#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60894	uniprotkb:Q16602	intact:EBI-962893|ensembl:ENSP00000254661|uniprotkb:Q6FGS5	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	psi-mi:ramp1_human(display_long)|uniprotkb:RAMP1(gene name)|psi-mi:RAMP1(display_short)|uniprotkb:Calcitonin-receptor-like receptor activity-modifying protein 1(gene name synonym)	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Conner et al. (2006)	imex:IM-14540|pubmed:16293613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962890|imex:IM-14540-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132329(gene)|ensembl:ENST00000254661(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0015026"(coreceptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0005886"(plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0043235"(receptor complex)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0097643"(amylin receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:0150056"(amylin receptor complex 1)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990407"(calcitonin gene-related peptide binding)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|interpro:IPR006985(Receptor activity modifying protein)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR038126|rcsb pdb:2YX8|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6ZHO|go:"GO:0009986"(cell surface)|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_005846.1|dip:DIP-37675N	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm)	-	-	caution:Species origin of RAMP1 clone assumed from previous work by this group.|figure legend:3b|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/07/06	2014/10/16	rogid:AjPlwP60HYwVhzaZc86mkP6XjYQ9606	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	intact-crc:D378E612458045D3|rigid:AgCEvgVj/m2+VoE6l8B0KBgDplU	false	-	ha tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06881-PRO_0000004054	uniprotkb:Q16602	intact:EBI-962972	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	psi-mi:p06881-pro_0000004054(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Conner et al. (2006)	imex:IM-14540|pubmed:16293613	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-962963|imex:IM-14540-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	intact:EBI-962928(chain-parent)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	go:"GO:0005102"(signaling receptor binding)	chain-seq-start:83|chain-seq-end:119	-	comment:Addtional detail on alphaCGRP peptide taken from vendors catalogue|figure legend:Table 3, Fig. 4|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/06	2014/10/16	rogid:I325+5UFSlBI9a/kg2RBtHheFwM9606	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	intact-crc:39B338445EF31B06|rigid:T7VidMuH3ADiqiyGiFf7gwDXJFY	false	-	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)