#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P07151 uniprotkb:P13599 intact:EBI-1031212|ensembl:ENSRNOP00000023017 intact:EBI-1031194|ensembl:ENSRNOP00000027944 psi-mi:b2mg_rat(display_long)|uniprotkb:B2m(gene name)|psi-mi:B2m(display_short) psi-mi:fcgrn_rat(display_long)|uniprotkb:Fcgrt(gene name)|psi-mi:Fcgrt(display_short)|uniprotkb:Fcrn(gene name synonym)|uniprotkb:Neonatal Fc receptor(gene name synonym)|uniprotkb:IgG Fc fragment receptor transporter alpha chain(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Martin et al. (2001) pubmed:11336709 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1031225|rcsb pdb:1I1A - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036644.1|rgd:2189|ensembl:ENSRNOG00000017123(gene)|ensembl:ENSRNOT00000023017(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007611"(learning or memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0042026"(protein refolding)|go:"GO:0042493"|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071283"("cellular response to iron(III) ion")|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1904434"(positive regulation of ferrous iron binding)|go:"GO:1904437"(positive regulation of transferrin receptor binding)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2000978"(negative regulation of forebrain neuron differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015707(Beta-2-Microglobulin)|interpro:IPR036179|rcsb pdb:1ED3|rcsb pdb:1FRT|rcsb pdb:1I1A|rcsb pdb:1KJM|rcsb pdb:1KJV|rcsb pdb:2FRT|rcsb pdb:3FRU|rcsb pdb:6NF7|reactome:R-RNO-1236974|reactome:R-RNO-1236977|reactome:R-RNO-198933|reactome:R-RNO-2172127|reactome:R-RNO-2424491|reactome:R-RNO-6798695|reactome:R-RNO-983170 refseq:XP_006229105.1|rgd:61811|refseq:NP_203502.1|ensembl:ENSRNOG00000020583(gene)|ensembl:ENSRNOT00000027944(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019770"(IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0030881"(beta-2-microglobulin binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1FRT|rcsb pdb:1I1A|rcsb pdb:2FRT|rcsb pdb:3FRU|refseq:XP_008757565.1 - - - assembly:dimeric, multimeric|3d-r-factors:working 77.800%, free 70.800%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:L1E4C8UB88GfVwa4DKn38Q090S410116 rogid:d06EPJhg8RhFDQ4jCj17ZMTQyf810116 intact-crc:9CF16A3A77BB40ED|rigid:at61H2TE0bItkv2ihuqf/atAMRo false sufficient binding region:21-119 sufficient binding region:23-291 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07151 uniprotkb:P20760 intact:EBI-1031212|ensembl:ENSRNOP00000023017 intact:EBI-1031206 psi-mi:b2mg_rat(display_long)|uniprotkb:B2m(gene name)|psi-mi:B2m(display_short) psi-mi:igg2a_rat(display_long)|uniprotkb:Igg-2a(gene name)|psi-mi:Igg-2a(display_short) psi-mi:"MI:0114"(x-ray crystallography) Martin et al. (2001) pubmed:11336709 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1031225|rcsb pdb:1I1A - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036644.1|rgd:2189|ensembl:ENSRNOG00000017123(gene)|ensembl:ENSRNOT00000023017(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002481"(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007611"(learning or memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0042026"(protein refolding)|go:"GO:0042493"|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071283"("cellular response to iron(III) ion")|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1904434"(positive regulation of ferrous iron binding)|go:"GO:1904437"(positive regulation of transferrin receptor binding)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2000978"(negative regulation of forebrain neuron differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015707(Beta-2-Microglobulin)|interpro:IPR036179|rcsb pdb:1ED3|rcsb pdb:1FRT|rcsb pdb:1I1A|rcsb pdb:1KJM|rcsb pdb:1KJV|rcsb pdb:2FRT|rcsb pdb:3FRU|rcsb pdb:6NF7|reactome:R-RNO-1236974|reactome:R-RNO-1236977|reactome:R-RNO-198933|reactome:R-RNO-2172127|reactome:R-RNO-2424491|reactome:R-RNO-6798695|reactome:R-RNO-983170 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003597(Immunoglobulin C1-set)|rgd:1359626|rcsb pdb:1FN4|rcsb pdb:1I1A|rcsb pdb:1I1C|go:"GO:0003823"(antigen binding)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4UAO|interpro:IPR036179 - - - assembly:dimeric, multimeric|3d-r-factors:working 77.800%, free 70.800%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:L1E4C8UB88GfVwa4DKn38Q090S410116 rogid:a1v/77eIoDQCvcxyiAtzQg3l0tw10116 intact-crc:9CF16A3A77BB40ED|rigid:at61H2TE0bItkv2ihuqf/atAMRo false sufficient binding region:21-119 sufficient binding region:98-322 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)