#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08815	uniprotkb:O08815	intact:EBI-986112	intact:EBI-986112	psi-mi:slk_rat(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Slk(gene name)|psi-mi:Slk(display_short)|uniprotkb:Sk2(gene name synonym)	psi-mi:slk_rat(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Slk(gene name)|psi-mi:Slk(display_short)|uniprotkb:Sk2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2006)	imex:IM-14499|pubmed:16316999	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-986124|imex:IM-14499-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3780|refseq:NP_062222.2|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022165|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	rgd:3780|refseq:NP_062222.2|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022165|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	psi-mi:"MI:0469"(intact)	-	-	figure legend:2A|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	rogid:W3aH4p6i6hSPXxOSnWV3R6Hfnk810116	rogid:W3aH4p6i6hSPXxOSnWV3R6Hfnk810116	intact-crc:B65B8727843FB713|rigid:2hTI5mIF26XrlaK/yX5wvGnU6Zk	false	glutathione s tranferase tag:?-?|sufficient binding region:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O08815	-	intact:EBI-986112	-	psi-mi:slk_rat(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Slk(gene name)|psi-mi:Slk(display_short)|uniprotkb:Sk2(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Hao et al. (2006)	imex:IM-14499|pubmed:16316999	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-986183|imex:IM-14499-3	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	rgd:3780|refseq:NP_062222.2|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022165|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	comment:Interaction was carried out in the presence of gamma p32 ATP.|expression level:O08815 overexpressed|figure legend:4|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	rogid:W3aH4p6i6hSPXxOSnWV3R6Hfnk810116	-	intact-crc:7BFB378ED7FDD4C6	false	ha tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:O08815	uniprotkb:Q99683	intact:EBI-986112	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	psi-mi:slk_rat(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Slk(gene name)|psi-mi:Slk(display_short)|uniprotkb:Sk2(gene name synonym)	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Hao et al. (2006)	imex:IM-14499|pubmed:16316999	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017333|imex:IM-14499-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3780|refseq:NP_062222.2|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022165|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:4|comment:Interaction was carried out in the presence of gamma p32 ATP. Cotransfection of SLK with ASK1 resulted in marked phosphorylation of ASK1 but not SLK|expression level:O08815,  Q99683 overexpressed|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	rogid:W3aH4p6i6hSPXxOSnWV3R6Hfnk810116	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	intact-crc:3AB97B22B4625668|rigid:Gsu1Y950OVSxXQznhQ/u039MtNA	false	ha tag:?-?|sufficient binding region:1-373	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99683	-	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	-	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Hao et al. (2006)	imex:IM-14499|pubmed:16316999	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017347|imex:IM-14499-4	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:4|comment:Interaction was carried out in the presence of gamma p32 ATP.|expression level:Q99683 overexpressed|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/08/08	2014/10/16	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	-	intact-crc:EE9A556CB2CB28C7	false	ha tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-