ81IxLjWVH7mYs	false	his tag:c-c(MINT-3380884)	mutation increasing interaction:841-841(MINT-3380916)|mutation increasing interaction:840-840(MINT-3380919)|calmodulin binding peptide plus protein a tag:?-?(MINT-3380909)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)