#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06701	uniprotkb:P11978	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995554|imex:IM-14477-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:9C698765964F094E	figure legend:2|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:2B868419B1AD9CA0|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	fusion protein:?-?|sufficient binding region:465-782	glutathione s tranferase tag:?-?|sufficient binding region:1198-1358|mutation decreasing interaction:1307-1307	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P11978	uniprotkb:P06701	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995736|imex:IM-14477-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	psi-mi:"MI:0469"(intact)	crc64:9C698765964F094E	crc64:CA2503D7645397AC	figure legend:3|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	intact-crc:4DAD6E636D3C8EB8|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	sufficient binding region:1198-1358|glutathione s tranferase tag:?-?	fusion protein:?-?|sufficient binding region:465-782|necessary binding region:465-523	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06701	uniprotkb:P11978	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995998|imex:IM-14477-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:9C698765964F094E	figure legend:6A|comment:Sir3 464-978 has the Sir4 interaction as well as Sir3 dimerisation domain.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:D71C670911819A80|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	sufficient binding region:?-?|fusion protein:?-?	sufficient binding region:1198-1358|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06701	uniprotkb:P06701	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995838|imex:IM-14477-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:CA2503D7645397AC	figure legend:4A|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	intact-crc:CD48007E304F4064|rigid:OPrvSW2dZV0stZd4RQ1R8BIzDLg	false	sufficient binding region:?-?|his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:465-729	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06701	uniprotkb:P06701	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995862|imex:IM-14477-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:CA2503D7645397AC	figure legend:4A|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	intact-crc:1263B3AA1B70EDEE|rigid:OPrvSW2dZV0stZd4RQ1R8BIzDLg	false	tag:?-?|sufficient binding region:465-729	his tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06701	uniprotkb:P11978	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995936|imex:IM-14477-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:9C698765964F094E	figure legend:5 and table1|comment:The cooperative binding of Sir3-Sir4 was observed.  An antiparallel association of the Sir3 dimers was also observed suggestive of a self-assembly process capable of generating higher order protein complexes|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:2F59DBD4B5C29FA0|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	sufficient binding region:465-729|necessary binding region:465-573	tag:?-?|sufficient binding region:1198-1358	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06701	uniprotkb:P11978	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-995985|imex:IM-14477-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	psi-mi:"MI:0469"(intact)	crc64:CA2503D7645397AC	crc64:9C698765964F094E	figure legend:5, 6B and table 1|comment:The cooperative binding of Sir3-Sir4 was observed.  An antiparallel association of the Sir3 dimers was also observed suggestive of a self-assembly process capable of generating higher order protein complexes|comment:"In this assay the dimers of Sir3 interact with Sir4 construct and the concentration of Sir4 required to rech saturation was high. Sir4 binding activity being limited to the Sir3-(464�978) dimers constituting one-fourth of the total dimers in this mixture of subunits."|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:C5EAC8C2EAC359C5|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	sufficient binding region:?-?	tag:?-?|sufficient binding region:1198-1358	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11978	uniprotkb:P11978	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-996020|imex:IM-14477-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	psi-mi:"MI:0469"(intact)	crc64:9C698765964F094E	crc64:9C698765964F094E	figure legend:7|comment:Higher oligomers found.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:FBFC65DA5AFB2163|rigid:LXGzYY0ZG1A5jcapkLHGW4myEw4	false	sufficient binding region:1198-1358	sufficient binding region:1198-1358	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11978	uniprotkb:P06701	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	King et al. (2006)	imex:IM-14477|pubmed:16717101	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-996033|imex:IM-14477-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	psi-mi:"MI:0469"(intact)	crc64:9C698765964F094E	crc64:CA2503D7645397AC	figure legend:7|comment:Higher oligomers found.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/19	2014/10/16	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	intact-crc:F88BFBE69EB30713|rigid:h/CdwXzqJ8CLLVNsn0AD+6jdm2k	false	sufficient binding region:1198-1358	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)